Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubul...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.475-478 |
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| container_issue | 3 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | SCHMIDT, Eric W. RAVENTOS-SUAREZ, Carmen BIFANO, Marc MENENDEZ, Ana T. FAIRCHILD, Craig R. FAULKNER, D. John |
| description | The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines. |
| doi_str_mv | 10.1021/np034035z |
| format | Article |
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John</creator><creatorcontrib>SCHMIDT, Eric W. ; RAVENTOS-SUAREZ, Carmen ; BIFANO, Marc ; MENENDEZ, Ana T. ; FAIRCHILD, Craig R. ; FAULKNER, D. John</creatorcontrib><description>The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np034035z</identifier><identifier>PMID: 15043437</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents ; Biological and medical sciences ; Brain - drug effects ; Cattle ; Cell Cycle - drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Female ; General pharmacology ; Humans ; Lithistida ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Oceans and Seas ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - isolation & purification ; Peptides, Cyclic - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Porifera - chemistry ; Scleritoderma nodosum ; Tubulin Modulators ; Tumor Cells, Cultured ; Vinblastine - pharmacology</subject><ispartof>Journal of natural products (Washington, D.C.), 2004-03, Vol.67 (3), p.475-478</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15637623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15043437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMIDT, Eric W.</creatorcontrib><creatorcontrib>RAVENTOS-SUAREZ, Carmen</creatorcontrib><creatorcontrib>BIFANO, Marc</creatorcontrib><creatorcontrib>MENENDEZ, Ana T.</creatorcontrib><creatorcontrib>FAIRCHILD, Craig R.</creatorcontrib><creatorcontrib>FAULKNER, D. John</creatorcontrib><title>Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.</description><subject>Animals</subject><subject>Antineoplastic Agents</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Cattle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Lithistida</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Oceans and Seas</subject><subject>Peptides, Cyclic - chemistry</subject><subject>Peptides, Cyclic - isolation & purification</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Porifera - chemistry</subject><subject>Scleritoderma nodosum</subject><subject>Tubulin Modulators</subject><subject>Tumor Cells, Cultured</subject><subject>Vinblastine - pharmacology</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQBuAgiq4fB_-A5KInq5OkSdqjrK4Ki667ehNK2qYabZuatLD66w3sKt48vcPMwzAMQocEzghQct52wGJg_GsDjQinEAmgfBONgAgWsUTEO2jX-zcAYJDybbRDOMQsZnKEnhdFrZ3pbaldY1p8cYoVHn_2trdLU4SqqEPMdNebUuPK2Qb3rxpPTf9qfOjhRWfbF43_rlG4taX1Q7OPtipVe32wzj30NLl6HN9E0_vr2_HFNDIMRB-pGBKW5gVowiUBUaayolVKVZzqPA9Hx1wzUYg8AVHRUueEJQCcVpQQUqmc7aGT1d7O2Y9B-z5rjC90XatW28FnkkgZfPIvJDIRhEga4NEaDnmjy6xzplHuM_t5XADHa6B8oerKqbYw_o8TTArKgotWLnxLL3_nyr1nQjLJs8fZIruczx7m08lNdse-AWeUio4</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>SCHMIDT, Eric W.</creator><creator>RAVENTOS-SUAREZ, Carmen</creator><creator>BIFANO, Marc</creator><creator>MENENDEZ, Ana T.</creator><creator>FAIRCHILD, Craig R.</creator><creator>FAULKNER, D. 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| ispartof | Journal of natural products (Washington, D.C.), 2004-03, Vol.67 (3), p.475-478 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71770528 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antineoplastic Agents Biological and medical sciences Brain - drug effects Cattle Cell Cycle - drug effects Cell Line, Tumor Drug Screening Assays, Antitumor Female General pharmacology Humans Lithistida Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oceans and Seas Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Scleritoderma nodosum Tubulin Modulators Tumor Cells, Cultured Vinblastine - pharmacology |
| title | Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum |
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