Cre recombinase-mediated gene targeting of mesenchymal cells

Loss‐of‐function approaches by the Cre/loxP technology have provided powerful tools for functional analyses of genes of interest expressed preferentially in a particular tissue. Here we describe the generation of transgenic mouse lines expressing Cre recombinase under the control of the promoter/enh...

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2004-03, Vol.38 (3), p.139-144
Hauptverfasser:	Florin, Lore, Alter, Heike, Gröne, Hermann-Josef, Szabowski, Axel, Schütz, Günther, Angel, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics Chromosomes, Artificial, P1 Bacteriophage - physiology collagen Collagen - genetics Collagen Type I collagen, cre recombinase, fibroblast, mesenchyme, PAC cre recombinase Enzyme Inhibitors - metabolism Female fibroblast Gene Expression Regulation, Developmental - genetics Gene Targeting - methods Integrases - genetics Integrases - metabolism Lac Operon Male mesenchyme Mesoderm - physiology Mice Mice, Transgenic - embryology Mice, Transgenic - genetics Mice, Transgenic - growth & development PAC Promoter Regions, Genetic - genetics Recombination, Genetic
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