Competence of the Human Host as a Reservoir for Leishmania chagasi
The failure of control programs for visceral leishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fly, laboratory-reared L...
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| Veröffentlicht in: | The Journal of infectious diseases 2000-09, Vol.182 (3), p.997-1000 |
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| container_title | The Journal of infectious diseases |
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| creator | Costa, Carlos H. N. Gomes, Régis B. B. Silva, Mauro R. B. Garcez, Lourdes M. Ramos, Patricia K. S. Santos, Regina S. Shaw, Jeffrey J. David, John R. Maguire, James H. |
| description | The failure of control programs for visceral leishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fly, laboratory-reared Lutzomyia longipalpis were allowed to feed on Brazilian subjects with active, cured, and asymptomatic VL and on asymptomatic residents of houses of persons with active VL. Of 3747 insects that had fed, 26 acquired infection from 11 of the 44 persons with active VL, but none acquired infection from the 137 asymptomatic persons. Among persons |
| doi_str_mv | 10.1086/315795 |
| format | Article |
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N. ; Gomes, Régis B. B. ; Silva, Mauro R. B. ; Garcez, Lourdes M. ; Ramos, Patricia K. S. ; Santos, Regina S. ; Shaw, Jeffrey J. ; David, John R. ; Maguire, James H.</creator><creatorcontrib>Costa, Carlos H. N. ; Gomes, Régis B. B. ; Silva, Mauro R. B. ; Garcez, Lourdes M. ; Ramos, Patricia K. S. ; Santos, Regina S. ; Shaw, Jeffrey J. ; David, John R. ; Maguire, James H.</creatorcontrib><description>The failure of control programs for visceral leishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fly, laboratory-reared Lutzomyia longipalpis were allowed to feed on Brazilian subjects with active, cured, and asymptomatic VL and on asymptomatic residents of houses of persons with active VL. Of 3747 insects that had fed, 26 acquired infection from 11 of the 44 persons with active VL, but none acquired infection from the 137 asymptomatic persons. Among persons <4 years old with active VL, a history of diarrhea and higher peripheral blood neutrophil counts were independent predictors of infectivity. Further experiments using larger numbers of insects are necessary to evaluate the reservoir competence of persons with asymptomatic infections, who represent a large segment of the population of several Brazilian cities.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315795</identifier><identifier>PMID: 10950806</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Animals ; Antibodies ; Biological and medical sciences ; Blood ; Brazil ; Child ; Child, Preschool ; Concise Communications ; Diarrhea ; Disease Reservoirs ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Human protozoal diseases ; Humans ; Infant ; Infections ; Infectious diseases ; Insect vectors ; Leishmania ; Leishmania chagasi ; Leishmaniasis, Visceral - transmission ; Leshmaniasis ; Lutzomyia longipalpis ; Medical sciences ; Neutrophils ; Parasites ; Parasitic diseases ; Polymerase Chain Reaction ; Protozoal diseases ; Psychodidae ; Tropical medicine ; Visceral leishmaniasis</subject><ispartof>The Journal of infectious diseases, 2000-09, Vol.182 (3), p.997-1000</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2001 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Sep 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-17afd679a319b7606c8dcd62df5e6ed4d0f2e1a06fea5420ff23a85557d9cfde3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30109314$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30109314$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=959586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10950806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Carlos H. N.</creatorcontrib><creatorcontrib>Gomes, Régis B. B.</creatorcontrib><creatorcontrib>Silva, Mauro R. B.</creatorcontrib><creatorcontrib>Garcez, Lourdes M.</creatorcontrib><creatorcontrib>Ramos, Patricia K. S.</creatorcontrib><creatorcontrib>Santos, Regina S.</creatorcontrib><creatorcontrib>Shaw, Jeffrey J.</creatorcontrib><creatorcontrib>David, John R.</creatorcontrib><creatorcontrib>Maguire, James H.</creatorcontrib><title>Competence of the Human Host as a Reservoir for Leishmania chagasi</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>The failure of control programs for visceral leishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fly, laboratory-reared Lutzomyia longipalpis were allowed to feed on Brazilian subjects with active, cured, and asymptomatic VL and on asymptomatic residents of houses of persons with active VL. Of 3747 insects that had fed, 26 acquired infection from 11 of the 44 persons with active VL, but none acquired infection from the 137 asymptomatic persons. Among persons <4 years old with active VL, a history of diarrhea and higher peripheral blood neutrophil counts were independent predictors of infectivity. Further experiments using larger numbers of insects are necessary to evaluate the reservoir competence of persons with asymptomatic infections, who represent a large segment of the population of several Brazilian cities.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Brazil</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Concise Communications</subject><subject>Diarrhea</subject><subject>Disease Reservoirs</subject><subject>Dogs</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Insect vectors</subject><subject>Leishmania</subject><subject>Leishmania chagasi</subject><subject>Leishmaniasis, Visceral - transmission</subject><subject>Leshmaniasis</subject><subject>Lutzomyia longipalpis</subject><subject>Medical sciences</subject><subject>Neutrophils</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Polymerase Chain Reaction</subject><subject>Protozoal diseases</subject><subject>Psychodidae</subject><subject>Tropical medicine</subject><subject>Visceral leishmaniasis</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EuLFDEUBeAgitMz6j9QggPuSvOoJJXl2D5abBBkHGU24U5yY1fbVWmTKtF_bw3VtOLG1V2cjwP3EPKIs-ecNfqF5MpYdYcsuJKm0prLu2TBmBAVb6w9IaelbBljtdTmPjnhzCrWML0gL5ep2-OAvUeaIh02SFdjBz1dpTJQKBToRyyYf6Q205gyXWNbNhNogfoNfIXSPiD3IuwKPjzcM_LpzevL5apaf3j7bnmxrnwt-FBxAzFoY0Fye2M0074JPmgRokKNoQ4sCuTAdERQtWAxCgmNUsoE62NAeUaezb37nL6PWAbXtcXjbgc9prE4w422gtn_Qt5M79eNnODTf-A2jbmfnnBCSMsZV_xPm8-plIzR7XPbQf7lOHO327t5-wk-ObSNNx2Gv9g89gTODwCKh13M0Pu2HJ1VVjW36vGstmVI-ZhKNvVIXk95NedtGfDnMYf8zWkjjXKrL9euvn519VlevXeX8jfO06FT</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Costa, Carlos H. N.</creator><creator>Gomes, Régis B. B.</creator><creator>Silva, Mauro R. B.</creator><creator>Garcez, Lourdes M.</creator><creator>Ramos, Patricia K. S.</creator><creator>Santos, Regina S.</creator><creator>Shaw, Jeffrey J.</creator><creator>David, John R.</creator><creator>Maguire, James H.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7SS</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Competence of the Human Host as a Reservoir for Leishmania chagasi</title><author>Costa, Carlos H. N. ; Gomes, Régis B. B. ; Silva, Mauro R. B. ; Garcez, Lourdes M. ; Ramos, Patricia K. S. ; Santos, Regina S. ; Shaw, Jeffrey J. ; David, John R. ; Maguire, James H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-17afd679a319b7606c8dcd62df5e6ed4d0f2e1a06fea5420ff23a85557d9cfde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Brazil</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Concise Communications</topic><topic>Diarrhea</topic><topic>Disease Reservoirs</topic><topic>Dogs</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Insect vectors</topic><topic>Leishmania</topic><topic>Leishmania chagasi</topic><topic>Leishmaniasis, Visceral - transmission</topic><topic>Leshmaniasis</topic><topic>Lutzomyia longipalpis</topic><topic>Medical sciences</topic><topic>Neutrophils</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Polymerase Chain Reaction</topic><topic>Protozoal diseases</topic><topic>Psychodidae</topic><topic>Tropical medicine</topic><topic>Visceral leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Carlos H. 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N.</au><au>Gomes, Régis B. B.</au><au>Silva, Mauro R. B.</au><au>Garcez, Lourdes M.</au><au>Ramos, Patricia K. S.</au><au>Santos, Regina S.</au><au>Shaw, Jeffrey J.</au><au>David, John R.</au><au>Maguire, James H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Competence of the Human Host as a Reservoir for Leishmania chagasi</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>182</volume><issue>3</issue><spage>997</spage><epage>1000</epage><pages>997-1000</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The failure of control programs for visceral leishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fly, laboratory-reared Lutzomyia longipalpis were allowed to feed on Brazilian subjects with active, cured, and asymptomatic VL and on asymptomatic residents of houses of persons with active VL. Of 3747 insects that had fed, 26 acquired infection from 11 of the 44 persons with active VL, but none acquired infection from the 137 asymptomatic persons. Among persons <4 years old with active VL, a history of diarrhea and higher peripheral blood neutrophil counts were independent predictors of infectivity. Further experiments using larger numbers of insects are necessary to evaluate the reservoir competence of persons with asymptomatic infections, who represent a large segment of the population of several Brazilian cities.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10950806</pmid><doi>10.1086/315795</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2000-09, Vol.182 (3), p.997-1000 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Animals Antibodies Biological and medical sciences Blood Brazil Child Child, Preschool Concise Communications Diarrhea Disease Reservoirs Dogs Enzyme-Linked Immunosorbent Assay Human protozoal diseases Humans Infant Infections Infectious diseases Insect vectors Leishmania Leishmania chagasi Leishmaniasis, Visceral - transmission Leshmaniasis Lutzomyia longipalpis Medical sciences Neutrophils Parasites Parasitic diseases Polymerase Chain Reaction Protozoal diseases Psychodidae Tropical medicine Visceral leishmaniasis |
| title | Competence of the Human Host as a Reservoir for Leishmania chagasi |
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