Neisseria meningitidis, Neisseria lactamica and Moraxella catarrhalis share cross-reactive carbohydrate antigens
Carriage of commensal bacteria species is associated with the development of natural immunity to meningococcal disease, with lipo-oligosaccharides (LOS) of meningococci being one of the main virulence factors associated with severity of meningococcal disease. Meningococcal reference strains and isol...
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| Veröffentlicht in: | Vaccine 2004-02, Vol.22 (7), p.898-908 |
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| creator | Braun, Jan M Beuth, Josef Blackwell, C.Caroline Giersen, Sonja Higgins, Paul G Tzanakaki, Georgina Unverhau, Heike Weir, Donald M |
| description | Carriage of commensal bacteria species is associated with the development of natural immunity to meningococcal disease, with lipo-oligosaccharides (LOS) of meningococci being one of the main virulence factors associated with severity of meningococcal disease. Meningococcal reference strains and isolates from the commensal species
Neisseria lactamica and
Moraxella catarrhalis were assessed for the presence of cross-reactive glycoconjugate antigens. Binding of human blood group antibodies of the P and Ii system to meningococcal immunotype reference strains were in accordance with the presence of known LOS carbohydrate structures. Binding studies with meningococcal immunotyping antibodies and blood group phenotyping antibodies to
N. lactamica strains from different European countries showed, that a greater number of isolates obtained from native Greek and Scottish adults and children bound anti-meningococcal L(3, 7, 9) immunotyping (
P |
| doi_str_mv | 10.1016/j.vaccine.2003.11.036 |
| format | Article |
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Neisseria lactamica and
Moraxella catarrhalis were assessed for the presence of cross-reactive glycoconjugate antigens. Binding of human blood group antibodies of the P and Ii system to meningococcal immunotype reference strains were in accordance with the presence of known LOS carbohydrate structures. Binding studies with meningococcal immunotyping antibodies and blood group phenotyping antibodies to
N. lactamica strains from different European countries showed, that a greater number of isolates obtained from native Greek and Scottish adults and children bound anti-meningococcal L(3, 7, 9) immunotyping (
P<0.001), p
K (
P=0.035) and paragloboside (
P<0.001) blood group typing antibodies compared to isolates obtained from children of Russian immigrants in Greece. A greater number of
M. catarrhalis strains isolated from children in Scotland bound anti-L(3, 7, 9) antibodies (38.2%) compared to strains isolated from adults (22.2%) (
P=0.017). These findings provide evidence that blood group like glycoconjugate antigens found on the commensal species
N. lactamica and
M. catarrhalis might be involved in the development of natural immunity to meningococcal endotoxins during childhood, and might be exploited as anti-meningococcal vaccine candidates.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2003.11.036</identifier><identifier>PMID: 15040943</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Age Factors ; Antibodies - analysis ; Antibodies, Bacterial - analysis ; Antibody Specificity ; Antigens, Bacterial - immunology ; Applied microbiology ; Bacteriology ; Biological and medical sciences ; Blood Group Antigens - immunology ; Carbohydrates - immunology ; Child ; Cross Reactions ; Cross-reactivity ; Endotoxin ; Enzyme-Linked Immunosorbent Assay ; Europe ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Lipopolysaccharides - immunology ; Male ; Meningococcal disease ; Microbiology ; Miscellaneous ; Moraxella (Branhamella) catarrhalis - growth & development ; Moraxella (Branhamella) catarrhalis - immunology ; Moraxella catarrhalis ; Neisseria lactamica ; Neisseria lactamica - growth & development ; Neisseria lactamica - immunology ; Neisseria meningitidis ; Neisseria meningitidis - growth & development ; Neisseria meningitidis - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2004-02, Vol.22 (7), p.898-908</ispartof><rights>2003 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-2c43285ef080f0251ffccc5826c41f55e0f81039ab2090f0893e284ada67f88a3</citedby><cites>FETCH-LOGICAL-c422t-2c43285ef080f0251ffccc5826c41f55e0f81039ab2090f0893e284ada67f88a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vaccine.2003.11.036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976,64366</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15533536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15040943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braun, Jan M</creatorcontrib><creatorcontrib>Beuth, Josef</creatorcontrib><creatorcontrib>Blackwell, C.Caroline</creatorcontrib><creatorcontrib>Giersen, Sonja</creatorcontrib><creatorcontrib>Higgins, Paul G</creatorcontrib><creatorcontrib>Tzanakaki, Georgina</creatorcontrib><creatorcontrib>Unverhau, Heike</creatorcontrib><creatorcontrib>Weir, Donald M</creatorcontrib><title>Neisseria meningitidis, Neisseria lactamica and Moraxella catarrhalis share cross-reactive carbohydrate antigens</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Carriage of commensal bacteria species is associated with the development of natural immunity to meningococcal disease, with lipo-oligosaccharides (LOS) of meningococci being one of the main virulence factors associated with severity of meningococcal disease. Meningococcal reference strains and isolates from the commensal species
Neisseria lactamica and
Moraxella catarrhalis were assessed for the presence of cross-reactive glycoconjugate antigens. Binding of human blood group antibodies of the P and Ii system to meningococcal immunotype reference strains were in accordance with the presence of known LOS carbohydrate structures. Binding studies with meningococcal immunotyping antibodies and blood group phenotyping antibodies to
N. lactamica strains from different European countries showed, that a greater number of isolates obtained from native Greek and Scottish adults and children bound anti-meningococcal L(3, 7, 9) immunotyping (
P<0.001), p
K (
P=0.035) and paragloboside (
P<0.001) blood group typing antibodies compared to isolates obtained from children of Russian immigrants in Greece. A greater number of
M. catarrhalis strains isolated from children in Scotland bound anti-L(3, 7, 9) antibodies (38.2%) compared to strains isolated from adults (22.2%) (
P=0.017). These findings provide evidence that blood group like glycoconjugate antigens found on the commensal species
N. lactamica and
M. catarrhalis might be involved in the development of natural immunity to meningococcal endotoxins during childhood, and might be exploited as anti-meningococcal vaccine candidates.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Antibodies - analysis</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Antibody Specificity</subject><subject>Antigens, Bacterial - immunology</subject><subject>Applied microbiology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Blood Group Antigens - immunology</subject><subject>Carbohydrates - immunology</subject><subject>Child</subject><subject>Cross Reactions</subject><subject>Cross-reactivity</subject><subject>Endotoxin</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Europe</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lipopolysaccharides - immunology</subject><subject>Male</subject><subject>Meningococcal disease</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Moraxella (Branhamella) catarrhalis - growth & development</subject><subject>Moraxella (Branhamella) catarrhalis - immunology</subject><subject>Moraxella catarrhalis</subject><subject>Neisseria lactamica</subject><subject>Neisseria lactamica - growth & development</subject><subject>Neisseria lactamica - immunology</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - growth & development</subject><subject>Neisseria meningitidis - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYsvCTwDlAicSZuw4dU4IrfiSFriAxM2aOuOtq3wUO63Yf4-7jbTc9mTZet7xzDxCvESoELB5t6uO5FwYuZIAqkKsQDWPxArNWpVSo3ksViCbuqwRfl-IZyntAEArbJ-KC9RQQ1urldh_55ASx0DFwGMYb8IcupDeFvfvPbmZhuCooLErvk2R_nLfU-Fophi31IdUpC1FLlycUioj50A45ivFzbS97SLNnLNzuOExPRdPPPWJXyznpfj16ePPqy_l9Y_PX68-XJeulnIupauVNJo9GPCQ5_HeOaeNbFyNXmsGbxBUSxsJbSZMq1iamjpq1t4YUpfizbnuPk5_DpxmO4TkTo2PPB2SXeO6MS02D4LYSq3aFjOoz-DdmJG93ccwULy1CPbkxO7s4sSenFhEm53k3Kvlg8Nm4O4-tUjIwOsFoOSo95FGF9J_nFZK3xV6f-Y47-0YONrkAo-OuxDZzbabwgOt_APpHa57</recordid><startdate>20040217</startdate><enddate>20040217</enddate><creator>Braun, Jan M</creator><creator>Beuth, Josef</creator><creator>Blackwell, C.Caroline</creator><creator>Giersen, Sonja</creator><creator>Higgins, Paul G</creator><creator>Tzanakaki, Georgina</creator><creator>Unverhau, Heike</creator><creator>Weir, Donald M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040217</creationdate><title>Neisseria meningitidis, Neisseria lactamica and Moraxella catarrhalis share cross-reactive carbohydrate antigens</title><author>Braun, Jan M ; Beuth, Josef ; Blackwell, C.Caroline ; Giersen, Sonja ; Higgins, Paul G ; Tzanakaki, Georgina ; Unverhau, Heike ; Weir, Donald M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-2c43285ef080f0251ffccc5826c41f55e0f81039ab2090f0893e284ada67f88a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Antibodies - analysis</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Antibody Specificity</topic><topic>Antigens, Bacterial - immunology</topic><topic>Applied microbiology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Blood Group Antigens - immunology</topic><topic>Carbohydrates - immunology</topic><topic>Child</topic><topic>Cross Reactions</topic><topic>Cross-reactivity</topic><topic>Endotoxin</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Europe</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lipopolysaccharides - immunology</topic><topic>Male</topic><topic>Meningococcal disease</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Moraxella (Branhamella) catarrhalis - growth & development</topic><topic>Moraxella (Branhamella) catarrhalis - immunology</topic><topic>Moraxella catarrhalis</topic><topic>Neisseria lactamica</topic><topic>Neisseria lactamica - growth & development</topic><topic>Neisseria lactamica - immunology</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - growth & development</topic><topic>Neisseria meningitidis - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, Jan M</creatorcontrib><creatorcontrib>Beuth, Josef</creatorcontrib><creatorcontrib>Blackwell, C.Caroline</creatorcontrib><creatorcontrib>Giersen, Sonja</creatorcontrib><creatorcontrib>Higgins, Paul G</creatorcontrib><creatorcontrib>Tzanakaki, Georgina</creatorcontrib><creatorcontrib>Unverhau, Heike</creatorcontrib><creatorcontrib>Weir, Donald M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, Jan M</au><au>Beuth, Josef</au><au>Blackwell, C.Caroline</au><au>Giersen, Sonja</au><au>Higgins, Paul G</au><au>Tzanakaki, Georgina</au><au>Unverhau, Heike</au><au>Weir, Donald M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neisseria meningitidis, Neisseria lactamica and Moraxella catarrhalis share cross-reactive carbohydrate antigens</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2004-02-17</date><risdate>2004</risdate><volume>22</volume><issue>7</issue><spage>898</spage><epage>908</epage><pages>898-908</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Carriage of commensal bacteria species is associated with the development of natural immunity to meningococcal disease, with lipo-oligosaccharides (LOS) of meningococci being one of the main virulence factors associated with severity of meningococcal disease. Meningococcal reference strains and isolates from the commensal species
Neisseria lactamica and
Moraxella catarrhalis were assessed for the presence of cross-reactive glycoconjugate antigens. Binding of human blood group antibodies of the P and Ii system to meningococcal immunotype reference strains were in accordance with the presence of known LOS carbohydrate structures. Binding studies with meningococcal immunotyping antibodies and blood group phenotyping antibodies to
N. lactamica strains from different European countries showed, that a greater number of isolates obtained from native Greek and Scottish adults and children bound anti-meningococcal L(3, 7, 9) immunotyping (
P<0.001), p
K (
P=0.035) and paragloboside (
P<0.001) blood group typing antibodies compared to isolates obtained from children of Russian immigrants in Greece. A greater number of
M. catarrhalis strains isolated from children in Scotland bound anti-L(3, 7, 9) antibodies (38.2%) compared to strains isolated from adults (22.2%) (
P=0.017). These findings provide evidence that blood group like glycoconjugate antigens found on the commensal species
N. lactamica and
M. catarrhalis might be involved in the development of natural immunity to meningococcal endotoxins during childhood, and might be exploited as anti-meningococcal vaccine candidates.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15040943</pmid><doi>10.1016/j.vaccine.2003.11.036</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Vaccine, 2004-02, Vol.22 (7), p.898-908 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adolescent Age Factors Antibodies - analysis Antibodies, Bacterial - analysis Antibody Specificity Antigens, Bacterial - immunology Applied microbiology Bacteriology Biological and medical sciences Blood Group Antigens - immunology Carbohydrates - immunology Child Cross Reactions Cross-reactivity Endotoxin Enzyme-Linked Immunosorbent Assay Europe Female Fundamental and applied biological sciences. Psychology Humans Lipopolysaccharides - immunology Male Meningococcal disease Microbiology Miscellaneous Moraxella (Branhamella) catarrhalis - growth & development Moraxella (Branhamella) catarrhalis - immunology Moraxella catarrhalis Neisseria lactamica Neisseria lactamica - growth & development Neisseria lactamica - immunology Neisseria meningitidis Neisseria meningitidis - growth & development Neisseria meningitidis - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Neisseria meningitidis, Neisseria lactamica and Moraxella catarrhalis share cross-reactive carbohydrate antigens |
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