Poly(l-lysine)-modified silica nanoparticles for the delivery of antisense oligonucleotides

Silica nanoparticles were prepared in a microemulsion system, using polyoxyethylene nonylphenyl ether/cyclohexane/ammonium hydroxide. The surface charge of the particle was modified with PLL [poly(l‐lysine)]. PAGE demonstrated the ability of PMS‐NP (PLL‐modified silica nanoparticles) to bind and pro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biotechnology and applied biochemistry 2004-04, Vol.39 (2), p.179-187
Hauptverfasser:	Zhu, Shi-Guo, Xiang, Juan-Juan, Li, Xiao-Ling, Shen, Shou-Rong, Lu, Hong-bin, Zhou, Jie, Xiong, Wei, Zhang, Bi-Cheng, Nie, Xin-Min, Zhou, Ming, Tang, Ke, Li, Gui-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense delivery antisense oligonucleotides Biological and medical sciences Biotechnology Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell Line, Tumor Coated Materials, Biocompatible - chemistry Drug Carriers - chemistry Fundamental and applied biological sciences. Psychology Gene Transfer Techniques HeLa Cells Humans Materials Testing Nanotubes - chemistry Nanotubes - ultrastructure Oligoribonucleotides, Antisense - administration & dosage Oligoribonucleotides, Antisense - chemistry Oligoribonucleotides, Antisense - genetics Oligoribonucleotides, Antisense - pharmacokinetics Particle Size poly(l-lysine) Polylysine - chemistry protein interaction silica nanoparticles Silicon Dioxide - chemistry Surface Properties Tissue Distribution Transfection - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!