Presynaptic K + channels: electrifying regulators of synaptic terminal excitability
Potassium channels are crucial regulators of neuronal excitability, setting resting membrane potentials and firing thresholds, repolarizing action potentials and limiting excitability. Although most of our understanding of K + channels is based on somatic recordings, there is good evidence that thes...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2004-04, Vol.27 (4), p.210-217 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | Dodson, Paul D. Forsythe, Ian D. |
| description | Potassium channels are crucial regulators of neuronal excitability, setting resting membrane potentials and firing thresholds, repolarizing action potentials and limiting excitability. Although most of our understanding of K
+ channels is based on somatic recordings, there is good evidence that these channels are present in synaptic terminals. In recent years the improved access to presynaptic compartments afforded by direct recording techniques has indicated diverse roles for native K
+ channels, from suppression of aberrant firing to action potential repolarization and activity-dependent modulation of synaptic activity. This article reviews the growing evidence for multiple roles and discrete localization of distinct K
+ channels at presynaptic terminals. |
| doi_str_mv | 10.1016/j.tins.2004.02.012 |
| format | Article |
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| ispartof | Trends in neurosciences (Regular ed.), 2004-04, Vol.27 (4), p.210-217 |
| issn | 0166-2236 1878-108X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Brain Cell membranes. Ionic channels. Membrane pores Cell structures and functions Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Mammals Membrane Potentials - physiology Membranes Molecular and cellular biology Neurons Neurons - metabolism Potassium Potassium Channels - classification Potassium Channels - metabolism Presynaptic Terminals - metabolism Vertebrates: nervous system and sense organs |
| title | Presynaptic K + channels: electrifying regulators of synaptic terminal excitability |
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