A single major chromosomal region controls natural killer cell-like activity in rainbow trout
We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by andr...
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| Veröffentlicht in: | Immunogenetics (New York) 2004-03, Vol.55 (12), p.825-835 |
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| creator | Zimmerman, Anastasia M Evenhuis, Jason P Thorgaard, Gary H Ristow, Sandra S |
| description | We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model. |
| doi_str_mv | 10.1007/s00251-004-0645-6 |
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A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model.</description><identifier>ISSN: 0093-7711</identifier><identifier>EISSN: 1432-1211</identifier><identifier>DOI: 10.1007/s00251-004-0645-6</identifier><identifier>PMID: 14968267</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Androgenesis ; Animals ; Chromium ; Chromium - metabolism ; Chromosome Mapping ; Chromosomes - genetics ; Female ; Fish ; Fish diseases ; Gene mapping ; Genetics ; Genomics ; Genotype ; Genotypes ; Haploidy ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - immunology ; Infectious pancreatic necrosis virus ; Killer Cells, Natural - immunology ; Lod Score ; Male ; Microsatellite Repeats ; Oncorhynchus mykiss ; Oncorhynchus mykiss - genetics ; Polymorphism, Restriction Fragment Length ; Quantitative Trait, Heritable ; Salmon</subject><ispartof>Immunogenetics (New York), 2004-03, Vol.55 (12), p.825-835</ispartof><rights>Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-22e3ed80580c0908cf9697fc40dd870b06c89f17ae603aea1ee2c52ecc8770873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14968267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimmerman, Anastasia M</creatorcontrib><creatorcontrib>Evenhuis, Jason P</creatorcontrib><creatorcontrib>Thorgaard, Gary H</creatorcontrib><creatorcontrib>Ristow, Sandra S</creatorcontrib><title>A single major chromosomal region controls natural killer cell-like activity in rainbow trout</title><title>Immunogenetics (New York)</title><addtitle>Immunogenetics</addtitle><description>We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model.</description><subject>Androgenesis</subject><subject>Animals</subject><subject>Chromium</subject><subject>Chromium - metabolism</subject><subject>Chromosome Mapping</subject><subject>Chromosomes - genetics</subject><subject>Female</subject><subject>Fish</subject><subject>Fish diseases</subject><subject>Gene mapping</subject><subject>Genetics</subject><subject>Genomics</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Haploidy</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Infectious pancreatic necrosis virus</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lod Score</subject><subject>Male</subject><subject>Microsatellite Repeats</subject><subject>Oncorhynchus mykiss</subject><subject>Oncorhynchus mykiss - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Quantitative Trait, Heritable</subject><subject>Salmon</subject><issn>0093-7711</issn><issn>1432-1211</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU2LFDEQhoO4uOPqD_AiwcPeolVJdz6Oy6KrsOBFjxIymeo1s-nOmnQr---3hxkQvHgqKJ73pYqHsTcI7xHAfGgAskcB0AnQXS_0M7bBTkmBEvE52wA4JYxBPGcvW9sDYO-kfsHOsXPaSm027McVb2m6y8THsC-Vx5-1jKWVMWRe6S6ViccyzbXkxqcwL3Xd36ecaUUpZ5HTPfEQ5_Q7zY88TbyGNG3LH75GlvkVOxtCbvT6NC_Y908fv11_Frdfb75cX92K2EmchZSkaGehtxDBgY2D084MsYPdzhrYgo7WDWgCaVCBAhLJ2EuK0RoD1qgLdnnsfajl10Jt9mNqh_vCRGVp3qDR2rr_g2gcKCXtCr77B9yXpU7rE15LJbuut7hCeIRiLa1VGvxDTWOojx7BHwz5oyG_GvIHQ16vmben4mU70u5v4qREPQEi34wB</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Zimmerman, Anastasia M</creator><creator>Evenhuis, Jason P</creator><creator>Thorgaard, Gary H</creator><creator>Ristow, Sandra S</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>A single major chromosomal region controls natural killer cell-like activity in rainbow trout</title><author>Zimmerman, Anastasia M ; Evenhuis, Jason P ; Thorgaard, Gary H ; Ristow, Sandra S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-22e3ed80580c0908cf9697fc40dd870b06c89f17ae603aea1ee2c52ecc8770873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Androgenesis</topic><topic>Animals</topic><topic>Chromium</topic><topic>Chromium - metabolism</topic><topic>Chromosome Mapping</topic><topic>Chromosomes - genetics</topic><topic>Female</topic><topic>Fish</topic><topic>Fish diseases</topic><topic>Gene mapping</topic><topic>Genetics</topic><topic>Genomics</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Haploidy</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Infectious pancreatic necrosis virus</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lod Score</topic><topic>Male</topic><topic>Microsatellite Repeats</topic><topic>Oncorhynchus mykiss</topic><topic>Oncorhynchus mykiss - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Quantitative Trait, Heritable</topic><topic>Salmon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimmerman, Anastasia M</creatorcontrib><creatorcontrib>Evenhuis, Jason P</creatorcontrib><creatorcontrib>Thorgaard, Gary H</creatorcontrib><creatorcontrib>Ristow, Sandra S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunogenetics (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimmerman, Anastasia M</au><au>Evenhuis, Jason P</au><au>Thorgaard, Gary H</au><au>Ristow, Sandra S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A single major chromosomal region controls natural killer cell-like activity in rainbow trout</atitle><jtitle>Immunogenetics (New York)</jtitle><addtitle>Immunogenetics</addtitle><date>2004-03</date><risdate>2004</risdate><volume>55</volume><issue>12</issue><spage>825</spage><epage>835</epage><pages>825-835</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><abstract>We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>14968267</pmid><doi>10.1007/s00251-004-0645-6</doi><tpages>11</tpages></addata></record> |
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| subjects | Androgenesis Animals Chromium Chromium - metabolism Chromosome Mapping Chromosomes - genetics Female Fish Fish diseases Gene mapping Genetics Genomics Genotype Genotypes Haploidy Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Infectious pancreatic necrosis virus Killer Cells, Natural - immunology Lod Score Male Microsatellite Repeats Oncorhynchus mykiss Oncorhynchus mykiss - genetics Polymorphism, Restriction Fragment Length Quantitative Trait, Heritable Salmon |
| title | A single major chromosomal region controls natural killer cell-like activity in rainbow trout |
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