Long-Term Treatment of Anterior Pituitary Cells with Nitric Oxide Induces Programmed Cell Death

Nitric oxide (NO) plays a complex role in modulating programmed cell death. It can either protect the cell from apoptotic death or mediate apoptosis, depending on its concentration and the cell type and/or status. In this study, we demonstrate that long-term exposition to NO induces cell death of an...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-04, Vol.145 (4), p.2064-2070
Hauptverfasser:	Velardez, Miguel Omar, Poliandri, Ariel Hernán, Cabilla, Jimena Paula, Bodo, Cristian Carlos Armando, Machiavelli, Leticia Inés, Duvilanski, Beatriz Haydeé
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Caspase-3 Caspase-9 Cell death Cell viability Cells, Cultured Chromatin Cytotoxicity DNA fragmentation Drug Administration Schedule Exposure Female Fragmentation Fundamental and applied biological sciences. Psychology Mortality Nitric oxide Nitric Oxide - administration & dosage Nitric Oxide Donors - pharmacology Nitroso Compounds - pharmacology Oxidative stress Pituitary (anterior) Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - physiology Prolactin Prolactin - antagonists & inhibitors Prolactin - metabolism Rats Rats, Wistar Vertebrates: endocrinology
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