Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse
We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes if raised on a high-fat diet. Because high fat feeding is associated with hyperphagia, the present study was designed to separate the effects of fat from those of excess caloric consumption in this animal model....
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2004-04, Vol.53 (4), p.454-457 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Petro, Ann E Cotter, Juliann Cooper, Dale A Peters, John C Surwit, Sarah J Surwit, Richard S |
| description | We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes if raised on a high-fat diet. Because high fat feeding is associated with hyperphagia, the present study was designed to separate the effects of fat from those of excess caloric consumption in this animal model. B6 mice were fed a low-fat diet (LF group) diet, high-fat diet (HF group) diet, or high-fat-restricted diet (HFR group), in which intake animals were pair-fed a high-fat diet to caloric level consumed by LF for 11 weeks. Within 3 weeks, HFR were significantly heavier than LF and, after 11 weeks, weight and glucose levels, but not insulin, were significantly increased in HFR when compared to LF. Body composition analysis showed the weight increase in HFR arose from an increase in percent fat conumed. We conclude that reducing the number of kilocalories consumed from a high-fat diet attenuates but does not prevent the development of type 2 diabetes and obesity in the B6 mouse. |
| doi_str_mv | 10.1016/j.metabol.2003.11.018 |
| format | Article |
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Because high fat feeding is associated with hyperphagia, the present study was designed to separate the effects of fat from those of excess caloric consumption in this animal model. B6 mice were fed a low-fat diet (LF group) diet, high-fat diet (HF group) diet, or high-fat-restricted diet (HFR group), in which intake animals were pair-fed a high-fat diet to caloric level consumed by LF for 11 weeks. Within 3 weeks, HFR were significantly heavier than LF and, after 11 weeks, weight and glucose levels, but not insulin, were significantly increased in HFR when compared to LF. Body composition analysis showed the weight increase in HFR arose from an increase in percent fat conumed. We conclude that reducing the number of kilocalories consumed from a high-fat diet attenuates but does not prevent the development of type 2 diabetes and obesity in the B6 mouse.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2003.11.018</identifier><identifier>PMID: 15045691</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Composition ; Body Weight ; Caloric Restriction ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Diet, Fat-Restricted ; Dietary Carbohydrates - adverse effects ; Dietary Carbohydrates - pharmacology ; Dietary Fats - adverse effects ; Dietary Fats - pharmacology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Male ; Medical sciences ; Metabolic diseases ; Mice ; Mice, Inbred C57BL ; Obesity ; Obesity - blood ; Obesity - metabolism</subject><ispartof>Metabolism, clinical and experimental, 2004-04, Vol.53 (4), p.454-457</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-e0ed8aa2b8714e1384caaadcb223cae874a7d378ebba6a85698a0318731439a3</citedby><cites>FETCH-LOGICAL-c457t-e0ed8aa2b8714e1384caaadcb223cae874a7d378ebba6a85698a0318731439a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.metabol.2003.11.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15662781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15045691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petro, Ann E</creatorcontrib><creatorcontrib>Cotter, Juliann</creatorcontrib><creatorcontrib>Cooper, Dale A</creatorcontrib><creatorcontrib>Peters, John C</creatorcontrib><creatorcontrib>Surwit, Sarah J</creatorcontrib><creatorcontrib>Surwit, Richard S</creatorcontrib><title>Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes if raised on a high-fat diet. Because high fat feeding is associated with hyperphagia, the present study was designed to separate the effects of fat from those of excess caloric consumption in this animal model. B6 mice were fed a low-fat diet (LF group) diet, high-fat diet (HF group) diet, or high-fat-restricted diet (HFR group), in which intake animals were pair-fed a high-fat diet to caloric level consumed by LF for 11 weeks. Within 3 weeks, HFR were significantly heavier than LF and, after 11 weeks, weight and glucose levels, but not insulin, were significantly increased in HFR when compared to LF. Body composition analysis showed the weight increase in HFR arose from an increase in percent fat conumed. We conclude that reducing the number of kilocalories consumed from a high-fat diet attenuates but does not prevent the development of type 2 diabetes and obesity in the B6 mouse.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition</subject><subject>Body Weight</subject><subject>Caloric Restriction</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet, Fat-Restricted</subject><subject>Dietary Carbohydrates - adverse effects</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Dietary Fats - adverse effects</subject><subject>Dietary Fats - pharmacology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2P0zAQhi0EYsvCTwDlAqdNdhwntntCS8XyoUpc9m4m9lTrKomL7a7Uf4-rBsGN00gzz8y8ehh7y6HhwOXtvpko4xDGpgUQDecNcP2MrXgv2lpLgOdsBdDKGrp1f8VepbQHAKW0fMmueA9dL9d8xX7eY76pLMYhPJ5cxEw3Fc6udMYQPaXKz1V-pMrRE43hMNGcq7CrnMeBchmf2TBQ8vn0B9306tP2Vn6vpnBM9Jq92OGY6M1Sr9nD_eeHzdd6--PLt83dtrZdr3JNQE4jtoNWvCMudGcR0dmhbYVF0qpD5YTSNAwoUZfwGkFwrQTvxBrFNftwOXuI4deRUjaTT5bGEWcqMYziSkrQsoD9BbQxpBRpZw7RTxhPhoM5mzV7s5g1Z7OGc1PMlr13y4PjMJH7u7WoLMD7BcBU7O0iztanfzgpW6XP3McLR8XGk6dokvU0W3I-ks3GBf-fKL8BRDSYvw</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Petro, Ann E</creator><creator>Cotter, Juliann</creator><creator>Cooper, Dale A</creator><creator>Peters, John C</creator><creator>Surwit, Sarah J</creator><creator>Surwit, Richard S</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse</title><author>Petro, Ann E ; Cotter, Juliann ; Cooper, Dale A ; Peters, John C ; Surwit, Sarah J ; Surwit, Richard S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-e0ed8aa2b8714e1384caaadcb223cae874a7d378ebba6a85698a0318731439a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Composition</topic><topic>Body Weight</topic><topic>Caloric Restriction</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet, Fat-Restricted</topic><topic>Dietary Carbohydrates - adverse effects</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Dietary Fats - adverse effects</topic><topic>Dietary Fats - pharmacology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petro, Ann E</creatorcontrib><creatorcontrib>Cotter, Juliann</creatorcontrib><creatorcontrib>Cooper, Dale A</creatorcontrib><creatorcontrib>Peters, John C</creatorcontrib><creatorcontrib>Surwit, Sarah J</creatorcontrib><creatorcontrib>Surwit, Richard S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petro, Ann E</au><au>Cotter, Juliann</au><au>Cooper, Dale A</au><au>Peters, John C</au><au>Surwit, Sarah J</au><au>Surwit, Richard S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>53</volume><issue>4</issue><spage>454</spage><epage>457</epage><pages>454-457</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes if raised on a high-fat diet. 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| subjects | Animals Biological and medical sciences Blood Glucose - metabolism Body Composition Body Weight Caloric Restriction Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diet, Fat-Restricted Dietary Carbohydrates - adverse effects Dietary Carbohydrates - pharmacology Dietary Fats - adverse effects Dietary Fats - pharmacology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Male Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Obesity Obesity - blood Obesity - metabolism |
| title | Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse |
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