Role of the phosphatidylinositol-specific phospholipase C pathway in δ-opioid receptor-mediated antinociception in the mouse spinal cord

Stimulation of δ-opioid receptors has been shown to activate phospholipase C via the activation of G-proteins in vitro. The present study was designed to determine, with the tail-flick method, whether the stimulatory effect of δ-opioid receptor agonists on phospholipase C and inositol lipid turnover...

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Veröffentlicht in:	Neuroscience 2000-01, Vol.99 (2), p.327-331
Hauptverfasser:	Narita, M, Ohsawa, M, Mizoguchi, H, Aoki, T, Suzuki, T, Tseng, L.F
Format:	Artikel
Sprache:	eng
Schlagworte:	[ d-Ala 2]deltorphin II Analgesics - pharmacology Animals Biological and medical sciences Carbazoles Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Estrenes - pharmacology Fundamental and applied biological sciences. Psychology Indoles - pharmacology Inositol 1,4,5-Trisphosphate - physiology inositol trisphosphate Male Mice Mice, Inbred ICR Naphthalenes - pharmacology Oligopeptides - pharmacology Pain - physiopathology Pain Measurement - drug effects phosphatidylinositol Phosphatidylinositols - antagonists & inhibitors Phosphatidylinositols - physiology phosphoinositol hydrolysis protein kinase C Protein Kinase C - antagonists & inhibitors Pyrroles - pharmacology Pyrrolidinones - pharmacology Receptors, Opioid, delta - drug effects Receptors, Opioid, delta - physiology Signal Transduction - drug effects Signal Transduction - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - drug effects Spinal Cord - physiology Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - physiology Vertebrates: nervous system and sense organs
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