Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
The poor outcome of patients with symptomatic aortic stenosis has been well documented. 1 – 10 In view of the excellent results of aortic-valve replacement, 2 , 11 – 16 surgery is strongly recommended for these patients. 17 In contrast, the management of asymptomatic aortic stenosis remains controve...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2000-08, Vol.343 (9), p.611-617 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 617 |
|---|---|
| container_issue | 9 |
| container_start_page | 611 |
| container_title | The New England journal of medicine |
| container_volume | 343 |
| creator | Rosenhek, Raphael Binder, Thomas Porenta, Gerold Lang, Irene Christ, Günther Schemper, Michael Maurer, Gerald Baumgartner, Helmut |
| description | The poor outcome of patients with symptomatic aortic stenosis has been well documented.
1
–
10
In view of the excellent results of aortic-valve replacement,
2
,
11
–
16
surgery is strongly recommended for these patients.
17
In contrast, the management of asymptomatic aortic stenosis remains controversial.
17
The occurrence of sudden death without preceding symptoms
1
,
4
,
18
and the potential risk of irreversible myocardial damage
14
,
19
argue for early elective surgery. However, prospective studies suggest that, in the absence of preceding symptoms, sudden death may be uncommon.
20
,
21
Nevertheless, in 1997, Otto et al. reported rapid progression and poor outcomes among patients with asymptomatic aortic . . . |
| doi_str_mv | 10.1056/NEJM200008313430903 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71764844</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>58991958</sourcerecordid><originalsourceid>FETCH-LOGICAL-c641t-599fafb537c30f3d20347f8992a7696857b0d5116d4fce31093438ef61e5feca3</originalsourceid><addsrcrecordid>eNp90E1LAzEQBuAgitbqLxBkEfGiq8nma3PwUEr9olqhel7S7AS2NJua7Ar9925pQRExl7k8M5l5EToh-JpgLm5eRk_PGe5eTgllFCtMd1CPcEpTxrDYRT2MszxlUtEDdBjjfG0JU_vogGAlOMayh25fA5SVaXyIibfJpG2Md5BUdTKFTwhwlQziyi0b73RTmWTgw7pMG6h9rOIR2rN6EeF4W_vo_W70NnxIx5P7x-FgnBrBSJNypay2M06lodjSMsOUSZsrlWkplMi5nOGSEyJKZg3QbrvunhysIMAtGE376GIzdxn8RwuxKVwVDSwWugbfxkISKVjOWAfPfsG5b0Pd7VZkGVWcZ108fUQ3yAQfYwBbLEPldFgVBBfraIs_ou26Trej25mD8kfPJssOnG-BjkYvbNC1qeK3Y1JytmaXG-ZcLGqYu39__QJauop9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223955253</pqid></control><display><type>article</type><title>Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>New England Journal of Medicine</source><creator>Rosenhek, Raphael ; Binder, Thomas ; Porenta, Gerold ; Lang, Irene ; Christ, Günther ; Schemper, Michael ; Maurer, Gerald ; Baumgartner, Helmut</creator><creatorcontrib>Rosenhek, Raphael ; Binder, Thomas ; Porenta, Gerold ; Lang, Irene ; Christ, Günther ; Schemper, Michael ; Maurer, Gerald ; Baumgartner, Helmut</creatorcontrib><description>The poor outcome of patients with symptomatic aortic stenosis has been well documented.
1
–
10
In view of the excellent results of aortic-valve replacement,
2
,
11
–
16
surgery is strongly recommended for these patients.
17
In contrast, the management of asymptomatic aortic stenosis remains controversial.
17
The occurrence of sudden death without preceding symptoms
1
,
4
,
18
and the potential risk of irreversible myocardial damage
14
,
19
argue for early elective surgery. However, prospective studies suggest that, in the absence of preceding symptoms, sudden death may be uncommon.
20
,
21
Nevertheless, in 1997, Otto et al. reported rapid progression and poor outcomes among patients with asymptomatic aortic . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200008313430903</identifier><identifier>PMID: 10965007</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Aortic Valve ; Aortic Valve Stenosis - diagnostic imaging ; Aortic Valve Stenosis - mortality ; Aortic Valve Stenosis - physiopathology ; Aortic Valve Stenosis - surgery ; Biological and medical sciences ; Cardiology ; Cardiovascular disease ; Cardiovascular system ; Coronary vessels ; Disease Progression ; Female ; Follow-Up Studies ; Heart ; Heart Valve Prosthesis Implantation ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Prognosis ; Prospective Studies ; Risk ; Survival Analysis ; Ultrasonic investigative techniques ; Ultrasonography</subject><ispartof>The New England journal of medicine, 2000-08, Vol.343 (9), p.611-617</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c641t-599fafb537c30f3d20347f8992a7696857b0d5116d4fce31093438ef61e5feca3</citedby><cites>FETCH-LOGICAL-c641t-599fafb537c30f3d20347f8992a7696857b0d5116d4fce31093438ef61e5feca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200008313430903$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM200008313430903$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1477547$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10965007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenhek, Raphael</creatorcontrib><creatorcontrib>Binder, Thomas</creatorcontrib><creatorcontrib>Porenta, Gerold</creatorcontrib><creatorcontrib>Lang, Irene</creatorcontrib><creatorcontrib>Christ, Günther</creatorcontrib><creatorcontrib>Schemper, Michael</creatorcontrib><creatorcontrib>Maurer, Gerald</creatorcontrib><creatorcontrib>Baumgartner, Helmut</creatorcontrib><title>Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The poor outcome of patients with symptomatic aortic stenosis has been well documented.
1
–
10
In view of the excellent results of aortic-valve replacement,
2
,
11
–
16
surgery is strongly recommended for these patients.
17
In contrast, the management of asymptomatic aortic stenosis remains controversial.
17
The occurrence of sudden death without preceding symptoms
1
,
4
,
18
and the potential risk of irreversible myocardial damage
14
,
19
argue for early elective surgery. However, prospective studies suggest that, in the absence of preceding symptoms, sudden death may be uncommon.
20
,
21
Nevertheless, in 1997, Otto et al. reported rapid progression and poor outcomes among patients with asymptomatic aortic . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Aortic Valve</subject><subject>Aortic Valve Stenosis - diagnostic imaging</subject><subject>Aortic Valve Stenosis - mortality</subject><subject>Aortic Valve Stenosis - physiopathology</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Coronary vessels</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart Valve Prosthesis Implantation</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Survival Analysis</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90E1LAzEQBuAgitbqLxBkEfGiq8nma3PwUEr9olqhel7S7AS2NJua7Ar9925pQRExl7k8M5l5EToh-JpgLm5eRk_PGe5eTgllFCtMd1CPcEpTxrDYRT2MszxlUtEDdBjjfG0JU_vogGAlOMayh25fA5SVaXyIibfJpG2Md5BUdTKFTwhwlQziyi0b73RTmWTgw7pMG6h9rOIR2rN6EeF4W_vo_W70NnxIx5P7x-FgnBrBSJNypay2M06lodjSMsOUSZsrlWkplMi5nOGSEyJKZg3QbrvunhysIMAtGE376GIzdxn8RwuxKVwVDSwWugbfxkISKVjOWAfPfsG5b0Pd7VZkGVWcZ108fUQ3yAQfYwBbLEPldFgVBBfraIs_ou26Trej25mD8kfPJssOnG-BjkYvbNC1qeK3Y1JytmaXG-ZcLGqYu39__QJauop9</recordid><startdate>20000831</startdate><enddate>20000831</enddate><creator>Rosenhek, Raphael</creator><creator>Binder, Thomas</creator><creator>Porenta, Gerold</creator><creator>Lang, Irene</creator><creator>Christ, Günther</creator><creator>Schemper, Michael</creator><creator>Maurer, Gerald</creator><creator>Baumgartner, Helmut</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000831</creationdate><title>Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis</title><author>Rosenhek, Raphael ; Binder, Thomas ; Porenta, Gerold ; Lang, Irene ; Christ, Günther ; Schemper, Michael ; Maurer, Gerald ; Baumgartner, Helmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-599fafb537c30f3d20347f8992a7696857b0d5116d4fce31093438ef61e5feca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aortic Valve</topic><topic>Aortic Valve Stenosis - diagnostic imaging</topic><topic>Aortic Valve Stenosis - mortality</topic><topic>Aortic Valve Stenosis - physiopathology</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>Coronary vessels</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Heart Valve Prosthesis Implantation</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Survival Analysis</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenhek, Raphael</creatorcontrib><creatorcontrib>Binder, Thomas</creatorcontrib><creatorcontrib>Porenta, Gerold</creatorcontrib><creatorcontrib>Lang, Irene</creatorcontrib><creatorcontrib>Christ, Günther</creatorcontrib><creatorcontrib>Schemper, Michael</creatorcontrib><creatorcontrib>Maurer, Gerald</creatorcontrib><creatorcontrib>Baumgartner, Helmut</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenhek, Raphael</au><au>Binder, Thomas</au><au>Porenta, Gerold</au><au>Lang, Irene</au><au>Christ, Günther</au><au>Schemper, Michael</au><au>Maurer, Gerald</au><au>Baumgartner, Helmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2000-08-31</date><risdate>2000</risdate><volume>343</volume><issue>9</issue><spage>611</spage><epage>617</epage><pages>611-617</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>The poor outcome of patients with symptomatic aortic stenosis has been well documented.
1
–
10
In view of the excellent results of aortic-valve replacement,
2
,
11
–
16
surgery is strongly recommended for these patients.
17
In contrast, the management of asymptomatic aortic stenosis remains controversial.
17
The occurrence of sudden death without preceding symptoms
1
,
4
,
18
and the potential risk of irreversible myocardial damage
14
,
19
argue for early elective surgery. However, prospective studies suggest that, in the absence of preceding symptoms, sudden death may be uncommon.
20
,
21
Nevertheless, in 1997, Otto et al. reported rapid progression and poor outcomes among patients with asymptomatic aortic . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>10965007</pmid><doi>10.1056/NEJM200008313430903</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2000-08, Vol.343 (9), p.611-617 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71764844 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Aged Aortic Valve Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - mortality Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery Biological and medical sciences Cardiology Cardiovascular disease Cardiovascular system Coronary vessels Disease Progression Female Follow-Up Studies Heart Heart Valve Prosthesis Implantation Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Multivariate Analysis Prognosis Prospective Studies Risk Survival Analysis Ultrasonic investigative techniques Ultrasonography |
| title | Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T07%3A53%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictors%20of%20Outcome%20in%20Severe,%20Asymptomatic%20Aortic%20Stenosis&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Rosenhek,%20Raphael&rft.date=2000-08-31&rft.volume=343&rft.issue=9&rft.spage=611&rft.epage=617&rft.pages=611-617&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJM200008313430903&rft_dat=%3Cproquest_cross%3E58991958%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223955253&rft_id=info:pmid/10965007&rfr_iscdi=true |