Flt3 Ligand Preferentially Increases the Number of Functionally Active Myeloid Dendritic Cells in the Lungs of Mice

In the present study, we investigated the effects of in vivo Flt3L administration on the generation, phenotype, and function of lung dendritic cells (DCs) to evaluate whether Flt3L favors the expansion and maturation of a particular DC subset. Injection of Flt3L into mice resulted in an increased nu...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-04, Vol.172 (7), p.4077-4083
Hauptverfasser:	Masten, Barbara J, Olson, Gwyneth K, Kusewitt, Donna F, Lipscomb, Mary F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - physiology Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism CD11c Antigen - biosynthesis Cell Division - genetics Cell Division - immunology Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Female Histocompatibility Antigens Class II - biosynthesis Injections, Intraperitoneal Interphase - genetics Interphase - immunology Leukocyte Common Antigens - biosynthesis Leukocyte Count Ligands Lung - cytology Lung - metabolism Membrane Proteins - administration & dosage Membrane Proteins - physiology Mice Mice, Inbred BALB C Mice, Transgenic Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - metabolism T-Lymphocytes - cytology T-Lymphocytes - immunology Up-Regulation - immunology
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