Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model

Phospholipid vesicles encapsulating Hb (Hb-vesicles: HbV) have been developed for use as artificial O 2 carriers (250 nm φ). As one of the safety evaluations, we analyzed the influence of HbV on the organ functions by laboratory tests of plasma on a total of 29 analytes. The HbV suspension ([Hb]=10...

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Veröffentlicht in:	Biomaterials 2004-08, Vol.25 (18), p.4317-4325
Hauptverfasser:	Sakai, Hiromi, Horinouchi, Hirohisa, Masada, Yohei, Takeoka, Shinji, Ikeda, Eiji, Takaori, Masuhiko, Kobayashi, Koichi, Tsuchida, Eishun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic material Blood Blood Substitutes - administration & dosage Blood Substitutes - chemistry Blood Substitutes - pharmacokinetics Drug Carriers - administration & dosage Drug Carriers - chemistry Drug delivery Drug Delivery Systems - methods Hemoglobins - administration & dosage Hemoglobins - chemistry Hepatitis B virus In vivo test Injections, Intravenous Liposome Liposomes - administration & dosage Liposomes - chemistry Liposomes - pharmacokinetics Liver - drug effects Liver - metabolism Male Metabolic Clearance Rate Nanoparticle Organ Specificity Oxygen - metabolism Pancreas - cytology Pancreas - drug effects Pancreas - metabolism Rats Rats, Wistar
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