Frontline: Induction of apoptosis and modulation of c‐FLIPL and p53 in immature dendritic cells infected with herpes simplex virus

Herpes simplex virus (HSV) can perturb the function of dendritic cells (DC). The underlying mechanisms are not defined. In the present study we demonstrate that HSV induces a substantial number of immature DC to undergo apoptosis by a mechanism involving caspase‐8. We found strongly enhanced express...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2004-04, Vol.34 (4), p.941-951
Hauptverfasser:	Müller, Dagmar B., Raftery, Martin J., Kather, Angela, Giese, Thomas, Schönrich, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - immunology Apoptosis Regulatory Proteins Blotting, Western Carrier Proteins - immunology CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 8 Caspases - metabolism c‐FLIP Dendritic cell Dendritic Cells - immunology Dendritic Cells - virology fas Receptor - metabolism Flow Cytometry Herpes Simplex - immunology Herpes simplex virus Humans Immune evasion Immunohistochemistry Intracellular Signaling Peptides and Proteins Membrane Glycoproteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Simplexvirus - immunology TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - metabolism Tumor Suppressor Protein p53 - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!