Endothelin-1: a new target of therapeutic intervention for the treatment of heart failure

Endothelin-1 has been appreciated in animals and humans as a potential target for inhibition in patients with acutely decompensated congestive heart failure (CHF), as well as patients with a chronic low-output state. There has been intense interest in determining the effects of endothelin-1 on the c...

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Veröffentlicht in:	Current opinion in cardiology 2000-05, Vol.15 (3), p.136-140
Hauptverfasser:	Duchman, Stanley M, Thohan, Vinay, Kalra, Dinesh, Torre-Amione, Guillermo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Disease Progression Dogs Drug Evaluation, Preclinical Endothelin-1 - antagonists & inhibitors Endothelin-1 - drug effects Endothelin-1 - physiology Heart Failure - drug therapy Heart Failure - etiology Heart Failure - metabolism Heart Failure - physiopathology Hemodynamics - drug effects Humans Oxygen Consumption Prognosis Pyridines - pharmacology Pyridines - therapeutic use Rabbits Rats Survival Analysis Tetrazoles - pharmacology Tetrazoles - therapeutic use
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