High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease
Treatment of high blood pressure (BP) has not produced the expected reduction in risk of ischemic heart disease (IHD). Subjects with high BP often have the metabolic syndrome X, an aggregation of abnormalities in glucose and lipid metabolism. We tested the hypothesis that the BP level would be less...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-08, Vol.36 (2), p.226-232 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Jeppesen, Jørgen Hein, Hans Ole Suadicani, Poul Gyntelberg, Finn |
| description | Treatment of high blood pressure (BP) has not produced the expected reduction in risk of ischemic heart disease (IHD). Subjects with high BP often have the metabolic syndrome X, an aggregation of abnormalities in glucose and lipid metabolism. We tested the hypothesis that the BP level would be less predictive of risk of IHD in those with high triglycerides (TG) and low HDL cholesterol (HDL-C), the characteristic dyslipidemia in the metabolic syndrome than in those without. Baseline measurements of fasting lipids, systolic BP (SBP), diastolic BP (DBP), and other risk factors were obtained in 2906 men, age 53 to 74 years, free of overt cardiovascular disease. High TG/low HDL-C was defined as TG >1.59 mmol/L and HDL-C |
| doi_str_mv | 10.1161/01.hyp.36.2.226 |
| format | Article |
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Subjects with high BP often have the metabolic syndrome X, an aggregation of abnormalities in glucose and lipid metabolism. We tested the hypothesis that the BP level would be less predictive of risk of IHD in those with high triglycerides (TG) and low HDL cholesterol (HDL-C), the characteristic dyslipidemia in the metabolic syndrome than in those without. Baseline measurements of fasting lipids, systolic BP (SBP), diastolic BP (DBP), and other risk factors were obtained in 2906 men, age 53 to 74 years, free of overt cardiovascular disease. High TG/low HDL-C was defined as TG >1.59 mmol/L and HDL-C <1.18 mmol/L. Within an 8-year period, 229 men developed IHD. In men with high TG/low HDL-C, the incidence of IHD according to SBP (<120, 120 to 140, >140 mm Hg) was 12.5%, 12.9%, and 10.0% (P =NS), respectively, and according to DBP, the incidence of IHD was (<75, 75 to 90, >90 mm Hg) 13.7%, 10.6%, and 13.7% (P =NS), respectively. The corresponding figures for other men were 5.2%, 8.0%, and 9.7% for SBP (P <0.001), and 6.1%, 7.5%, and 9.9% for DBP (P <0.03). In conclusion, the BP level did not predict the risk of IHD in those with high TG/low HDL-C. This finding may explain the reason lowering BP has not produced the expected reduction in IHD.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.hyp.36.2.226</identifier><identifier>PMID: 10948082</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Aged ; Antihypertensive Agents - therapeutic use ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; Cholesterol, HDL - blood ; Coronary heart disease ; Diastole ; Drug Therapy - statistics & numerical data ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Ischemia - blood ; Myocardial Ischemia - physiopathology ; Risk Factors ; Systole ; Triglycerides - blood</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2000-08, Vol.36 (2), p.226-232</ispartof><rights>2000 American Heart Association, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. 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Subjects with high BP often have the metabolic syndrome X, an aggregation of abnormalities in glucose and lipid metabolism. We tested the hypothesis that the BP level would be less predictive of risk of IHD in those with high triglycerides (TG) and low HDL cholesterol (HDL-C), the characteristic dyslipidemia in the metabolic syndrome than in those without. Baseline measurements of fasting lipids, systolic BP (SBP), diastolic BP (DBP), and other risk factors were obtained in 2906 men, age 53 to 74 years, free of overt cardiovascular disease. High TG/low HDL-C was defined as TG >1.59 mmol/L and HDL-C <1.18 mmol/L. Within an 8-year period, 229 men developed IHD. In men with high TG/low HDL-C, the incidence of IHD according to SBP (<120, 120 to 140, >140 mm Hg) was 12.5%, 12.9%, and 10.0% (P =NS), respectively, and according to DBP, the incidence of IHD was (<75, 75 to 90, >90 mm Hg) 13.7%, 10.6%, and 13.7% (P =NS), respectively. The corresponding figures for other men were 5.2%, 8.0%, and 9.7% for SBP (P <0.001), and 6.1%, 7.5%, and 9.9% for DBP (P <0.03). In conclusion, the BP level did not predict the risk of IHD in those with high TG/low HDL-C. This finding may explain the reason lowering BP has not produced the expected reduction in IHD.</description><subject>Aged</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol, HDL - blood</subject><subject>Coronary heart disease</subject><subject>Diastole</subject><subject>Drug Therapy - statistics & numerical data</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Risk Factors</subject><subject>Systole</subject><subject>Triglycerides - blood</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNFrFDEQxoMo9qw--yZBxLfdZpJsNvuoV-sWDixSQZ9iLjvb3TZ3OZNbjvvvm94dKA58zDD85mP4CHkLrARQcMGgHPabUqiSl5yrZ2QGFZeFrJR4TmYMGlk0AD_PyKuU7hkDKWX9kpwBa6Rmms_I73a8G-htHO_83mEcO0zUrju6CDvaXi7ofAge0xZj8If9Zx9CR28ipjRFPKy-j-mBhp5eJzfganS0RRu39HJMaBO-Ji966xO-OfVz8uPqy-28LRbfvl7PPy0KV2ktCiuxFqxW0ImlQqc6u-S86zViVYGVzPV1rZjW3IFYasVtX_GmYaIHzareVuKcfDz6bmL4M-WXzWpMDr23awxTMjXUKicEGXz_H3gfprjOvxnODqZMZejiCLkYUorYm00cVzbuDTDzlLxhYNpfN0Yow032zRfvTrbTcoXdP_wx6gx8OAE2Oev7aNduTH85WdcgRMbkEdsFn2NPD37aYTQDWr8dDMsludIFf5p0VpGV7x4B_-yZMw</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Jeppesen, Jørgen</creator><creator>Hein, Hans Ole</creator><creator>Suadicani, Poul</creator><creator>Gyntelberg, Finn</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease</title><author>Jeppesen, Jørgen ; Hein, Hans Ole ; Suadicani, Poul ; Gyntelberg, Finn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5883-a4e730761d3b6ec6dab22df8ee551a40cf7760882c13b862af529903f1805fa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol, HDL - blood</topic><topic>Coronary heart disease</topic><topic>Diastole</topic><topic>Drug Therapy - statistics & numerical data</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - blood</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Risk Factors</topic><topic>Systole</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeppesen, Jørgen</creatorcontrib><creatorcontrib>Hein, Hans Ole</creatorcontrib><creatorcontrib>Suadicani, Poul</creatorcontrib><creatorcontrib>Gyntelberg, Finn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeppesen, Jørgen</au><au>Hein, Hans Ole</au><au>Suadicani, Poul</au><au>Gyntelberg, Finn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2000-08</date><risdate>2000</risdate><volume>36</volume><issue>2</issue><spage>226</spage><epage>232</epage><pages>226-232</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Treatment of high blood pressure (BP) has not produced the expected reduction in risk of ischemic heart disease (IHD). Subjects with high BP often have the metabolic syndrome X, an aggregation of abnormalities in glucose and lipid metabolism. We tested the hypothesis that the BP level would be less predictive of risk of IHD in those with high triglycerides (TG) and low HDL cholesterol (HDL-C), the characteristic dyslipidemia in the metabolic syndrome than in those without. Baseline measurements of fasting lipids, systolic BP (SBP), diastolic BP (DBP), and other risk factors were obtained in 2906 men, age 53 to 74 years, free of overt cardiovascular disease. High TG/low HDL-C was defined as TG >1.59 mmol/L and HDL-C <1.18 mmol/L. Within an 8-year period, 229 men developed IHD. In men with high TG/low HDL-C, the incidence of IHD according to SBP (<120, 120 to 140, >140 mm Hg) was 12.5%, 12.9%, and 10.0% (P =NS), respectively, and according to DBP, the incidence of IHD was (<75, 75 to 90, >90 mm Hg) 13.7%, 10.6%, and 13.7% (P =NS), respectively. The corresponding figures for other men were 5.2%, 8.0%, and 9.7% for SBP (P <0.001), and 6.1%, 7.5%, and 9.9% for DBP (P <0.03). In conclusion, the BP level did not predict the risk of IHD in those with high TG/low HDL-C. This finding may explain the reason lowering BP has not produced the expected reduction in IHD.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>10948082</pmid><doi>10.1161/01.hyp.36.2.226</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 2000-08, Vol.36 (2), p.226-232 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Cholesterol, HDL - blood Coronary heart disease Diastole Drug Therapy - statistics & numerical data Follow-Up Studies Heart Humans Male Medical sciences Middle Aged Myocardial Ischemia - blood Myocardial Ischemia - physiopathology Risk Factors Systole Triglycerides - blood |
| title | High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease |
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