Isoflavones stimulate estrogen receptor-mediated core histone acetylation

The isoflavones genistein and daidzein and the daidzein metabolite equol have been reported to interact with estrogen receptors (ERs). Some studies indicate that they behave clinically like estrogen in some estrogen-deficiency diseases. However, the detailed molecular mechanism used by these compoun...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-04, Vol.317 (1), p.259-264
Hauptverfasser:	Hong, Tao, Nakagawa, Takeya, Pan, WeiJun, Kim, Mi Young, Lee Kraus, W, Ikehara, Tsuyoshi, Yasui, Kiyoshi, Aihara, Hitoshi, Takebe, Minoru, Muramatsu, Masami, Ito, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Acetyltransferases - metabolism AglyMax Animals Cell Line Daidzein Drosophila - chemistry Equol Estradiol Estradiol - analogs & derivatives Estradiol - metabolism Estradiol - pharmacology Estrogen Antagonists - pharmacology Estrogen receptor Genistein Genistein - pharmacology Histone acetylation Histone Acetyltransferases Histones - chemistry Histones - metabolism Isoflavones - chemistry Isoflavones - pharmacology Nuclear Proteins - metabolism Nuclear Receptor Coactivator 2 Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Spodoptera - cytology Tamoxifen - pharmacology Trans-Activators - metabolism Transcription Factors - metabolism Transcription, Genetic
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