The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors

Several clinical trials in human neoplasms have demonstrated the effectiveness of combination therapy with 5-fluorouracil (FUra), cisplatin (CDDP), and leucovorin (LV). Thymidylate synthase (TS), the target enzyme of FUra, and dihydropyrimidine dehydrogenase (DPD), the rate-limiting catabolic enzyme...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2004-04, Vol.53 (4), p.296-304
Hauptverfasser:	KOGURE, Takayuki, UENO, Yoshiyuki, IWASAKI, Takao, SHIMOSEGAWA, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Cell Survival - drug effects Cisplatin - therapeutic use Dihydrouracil Dehydrogenase (NADP) - biosynthesis Electrophoresis, Polyacrylamide Gel Fluorouracil - therapeutic use Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoblotting Leucovorin - therapeutic use Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Pharmacology. Drug treatments RNA, Messenger - biosynthesis Thymidylate Synthase - biosynthesis Tumor Cells, Cultured Tumors
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