Involvement of Rho-Kinase–Mediated Phosphorylation of Myosin Light Chain in Enhancement of Cerebral Vasospasm

Subarachnoid hemorrhage (SAH) often induces a long-term narrowing of the cerebral artery called cerebral vasospasm. Myosin light chain (MLC) in the spastic basilar artery was reported previously to be phosphorylated by Ca/calmodulin-dependent MLC kinase. Because Rho-kinase, which is activated by the...

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Veröffentlicht in:	Circulation research 2000-08, Vol.87 (3), p.195-200
Hauptverfasser:	Sato, Motohiko, Tani, Eiichi, Fujikawa, Hirokazu, Kaibuchi, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - administration & dosage Amides - pharmacology Animals Basilar Artery - enzymology Basilar Artery - pathology Biological and medical sciences Calcium - physiology Calmodulin - physiology Dogs Dose-Response Relationship, Drug Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Intracellular Signaling Peptides and Proteins Medical sciences Myosin Light Chains - metabolism Myosin-Light-Chain Phosphatase Neurology Phosphoprotein Phosphatases - metabolism Phosphorylation - drug effects Potassium Chloride - administration & dosage Potassium Chloride - pharmacology Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - physiology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - physiology Pyridines - administration & dosage Pyridines - pharmacology rho GTP-Binding Proteins - physiology rho-Associated Kinases Serotonin - administration & dosage Serotonin - pharmacology Subarachnoid Hemorrhage - complications Vascular diseases and vascular malformations of the nervous system Vasoconstrictor Agents - administration & dosage Vasoconstrictor Agents - pharmacology Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology Vasospasm, Intracranial - enzymology Vasospasm, Intracranial - etiology Vasospasm, Intracranial - pathology
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