Long-term Efficacy and Safety of Fluticasone Propionate Powder Administered Once or Twice Daily via Inhaler to Patients With Moderate Asthma

To evaluate the efficacy and safety of fluticasone propionate administered as a once-daily or twice-daily regimen over a period of 1 year to patients with moderate asthma. Double-blind, randomized, parallel group, and placebo-controlled phase (12 weeks) and an open-label phase (54 weeks). Multicente...

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Veröffentlicht in:Chest 2000-08, Vol.118 (2), p.303-312
Hauptverfasser: ZuWallack, Richard, Adelglass, Jeffery, Clifford, Dennis P., Duke, Susan P., Wire, Patrick D., Faris, Melissa, Harding, Stuart M.
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container_end_page 312
container_issue 2
container_start_page 303
container_title Chest
container_volume 118
creator ZuWallack, Richard
Adelglass, Jeffery
Clifford, Dennis P.
Duke, Susan P.
Wire, Patrick D.
Faris, Melissa
Harding, Stuart M.
description To evaluate the efficacy and safety of fluticasone propionate administered as a once-daily or twice-daily regimen over a period of 1 year to patients with moderate asthma. Double-blind, randomized, parallel group, and placebo-controlled phase (12 weeks) and an open-label phase (54 weeks). Multicenter study in an outpatient setting. Patients (n = 253; age,≥ 12 years) with a mean FEV1 of 67% predicted normal were stratified according to baseline therapy of maintenance inhaled corticosteroids vs β2-agonists alone. Fluticasone propionate (250μ g bid or 500 μg qd) or placebo (bid) was administered via the Diskus multidose powder inhaler (Glaxo Wellcome; Research Triangle Park, NC) for 12 weeks. During open-label treatment, patients were re-randomized to once-daily or twice-daily fluticasone propionate. Compared to placebo, fluticasone propionate administered qd or bid significantly improved FEV1 (p < 0.001), morning (p < 0.001) and evening peak expiratory flow (PEF; p < 0.001), asthma symptom scores (p ≤ 0.001), and albuterol use (p ≤ 0.001), and decreased nighttime awakenings. By the end of 12 weeks, withdrawal due to lack of efficacy was significantly higher in the placebo group than in the once-daily (p = 0.001) or twice-daily (p < 0.001) groups. When comparing the two active dosing regimens, significant differences in favor of twice-daily dosing were noted in FEV1, albuterol use, and withdrawal due to lack of efficacy. During 54 weeks of open-label treatment, FEV1 and PEF continued to improve with both regimens, and improvements seen in the first 12 weeks were maintained in patients who switched from twice-daily to once-daily dosing. Fluticasone propionate treatment over a 54-week period was well tolerated, with few drug-related adverse events, which were primarily topical effects of inhaled corticosteroids. Fluticasone propionate powder improved lung function when administered either qd or bid over a 1-year period to patients with moderate asthma, with twice-daily dosing demonstrating significantly greater improvement in some efficacy parameters than once-daily dosing over the first 12 weeks of treatment. Fluticasone propionate treatment was not associated with significant systemic effects.
doi_str_mv 10.1378/chest.118.2.303
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Double-blind, randomized, parallel group, and placebo-controlled phase (12 weeks) and an open-label phase (54 weeks). Multicenter study in an outpatient setting. Patients (n = 253; age,≥ 12 years) with a mean FEV1 of 67% predicted normal were stratified according to baseline therapy of maintenance inhaled corticosteroids vs β2-agonists alone. Fluticasone propionate (250μ g bid or 500 μg qd) or placebo (bid) was administered via the Diskus multidose powder inhaler (Glaxo Wellcome; Research Triangle Park, NC) for 12 weeks. During open-label treatment, patients were re-randomized to once-daily or twice-daily fluticasone propionate. Compared to placebo, fluticasone propionate administered qd or bid significantly improved FEV1 (p &lt; 0.001), morning (p &lt; 0.001) and evening peak expiratory flow (PEF; p &lt; 0.001), asthma symptom scores (p ≤ 0.001), and albuterol use (p ≤ 0.001), and decreased nighttime awakenings. 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Double-blind, randomized, parallel group, and placebo-controlled phase (12 weeks) and an open-label phase (54 weeks). Multicenter study in an outpatient setting. Patients (n = 253; age,≥ 12 years) with a mean FEV1 of 67% predicted normal were stratified according to baseline therapy of maintenance inhaled corticosteroids vs β2-agonists alone. Fluticasone propionate (250μ g bid or 500 μg qd) or placebo (bid) was administered via the Diskus multidose powder inhaler (Glaxo Wellcome; Research Triangle Park, NC) for 12 weeks. During open-label treatment, patients were re-randomized to once-daily or twice-daily fluticasone propionate. Compared to placebo, fluticasone propionate administered qd or bid significantly improved FEV1 (p &lt; 0.001), morning (p &lt; 0.001) and evening peak expiratory flow (PEF; p &lt; 0.001), asthma symptom scores (p ≤ 0.001), and albuterol use (p ≤ 0.001), and decreased nighttime awakenings. By the end of 12 weeks, withdrawal due to lack of efficacy was significantly higher in the placebo group than in the once-daily (p = 0.001) or twice-daily (p &lt; 0.001) groups. When comparing the two active dosing regimens, significant differences in favor of twice-daily dosing were noted in FEV1, albuterol use, and withdrawal due to lack of efficacy. During 54 weeks of open-label treatment, FEV1 and PEF continued to improve with both regimens, and improvements seen in the first 12 weeks were maintained in patients who switched from twice-daily to once-daily dosing. Fluticasone propionate treatment over a 54-week period was well tolerated, with few drug-related adverse events, which were primarily topical effects of inhaled corticosteroids. Fluticasone propionate powder improved lung function when administered either qd or bid over a 1-year period to patients with moderate asthma, with twice-daily dosing demonstrating significantly greater improvement in some efficacy parameters than once-daily dosing over the first 12 weeks of treatment. 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Double-blind, randomized, parallel group, and placebo-controlled phase (12 weeks) and an open-label phase (54 weeks). Multicenter study in an outpatient setting. Patients (n = 253; age,≥ 12 years) with a mean FEV1 of 67% predicted normal were stratified according to baseline therapy of maintenance inhaled corticosteroids vs β2-agonists alone. Fluticasone propionate (250μ g bid or 500 μg qd) or placebo (bid) was administered via the Diskus multidose powder inhaler (Glaxo Wellcome; Research Triangle Park, NC) for 12 weeks. During open-label treatment, patients were re-randomized to once-daily or twice-daily fluticasone propionate. Compared to placebo, fluticasone propionate administered qd or bid significantly improved FEV1 (p &lt; 0.001), morning (p &lt; 0.001) and evening peak expiratory flow (PEF; p &lt; 0.001), asthma symptom scores (p ≤ 0.001), and albuterol use (p ≤ 0.001), and decreased nighttime awakenings. By the end of 12 weeks, withdrawal due to lack of efficacy was significantly higher in the placebo group than in the once-daily (p = 0.001) or twice-daily (p &lt; 0.001) groups. When comparing the two active dosing regimens, significant differences in favor of twice-daily dosing were noted in FEV1, albuterol use, and withdrawal due to lack of efficacy. During 54 weeks of open-label treatment, FEV1 and PEF continued to improve with both regimens, and improvements seen in the first 12 weeks were maintained in patients who switched from twice-daily to once-daily dosing. Fluticasone propionate treatment over a 54-week period was well tolerated, with few drug-related adverse events, which were primarily topical effects of inhaled corticosteroids. Fluticasone propionate powder improved lung function when administered either qd or bid over a 1-year period to patients with moderate asthma, with twice-daily dosing demonstrating significantly greater improvement in some efficacy parameters than once-daily dosing over the first 12 weeks of treatment. Fluticasone propionate treatment was not associated with significant systemic effects.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>10936117</pmid><doi>10.1378/chest.118.2.303</doi><tpages>10</tpages></addata></record>
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subjects Administration, Inhalation
Adolescent
Adrenergic beta-Agonists - administration & dosage
Adult
Aged
Albuterol - administration & dosage
Androstadienes - administration & dosage
Anti-Asthmatic Agents - administration & dosage
asthma
Asthma - drug therapy
Asthma - physiopathology
Biological and medical sciences
Child
Circadian Rhythm
Diskus
Double-Blind Method
Drug Administration Schedule
Female
Fluticasone
fluticasone propionate
Follow-Up Studies
Forced Expiratory Volume - drug effects
Humans
long-term
Male
Medical sciences
Middle Aged
Nebulizers and Vaporizers
once-daily
Pharmacology. Drug treatments
Powders
Respiratory system
Safety
Severity of Illness Index
twice-daily
title Long-term Efficacy and Safety of Fluticasone Propionate Powder Administered Once or Twice Daily via Inhaler to Patients With Moderate Asthma
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