The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke
We studied 24 patients up to 51 hours after ischemic stroke using 18F‐fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed...
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| Veröffentlicht in: | Annals of neurology 2000-08, Vol.48 (2), p.228-235 |
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| creator | Read, S. J. Hirano, T. Abbott, D. F. Markus, R. Sachinidis, J. I. Tochon-Danguy, H. J. Chan, J. G. Egan, G. F. Scott, A. M. Bladin, C. F. McKay, W. J. Donnan, G. A. |
| description | We studied 24 patients up to 51 hours after ischemic stroke using 18F‐fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed tomography was available in 12 patients, allowing comparison with the infarct volume to determine the proportions of the hypoxic tissue volume that infarcted and survived. The proportion of patients with hypoxic tissue and the amount of hypoxic tissue detected declined with time. On average, 45% of the total hypoxic tissue volume survived and 55% infarcted. Up to 68% (mean, 17.5%) of the infarct volume was initially hypoxic. Most of the tissue “initially affected” proceeded to infarction. We correlated hypoxic tissue volumes with neurological and functional outcome assessed using the National Institutes of Health Stroke Scale, Barthel Index, and Rankin Score. Initial stroke severity correlated significantly with the “initially affected” volume, neurological deterioration during the first week after stroke with the proportion of the “initially affected” volume that infarcted, and functional outcome with the infarct volume. Significant reductions in the size of the infarct and improved clinical outcomes might be achieved if hypoxic tissue can be rescued. Ann Neurol 2000;48:228–235 |
| doi_str_mv | 10.1002/1531-8249(200008)48:2<228::AID-ANA13>3.0.CO;2-B |
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J. ; Hirano, T. ; Abbott, D. F. ; Markus, R. ; Sachinidis, J. I. ; Tochon-Danguy, H. J. ; Chan, J. G. ; Egan, G. F. ; Scott, A. M. ; Bladin, C. F. ; McKay, W. J. ; Donnan, G. A.</creator><creatorcontrib>Read, S. J. ; Hirano, T. ; Abbott, D. F. ; Markus, R. ; Sachinidis, J. I. ; Tochon-Danguy, H. J. ; Chan, J. G. ; Egan, G. F. ; Scott, A. M. ; Bladin, C. F. ; McKay, W. J. ; Donnan, G. A.</creatorcontrib><description>We studied 24 patients up to 51 hours after ischemic stroke using 18F‐fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed tomography was available in 12 patients, allowing comparison with the infarct volume to determine the proportions of the hypoxic tissue volume that infarcted and survived. The proportion of patients with hypoxic tissue and the amount of hypoxic tissue detected declined with time. On average, 45% of the total hypoxic tissue volume survived and 55% infarcted. Up to 68% (mean, 17.5%) of the infarct volume was initially hypoxic. Most of the tissue “initially affected” proceeded to infarction. We correlated hypoxic tissue volumes with neurological and functional outcome assessed using the National Institutes of Health Stroke Scale, Barthel Index, and Rankin Score. Initial stroke severity correlated significantly with the “initially affected” volume, neurological deterioration during the first week after stroke with the proportion of the “initially affected” volume that infarcted, and functional outcome with the infarct volume. Significant reductions in the size of the infarct and improved clinical outcomes might be achieved if hypoxic tissue can be rescued. 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J.</creatorcontrib><creatorcontrib>Hirano, T.</creatorcontrib><creatorcontrib>Abbott, D. F.</creatorcontrib><creatorcontrib>Markus, R.</creatorcontrib><creatorcontrib>Sachinidis, J. I.</creatorcontrib><creatorcontrib>Tochon-Danguy, H. J.</creatorcontrib><creatorcontrib>Chan, J. G.</creatorcontrib><creatorcontrib>Egan, G. F.</creatorcontrib><creatorcontrib>Scott, A. M.</creatorcontrib><creatorcontrib>Bladin, C. F.</creatorcontrib><creatorcontrib>McKay, W. J.</creatorcontrib><creatorcontrib>Donnan, G. A.</creatorcontrib><title>The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We studied 24 patients up to 51 hours after ischemic stroke using 18F‐fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed tomography was available in 12 patients, allowing comparison with the infarct volume to determine the proportions of the hypoxic tissue volume that infarcted and survived. The proportion of patients with hypoxic tissue and the amount of hypoxic tissue detected declined with time. On average, 45% of the total hypoxic tissue volume survived and 55% infarcted. Up to 68% (mean, 17.5%) of the infarct volume was initially hypoxic. Most of the tissue “initially affected” proceeded to infarction. We correlated hypoxic tissue volumes with neurological and functional outcome assessed using the National Institutes of Health Stroke Scale, Barthel Index, and Rankin Score. Initial stroke severity correlated significantly with the “initially affected” volume, neurological deterioration during the first week after stroke with the proportion of the “initially affected” volume that infarcted, and functional outcome with the infarct volume. Significant reductions in the size of the infarct and improved clinical outcomes might be achieved if hypoxic tissue can be rescued. 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J.</creator><creator>Hirano, T.</creator><creator>Abbott, D. F.</creator><creator>Markus, R.</creator><creator>Sachinidis, J. I.</creator><creator>Tochon-Danguy, H. J.</creator><creator>Chan, J. G.</creator><creator>Egan, G. F.</creator><creator>Scott, A. M.</creator><creator>Bladin, C. F.</creator><creator>McKay, W. J.</creator><creator>Donnan, G. A.</creator><general>John Wiley & Sons, Inc</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke</title><author>Read, S. J. ; Hirano, T. ; Abbott, D. F. ; Markus, R. ; Sachinidis, J. I. ; Tochon-Danguy, H. J. ; Chan, J. G. ; Egan, G. F. ; Scott, A. M. ; Bladin, C. F. ; McKay, W. J. ; Donnan, G. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1953-e5d79c954b149975553582c7c182c5aeca843d2ebfc5788f4b34f5d27f7cd2433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia-Ischemia, Brain - diagnostic imaging</topic><topic>Hypoxia-Ischemia, Brain - pathology</topic><topic>Hypoxia-Ischemia, Brain - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Misonidazole - analogs & derivatives</topic><topic>Neurology</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - pathology</topic><topic>Stroke - physiopathology</topic><topic>Time Factors</topic><topic>Tomography, Emission-Computed</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Read, S. J.</creatorcontrib><creatorcontrib>Hirano, T.</creatorcontrib><creatorcontrib>Abbott, D. F.</creatorcontrib><creatorcontrib>Markus, R.</creatorcontrib><creatorcontrib>Sachinidis, J. I.</creatorcontrib><creatorcontrib>Tochon-Danguy, H. J.</creatorcontrib><creatorcontrib>Chan, J. G.</creatorcontrib><creatorcontrib>Egan, G. F.</creatorcontrib><creatorcontrib>Scott, A. M.</creatorcontrib><creatorcontrib>Bladin, C. F.</creatorcontrib><creatorcontrib>McKay, W. J.</creatorcontrib><creatorcontrib>Donnan, G. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Read, S. J.</au><au>Hirano, T.</au><au>Abbott, D. F.</au><au>Markus, R.</au><au>Sachinidis, J. I.</au><au>Tochon-Danguy, H. J.</au><au>Chan, J. G.</au><au>Egan, G. F.</au><au>Scott, A. M.</au><au>Bladin, C. F.</au><au>McKay, W. J.</au><au>Donnan, G. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2000-08</date><risdate>2000</risdate><volume>48</volume><issue>2</issue><spage>228</spage><epage>235</epage><pages>228-235</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>We studied 24 patients up to 51 hours after ischemic stroke using 18F‐fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed tomography was available in 12 patients, allowing comparison with the infarct volume to determine the proportions of the hypoxic tissue volume that infarcted and survived. The proportion of patients with hypoxic tissue and the amount of hypoxic tissue detected declined with time. On average, 45% of the total hypoxic tissue volume survived and 55% infarcted. Up to 68% (mean, 17.5%) of the infarct volume was initially hypoxic. Most of the tissue “initially affected” proceeded to infarction. We correlated hypoxic tissue volumes with neurological and functional outcome assessed using the National Institutes of Health Stroke Scale, Barthel Index, and Rankin Score. Initial stroke severity correlated significantly with the “initially affected” volume, neurological deterioration during the first week after stroke with the proportion of the “initially affected” volume that infarcted, and functional outcome with the infarct volume. Significant reductions in the size of the infarct and improved clinical outcomes might be achieved if hypoxic tissue can be rescued. Ann Neurol 2000;48:228–235</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10939574</pmid><doi>10.1002/1531-8249(200008)48:2<228::AID-ANA13>3.0.CO;2-B</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Brain - diagnostic imaging Brain - pathology Brain - physiopathology Disease Progression Female Humans Hypoxia-Ischemia, Brain - diagnostic imaging Hypoxia-Ischemia, Brain - pathology Hypoxia-Ischemia, Brain - physiopathology Male Medical sciences Misonidazole - analogs & derivatives Neurology Stroke - diagnostic imaging Stroke - pathology Stroke - physiopathology Time Factors Tomography, Emission-Computed Vascular diseases and vascular malformations of the nervous system |
| title | The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke |
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