Identification of Mimotopes of Platelet Autoantigens Associated with Autoimmune Thrombocytopenic Purpura

GPIIb/IIIa, the human platelet glycoprotein complex, is the autoantigen most commonly recognized by autoantibodies in autoimmune thrombocytopenic purpura (AITP). Two murine monoclonal antibodies (mAbs), namely Y2/51 and 5B12, directed against gpIIIa and gpIIb/IIIa, respectively, and rabbit anti-huma...

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Veröffentlicht in:	Journal of autoimmunity 2000-08, Vol.15 (1), p.33-40
Hauptverfasser:	Gevorkian, G/, Manoutcharian, K., Govezensky, T., Cano, J.A., Dominguez, V., Santamaria, H., Larralde, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies, autoantigens, autoimmune thrombocytopenic purpura, phage display peptide library Autoantigens - analysis Bacteriophage M13 - immunology Biological and medical sciences Blood Platelets - immunology Enzyme-Linked Immunosorbent Assay Epitopes - analysis General aspects Hematologic and hematopoietic diseases Humans Immunopathology Medical sciences Mice Molecular Mimicry Oligopeptides - analysis Oligopeptides - immunology Peptide Library Peptide Mapping Platelet diseases and coagulopathies Platelet Glycoprotein GPIIb-IIIa Complex - immunology Purpura, Thrombocytopenic, Idiopathic - immunology Rabbits Sequence Homology, Amino Acid
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