Prevention of lethal respiratory vaccinia infections in mice with interferon-α and interferon-γ

The antiviral efficacy of interferons (IFNs) was evaluated using a vaccinia intranasal infection model in mice in this study. We provide evidence that intranasal administration of IFN-α and IFN-γ (days −1 to +3) resulted in 100 and 90% survival against a lethal respiratory vaccinia infection (8 LD 5...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2004-04, Vol.40 (3), p.201-206
Hauptverfasser:	Liu, Ge, Zhai, Qingzhu, Schaffner, Dustin J, Wu, Aiguo, Yohannes, Adiamseged, Robinson, Tanisha M, Maland, Matt, Wells, Jay, Voss, Thomas G, Bailey, Charlie, Alibek, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Body Weight Fundamental and applied biological sciences. Psychology Fundamental immunology Interferon-alpha - administration & dosage Interferon-alpha - pharmacology Interferon-alpha - therapeutic use Interferon-gamma - administration & dosage Interferon-gamma - pharmacology Interferon-gamma - therapeutic use Interferon-α Interferon-γ Mice Microbiology Orthopoxvirus Poxvirus Respiratory Tract Infections - mortality Respiratory Tract Infections - prevention & control Survival Analysis Tissues, organs and organisms biophysics Vaccinia - drug therapy Vaccinia - mortality Vaccinia - virology Vaccinia virus Vaccinia virus - drug effects Vaccinia virus - growth & development Viral Plaque Assay Virus Replication - drug effects
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