Protective effect of taurine on the detachment of cultured cardiac fibroblasts from the substratum induced by calcium depletion
Removal of Ca2+ from the incubation medium of cultured rat cardiac fibroblasts causes cellular morphological changes, such as the formation of blebs, the ballooning of the cell membrane and the detachment from the culture dish. A 24 hr preincubation with 20 mM taurine blocked the Ca2+ depletion-indu...
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| Veröffentlicht in: | Amino acids 2004-03, Vol.26 (2), p.159-162 |
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| creator | Azuma, M Takahashi, K Kimura, A Matsuda, T Schaffer, S W Azuma, J |
| description | Removal of Ca2+ from the incubation medium of cultured rat cardiac fibroblasts causes cellular morphological changes, such as the formation of blebs, the ballooning of the cell membrane and the detachment from the culture dish. A 24 hr preincubation with 20 mM taurine blocked the Ca2+ depletion-induced detachment of the cardiac fibroblasts. However, taurine treatment did not prevent other morphological changes induced by Ca2+ depletion. The data suggest that taurine plays an important role in cell adhesion in the heart. |
| doi_str_mv | 10.1007/s00726-003-0046-4 |
| format | Article |
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A 24 hr preincubation with 20 mM taurine blocked the Ca2+ depletion-induced detachment of the cardiac fibroblasts. However, taurine treatment did not prevent other morphological changes induced by Ca2+ depletion. The data suggest that taurine plays an important role in cell adhesion in the heart.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-003-0046-4</identifier><identifier>PMID: 15042445</identifier><language>eng</language><publisher>Austria: Springer Nature B.V</publisher><subject>Amino acids ; Animals ; Blocking ; Bulging ; Calcium ; Calcium - pharmacology ; Calcium - physiology ; Calcium Channel Blockers - pharmacology ; Cell adhesion & migration ; Cell Adhesion - drug effects ; Cells, Cultured ; Culture ; Depletion ; Detachment ; Fibroblasts ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Myocardium - cytology ; Proteins ; Rats ; Rats, Wistar ; Taurine - pharmacology</subject><ispartof>Amino acids, 2004-03, Vol.26 (2), p.159-162</ispartof><rights>Springer-Verlag/Wien 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15042445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azuma, M</creatorcontrib><creatorcontrib>Takahashi, K</creatorcontrib><creatorcontrib>Kimura, A</creatorcontrib><creatorcontrib>Matsuda, T</creatorcontrib><creatorcontrib>Schaffer, S W</creatorcontrib><creatorcontrib>Azuma, J</creatorcontrib><title>Protective effect of taurine on the detachment of cultured cardiac fibroblasts from the substratum induced by calcium depletion</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><description>Removal of Ca2+ from the incubation medium of cultured rat cardiac fibroblasts causes cellular morphological changes, such as the formation of blebs, the ballooning of the cell membrane and the detachment from the culture dish. 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The data suggest that taurine plays an important role in cell adhesion in the heart.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Blocking</subject><subject>Bulging</subject><subject>Calcium</subject><subject>Calcium - pharmacology</subject><subject>Calcium - physiology</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion - drug effects</subject><subject>Cells, Cultured</subject><subject>Culture</subject><subject>Depletion</subject><subject>Detachment</subject><subject>Fibroblasts</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Myocardium - cytology</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Taurine - pharmacology</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rHSEUhqW0NDdpf0A3RSiUbKbR0dGZZQn9gkCzSNfDUY_EMDPe-lHIKn89JvdCoYsu1IPneQ_KQ8g7zj5xxvRFbluvOsZEW1J18gXZcSnGrufT9JLs2CSmTsqBn5DTnO8Y4_3I1Wtywgcm-9bYkYfrFAvaEv4gRe9bRaOnBWoKG9K40XKL1GEBe7vi9ty0dSk1oaMWkgtgqQ8mRbNALpn6FNfnTK4mlwSlrjRsrtrGm_sWWWxoVw73C5YQtzfklYcl49vjeUZ-ff1yc_m9u_r57cfl56vOCs5KN3rQAzDnQFvFkBvnJyfBamC9BCNHw4S34yi4RmkVWI-9UgadM8LC0Isz8vEwd5_i74q5zGvIFpcFNow1z5rrYZR6bOD5f0HO-KTUIDhv6Id_0LtY09a-0ahpULq9bWoUP1A2xZwT-nmfwgrpvkHzk8b5oHFuGucnjbNsmffHydWs6P4mjt7EIxm5muE</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Azuma, M</creator><creator>Takahashi, K</creator><creator>Kimura, A</creator><creator>Matsuda, T</creator><creator>Schaffer, S W</creator><creator>Azuma, J</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Protective effect of taurine on the detachment of cultured cardiac fibroblasts from the substratum induced by calcium depletion</title><author>Azuma, M ; 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| subjects | Amino acids Animals Blocking Bulging Calcium Calcium - pharmacology Calcium - physiology Calcium Channel Blockers - pharmacology Cell adhesion & migration Cell Adhesion - drug effects Cells, Cultured Culture Depletion Detachment Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Myocardium - cytology Proteins Rats Rats, Wistar Taurine - pharmacology |
| title | Protective effect of taurine on the detachment of cultured cardiac fibroblasts from the substratum induced by calcium depletion |
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