Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins
Objectives: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD). Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CA...
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| Veröffentlicht in: | Clinical biochemistry 2000-06, Vol.33 (4), p.303-309 |
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| creator | Serdar, Zehra Sarandöl, Emre Dirican, Melahat Yeşilbursa, Dilek Serdar, Akin Tokullugil, Asuman |
| description | Objectives: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD).
Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects.
Results: In CAD patients with Lp (a) concentrations ≥ 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations ≥ 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects.
Conclusions: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels ≥ 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a). |
| doi_str_mv | 10.1016/S0009-9120(00)00079-5 |
| format | Article |
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Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects.
Results: In CAD patients with Lp (a) concentrations ≥ 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations ≥ 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects.
Conclusions: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels ≥ 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/S0009-9120(00)00079-5</identifier><identifier>PMID: 10936590</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; antioxidants ; Apolipoproteins B - blood ; Carotenoids - blood ; Coronary Angiography ; coronary artery disease ; Coronary Disease - blood ; Female ; Humans ; Lipid Peroxidation - physiology ; lipoprotein (a) ; lipoprotein oxidation ; Lipoprotein(a) - blood ; Male ; Malondialdehyde - blood ; Middle Aged ; Severity of Illness Index ; Statistics, Nonparametric ; Vitamin E - blood</subject><ispartof>Clinical biochemistry, 2000-06, Vol.33 (4), p.303-309</ispartof><rights>2000 The Canadian Society of Clinical Chemists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-69b68098b3045fae5093becfdeb1b68ea1f7012e1b52a41301e0ac5b6ced35183</citedby><cites>FETCH-LOGICAL-c361t-69b68098b3045fae5093becfdeb1b68ea1f7012e1b52a41301e0ac5b6ced35183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0009-9120(00)00079-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10936590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serdar, Zehra</creatorcontrib><creatorcontrib>Sarandöl, Emre</creatorcontrib><creatorcontrib>Dirican, Melahat</creatorcontrib><creatorcontrib>Yeşilbursa, Dilek</creatorcontrib><creatorcontrib>Serdar, Akin</creatorcontrib><creatorcontrib>Tokullugil, Asuman</creatorcontrib><title>Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Objectives: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD).
Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects.
Results: In CAD patients with Lp (a) concentrations ≥ 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations ≥ 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects.
Conclusions: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels ≥ 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).</description><subject>Adult</subject><subject>Aged</subject><subject>antioxidants</subject><subject>Apolipoproteins B - blood</subject><subject>Carotenoids - blood</subject><subject>Coronary Angiography</subject><subject>coronary artery disease</subject><subject>Coronary Disease - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Lipid Peroxidation - physiology</subject><subject>lipoprotein (a)</subject><subject>lipoprotein oxidation</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Vitamin E - blood</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtKxDAQhoMo7np4BKVXsntRnTRN21yJLp5gQfBwHdJ0KpFuUpvuqm9v1i6yd0JgMsw388_8hJxQOKdAs4tnABCxoAlMAKYhyUXMd8iYFjmLE8HYLhn_ISNy4P17SJO0yPbJiIJgGRcwJvoJG9UbZ6MS-09EGzWmdW3nejQ2mqhppGwVhe_K9J2L3JepBtzVkWrdNnwda2d7Zayxb9tT_BHZq1Xj8XgTD8nr7c3L7D6eP949zK7msWYZ7eNMlFkBoigZpLxWyMOSJeq6wpKGCipa50ATpCVPVEoZUASleZlprBinBTskZ8PcIPyxRN_LhfEam0ZZdEsvc5rzIk1FAPkA6s5532Et284sVPctKci1u_LXXbm2TsL6BXclD32nG4FlucBqq2uwMwCXA4DhzJXBTnpt0IYFTYe6l5Uz_0j8ACYlixc</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Serdar, Zehra</creator><creator>Sarandöl, Emre</creator><creator>Dirican, Melahat</creator><creator>Yeşilbursa, Dilek</creator><creator>Serdar, Akin</creator><creator>Tokullugil, Asuman</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins</title><author>Serdar, Zehra ; Sarandöl, Emre ; Dirican, Melahat ; Yeşilbursa, Dilek ; Serdar, Akin ; Tokullugil, Asuman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-69b68098b3045fae5093becfdeb1b68ea1f7012e1b52a41301e0ac5b6ced35183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>antioxidants</topic><topic>Apolipoproteins B - blood</topic><topic>Carotenoids - blood</topic><topic>Coronary Angiography</topic><topic>coronary artery disease</topic><topic>Coronary Disease - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Lipid Peroxidation - physiology</topic><topic>lipoprotein (a)</topic><topic>lipoprotein oxidation</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serdar, Zehra</creatorcontrib><creatorcontrib>Sarandöl, Emre</creatorcontrib><creatorcontrib>Dirican, Melahat</creatorcontrib><creatorcontrib>Yeşilbursa, Dilek</creatorcontrib><creatorcontrib>Serdar, Akin</creatorcontrib><creatorcontrib>Tokullugil, Asuman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serdar, Zehra</au><au>Sarandöl, Emre</au><au>Dirican, Melahat</au><au>Yeşilbursa, Dilek</au><au>Serdar, Akin</au><au>Tokullugil, Asuman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>33</volume><issue>4</issue><spage>303</spage><epage>309</epage><pages>303-309</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Objectives: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD).
Design and methods: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects.
Results: In CAD patients with Lp (a) concentrations ≥ 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations ≥ 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects.
Conclusions: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels ≥ 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10936590</pmid><doi>10.1016/S0009-9120(00)00079-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical biochemistry, 2000-06, Vol.33 (4), p.303-309 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged antioxidants Apolipoproteins B - blood Carotenoids - blood Coronary Angiography coronary artery disease Coronary Disease - blood Female Humans Lipid Peroxidation - physiology lipoprotein (a) lipoprotein oxidation Lipoprotein(a) - blood Male Malondialdehyde - blood Middle Aged Severity of Illness Index Statistics, Nonparametric Vitamin E - blood |
| title | Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins |
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