Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors

The activation of caspase-3 represents a critical step in the pathways leading to the biochemical and morphological changes that underlie apoptosis. Upon induction of apoptosis, the large (p17) and small (p12) subunits, comprising active caspase-3, are generated via proteolytic processing of a laten...

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Veröffentlicht in:	Cell death and differentiation 2004-04, Vol.11 (4), p.439-447
Hauptverfasser:	Tawa, P, Hell, K, Giroux, A, Grimm, E, Han, Y, Nicholson, D W, Xanthoudakis, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - physiology Biochemistry Biomedical and Life Sciences Caspase 3 Caspase Inhibitors Caspases - metabolism Catalysis Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Enzyme Inhibitors - pharmacology Enzyme Stability - drug effects Enzymes Gene Expression Regulation, Enzymologic - drug effects Genotype & phenotype HeLa Cells Humans Life Sciences Macromolecular Substances Molecular Structure original-paper Peptides Proteins Stem Cells Tumor Cells, Cultured
Online-Zugang:	Volltext
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