A Case of Acute Graft‐versus‐Host Disease Following Autologous Peripheral Blood Stem Cell Transplantation
A 42–year‐old woman developed severe erythema with exfoliative scaling on the bilateral palms and soles and erosive dermatitis on the axillae and groin eight days after an autologous peripheral blood stem cell transplantation for the treatment of non‐Hodgkin's lymphoma. She also developed exant...
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| Veröffentlicht in: | Journal of dermatology 2000-07, Vol.27 (7), p.446-449 |
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| creator | Tokime, Kazuya Isoda, Ken‐ichi Yamanaka, Kei‐ichi Mizutani, Hitoshi |
| description | A 42–year‐old woman developed severe erythema with exfoliative scaling on the bilateral palms and soles and erosive dermatitis on the axillae and groin eight days after an autologous peripheral blood stem cell transplantation for the treatment of non‐Hodgkin's lymphoma. She also developed exanthema; however she did not show intestinal, hepatic, or renal involvement. The skin biopsy revealed characteristic apoptotic cell death of the epidermis with eosinophilic necrosis, and she was diagnosed with acute graft‐versus‐host disease (GVHD). The cutaneous lesions responded to topical corticosteroid treatments and improved within a month without systemic immunosuppressing therapies. The cutaneous GVH reaction did not recur. However, she was treated with an intermittent thrombocyte transfusion because of persistent thrombocytopenia. On day 130, she developed intestinal pneumonia and died due to respiratory dysfunction. Unlike an allo‐bone marrow graft, GVHD after an autologous stem cell transplantation is not common. Even for an autologous transplantation, GVH may develop with less characteristic clinical manifestations. |
| doi_str_mv | 10.1111/j.1346-8138.2000.tb02203.x |
| format | Article |
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She also developed exanthema; however she did not show intestinal, hepatic, or renal involvement. The skin biopsy revealed characteristic apoptotic cell death of the epidermis with eosinophilic necrosis, and she was diagnosed with acute graft‐versus‐host disease (GVHD). The cutaneous lesions responded to topical corticosteroid treatments and improved within a month without systemic immunosuppressing therapies. The cutaneous GVH reaction did not recur. However, she was treated with an intermittent thrombocyte transfusion because of persistent thrombocytopenia. On day 130, she developed intestinal pneumonia and died due to respiratory dysfunction. Unlike an allo‐bone marrow graft, GVHD after an autologous stem cell transplantation is not common. 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She also developed exanthema; however she did not show intestinal, hepatic, or renal involvement. The skin biopsy revealed characteristic apoptotic cell death of the epidermis with eosinophilic necrosis, and she was diagnosed with acute graft‐versus‐host disease (GVHD). The cutaneous lesions responded to topical corticosteroid treatments and improved within a month without systemic immunosuppressing therapies. The cutaneous GVH reaction did not recur. However, she was treated with an intermittent thrombocyte transfusion because of persistent thrombocytopenia. On day 130, she developed intestinal pneumonia and died due to respiratory dysfunction. Unlike an allo‐bone marrow graft, GVHD after an autologous stem cell transplantation is not common. Even for an autologous transplantation, GVH may develop with less characteristic clinical manifestations.</description><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adult</subject><subject>apoptosis</subject><subject>autograft</subject><subject>bone marrow transplantation</subject><subject>Dermatitis, Exfoliative - drug therapy</subject><subject>Dermatitis, Exfoliative - etiology</subject><subject>Dermatitis, Exfoliative - pathology</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Graft vs Host Disease - diagnosis</subject><subject>Graft vs Host Disease - drug therapy</subject><subject>Graft vs Host Disease - etiology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Humans</subject><subject>lymphoma</subject><subject>Lymphoma, B-Cell - diagnosis</subject><subject>Lymphoma, B-Cell - therapy</subject><subject>Necrosis</subject><subject>Transplantation, Autologous</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkctu1DAUhi0EotMpr4AsFohNgq-xzYphegNVohJlbTmJUzJy4qnt9LLrI_QZeRIcZoRYIXE250jnOxf9PwBvMCpxjvebElNWFRJTWRKEUJlqRAii5f0zsPjTeg4WiEpeEIbEATiMcYMQURyjl-AAI0U5ZXgBhhVcm2ih7-CqmZKFZ8F06efj060NcYq5OPcxweM-2hk79c75u368hqspeeev_RThpQ399ocNxsFPzvsWfkt2gGvrHLwKZoxbZ8ZkUu_HI_CiMy7aV_u8BN9PT67W58XF17PP69VF0VCmaCGValvGCBIdw0IpUbdEVhWRzPBGcoZbU5GGSYFMrRpqueDcNkpSUYsacUqX4O1u7zb4m8nGpIc-NvkhM9r8sRZYcFHlU0vw7p8griRiWSohMvphhzbBxxhsp7ehH0x40Bjp2Re90bP4ehZfz77ovS_6Pg-_3t-Z6sG2f43ujMjAxx1w1zv78B-r9Zfjk98l_QWvbJ6t</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Tokime, Kazuya</creator><creator>Isoda, Ken‐ichi</creator><creator>Yamanaka, Kei‐ichi</creator><creator>Mizutani, Hitoshi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>A Case of Acute Graft‐versus‐Host Disease Following Autologous Peripheral Blood Stem Cell Transplantation</title><author>Tokime, Kazuya ; Isoda, Ken‐ichi ; Yamanaka, Kei‐ichi ; Mizutani, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3493-899dd44207f417997bd2866284a5c8541da62c4870ab9c3e5755ec9837b7b0533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adult</topic><topic>apoptosis</topic><topic>autograft</topic><topic>bone marrow transplantation</topic><topic>Dermatitis, Exfoliative - drug therapy</topic><topic>Dermatitis, Exfoliative - etiology</topic><topic>Dermatitis, Exfoliative - pathology</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Graft vs Host Disease - diagnosis</topic><topic>Graft vs Host Disease - drug therapy</topic><topic>Graft vs Host Disease - etiology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Humans</topic><topic>lymphoma</topic><topic>Lymphoma, B-Cell - diagnosis</topic><topic>Lymphoma, B-Cell - therapy</topic><topic>Necrosis</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokime, Kazuya</creatorcontrib><creatorcontrib>Isoda, Ken‐ichi</creatorcontrib><creatorcontrib>Yamanaka, Kei‐ichi</creatorcontrib><creatorcontrib>Mizutani, Hitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokime, Kazuya</au><au>Isoda, Ken‐ichi</au><au>Yamanaka, Kei‐ichi</au><au>Mizutani, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Acute Graft‐versus‐Host Disease Following Autologous Peripheral Blood Stem Cell Transplantation</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2000-07</date><risdate>2000</risdate><volume>27</volume><issue>7</issue><spage>446</spage><epage>449</epage><pages>446-449</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>A 42–year‐old woman developed severe erythema with exfoliative scaling on the bilateral palms and soles and erosive dermatitis on the axillae and groin eight days after an autologous peripheral blood stem cell transplantation for the treatment of non‐Hodgkin's lymphoma. She also developed exanthema; however she did not show intestinal, hepatic, or renal involvement. The skin biopsy revealed characteristic apoptotic cell death of the epidermis with eosinophilic necrosis, and she was diagnosed with acute graft‐versus‐host disease (GVHD). The cutaneous lesions responded to topical corticosteroid treatments and improved within a month without systemic immunosuppressing therapies. The cutaneous GVH reaction did not recur. However, she was treated with an intermittent thrombocyte transfusion because of persistent thrombocytopenia. On day 130, she developed intestinal pneumonia and died due to respiratory dysfunction. Unlike an allo‐bone marrow graft, GVHD after an autologous stem cell transplantation is not common. Even for an autologous transplantation, GVH may develop with less characteristic clinical manifestations.</abstract><cop>England</cop><pmid>10935341</pmid><doi>10.1111/j.1346-8138.2000.tb02203.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of dermatology, 2000-07, Vol.27 (7), p.446-449 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adrenal Cortex Hormones - administration & dosage Adult apoptosis autograft bone marrow transplantation Dermatitis, Exfoliative - drug therapy Dermatitis, Exfoliative - etiology Dermatitis, Exfoliative - pathology Fatal Outcome Female Graft vs Host Disease - diagnosis Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Humans lymphoma Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - therapy Necrosis Transplantation, Autologous |
| title | A Case of Acute Graft‐versus‐Host Disease Following Autologous Peripheral Blood Stem Cell Transplantation |
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