Characterisation of SB-221420-A - a neuronal Ca(2+) and Na(+) channel antagonist in experimental models of stroke

For progression to clinical trials in stroke, putative neuroprotective compounds should show robust efficacy post-ischaemia in several experimental models of stroke. This paper describes the characterisation of (+)(1S, 2R)-cis-1-[4-(1-methyl-1-phenylethyl)phenoxy]-2-methylamino indane hydrochloride...

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Veröffentlicht in:	European journal of pharmacology 2000-08, Vol.401 (3), p.419-428
Hauptverfasser:	Campbell, C A, Barone, F C, Benham, C D, Hadingham, S J, Harries, M H, Harling, J D, Hills, J M, Lewis, V A, Mackay, K B, Orlek, B S, White, R F, Parsons, A A, Hunter, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Animals, Newborn Brain - drug effects Brain - pathology Calcium Channel Blockers - pharmacology Carotid Stenosis - physiopathology Carotid Stenosis - prevention & control Cells, Cultured Consciousness Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Gerbillinae Hemodynamics - drug effects Hypertension - physiopathology Indans - pharmacokinetics Indans - pharmacology Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - prevention & control Ischemic Attack, Transient - physiopathology Ischemic Attack, Transient - prevention & control Male Membrane Potentials - drug effects Metabolic Clearance Rate Mice Motor Activity - drug effects Neurons, Afferent - cytology Neurons, Afferent - drug effects Neurons, Afferent - physiology Neuroprotective Agents - pharmacology Rats Rats, Inbred SHR Rats, Sprague-Dawley Sodium Channel Blockers Stroke - physiopathology Stroke - prevention & control Tissue Distribution
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