A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2004-03, Vol.64 (6), p.1972-1974 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | Xiong, Wei Zeng, Zhao Yang Xia, Jia Hui Xia, Kun Shen, Shou Rong Li, Xiao Ling Hu, Dong Xu Tan, Chen Xiang, Juan Juan Zhou, Jie Deng, Hao Fan, Song Qing Li, Wei Fang Wang, Rong Zhou, Ming Zhu, Shi Guo Lü, Hong Bin Qian, Jun Zhang, Bi Cheng Wang, Jie Ru Ma, Jian Xiao, Bing Yi Huang, He Zhang, Qiu Hong Zhou, Yan Hong Luo, Xiao Min Zhou, Hou De Yang, Yi Xin Dai, He Ping Feng, Guo Yin Pan, Qian Wu, Ling Qian He, Lin Li, Gui Yuan |
| description | Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed. |
| doi_str_mv | 10.1158/0008-5472.CAN-03-3253 |
| format | Article |
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Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.CAN-03-3253</identifier><identifier>PMID: 15026332</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; China - epidemiology ; Chromosome Mapping ; Chromosomes, Human, Pair 3 - genetics ; Female ; Genes, Tumor Suppressor ; Genetic Linkage ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lod Score ; Male ; Medical sciences ; Microsatellite Repeats ; Multigene Family ; Nasopharyngeal Neoplasms - genetics ; Pedigree ; Pharmacology. Drug treatments ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2004-03, Vol.64 (6), p.1972-1974</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-b53a2f00acb4874e9441a2f062079c22cea06dfa3b99a9097511467f523c66743</citedby><cites>FETCH-LOGICAL-c505t-b53a2f00acb4874e9441a2f062079c22cea06dfa3b99a9097511467f523c66743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15574273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15026332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiong, Wei</creatorcontrib><creatorcontrib>Zeng, Zhao Yang</creatorcontrib><creatorcontrib>Xia, Jia Hui</creatorcontrib><creatorcontrib>Xia, Kun</creatorcontrib><creatorcontrib>Shen, Shou Rong</creatorcontrib><creatorcontrib>Li, Xiao Ling</creatorcontrib><creatorcontrib>Hu, Dong Xu</creatorcontrib><creatorcontrib>Tan, Chen</creatorcontrib><creatorcontrib>Xiang, Juan Juan</creatorcontrib><creatorcontrib>Zhou, Jie</creatorcontrib><creatorcontrib>Deng, Hao</creatorcontrib><creatorcontrib>Fan, Song Qing</creatorcontrib><creatorcontrib>Li, Wei Fang</creatorcontrib><creatorcontrib>Wang, Rong</creatorcontrib><creatorcontrib>Zhou, Ming</creatorcontrib><creatorcontrib>Zhu, Shi Guo</creatorcontrib><creatorcontrib>Lü, Hong Bin</creatorcontrib><creatorcontrib>Qian, Jun</creatorcontrib><creatorcontrib>Zhang, Bi Cheng</creatorcontrib><creatorcontrib>Wang, Jie Ru</creatorcontrib><creatorcontrib>Ma, Jian</creatorcontrib><creatorcontrib>Xiao, Bing Yi</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Zhang, Qiu Hong</creatorcontrib><creatorcontrib>Zhou, Yan Hong</creatorcontrib><creatorcontrib>Luo, Xiao Min</creatorcontrib><creatorcontrib>Zhou, Hou De</creatorcontrib><creatorcontrib>Yang, Yi Xin</creatorcontrib><creatorcontrib>Dai, He Ping</creatorcontrib><creatorcontrib>Feng, Guo Yin</creatorcontrib><creatorcontrib>Pan, Qian</creatorcontrib><creatorcontrib>Wu, Ling Qian</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><creatorcontrib>Li, Gui Yuan</creatorcontrib><title>A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>China - epidemiology</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 3 - genetics</subject><subject>Female</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic Linkage</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Multigene Family</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Pedigree</subject><subject>Pharmacology. Drug treatments</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOxDAMRSMEYobHJ4CygV0hLzftcjTiJY1gA-vIzaRMoW1K0y74e1JRATtWlq1jW_cQcsbZFeeQXTPGsgSUFlfr1WPCZCIFyD2y5CCzRCsF-2T5wyzIUQhvsQXO4JAsODCRSimW5GVFwxis64aqqOpq-KS1t2OgOFC7633jg28clZ3gtK7ad7elg6clNpHFmrYYfLfD_rN9dbG12Nuq9Q2ekIMS6-BO53pMXm5vntf3yebp7mG92iQWGAxJARJFyRjaQmVauVwpPg1SwXRuhbAOWbotURZ5jjnLNXCuUl2CkDZNtZLH5PL7btf7j9GFwTRVDFPX2Do_BqO5hjSNUf8Duc5VBlkWQfgGbe9D6F1pur5qYkLDmZnEm0mqmaSaKN4waSbxce98fjAWjdv-bs2mI3AxAxgs1mWPra3CHw60ElrKL5-diqI</recordid><startdate>20040315</startdate><enddate>20040315</enddate><creator>Xiong, Wei</creator><creator>Zeng, Zhao Yang</creator><creator>Xia, Jia Hui</creator><creator>Xia, Kun</creator><creator>Shen, Shou Rong</creator><creator>Li, Xiao Ling</creator><creator>Hu, Dong Xu</creator><creator>Tan, Chen</creator><creator>Xiang, Juan Juan</creator><creator>Zhou, Jie</creator><creator>Deng, Hao</creator><creator>Fan, Song Qing</creator><creator>Li, Wei Fang</creator><creator>Wang, Rong</creator><creator>Zhou, Ming</creator><creator>Zhu, Shi Guo</creator><creator>Lü, Hong Bin</creator><creator>Qian, Jun</creator><creator>Zhang, Bi Cheng</creator><creator>Wang, Jie Ru</creator><creator>Ma, Jian</creator><creator>Xiao, Bing Yi</creator><creator>Huang, He</creator><creator>Zhang, Qiu Hong</creator><creator>Zhou, Yan Hong</creator><creator>Luo, Xiao Min</creator><creator>Zhou, Hou De</creator><creator>Yang, Yi Xin</creator><creator>Dai, He Ping</creator><creator>Feng, Guo Yin</creator><creator>Pan, Qian</creator><creator>Wu, Ling Qian</creator><creator>He, Lin</creator><creator>Li, Gui Yuan</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040315</creationdate><title>A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma</title><author>Xiong, Wei ; Zeng, Zhao Yang ; Xia, Jia Hui ; Xia, Kun ; Shen, Shou Rong ; Li, Xiao Ling ; Hu, Dong Xu ; Tan, Chen ; Xiang, Juan Juan ; Zhou, Jie ; Deng, Hao ; Fan, Song Qing ; Li, Wei Fang ; Wang, Rong ; Zhou, Ming ; Zhu, Shi Guo ; Lü, Hong Bin ; Qian, Jun ; Zhang, Bi Cheng ; Wang, Jie Ru ; Ma, Jian ; Xiao, Bing Yi ; Huang, He ; Zhang, Qiu Hong ; Zhou, Yan Hong ; Luo, Xiao Min ; Zhou, Hou De ; Yang, Yi Xin ; Dai, He Ping ; Feng, Guo Yin ; Pan, Qian ; Wu, Ling Qian ; He, Lin ; Li, Gui Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-b53a2f00acb4874e9441a2f062079c22cea06dfa3b99a9097511467f523c66743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>China - epidemiology</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 3 - genetics</topic><topic>Female</topic><topic>Genes, Tumor Suppressor</topic><topic>Genetic Linkage</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Multigene Family</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Pedigree</topic><topic>Pharmacology. 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Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15026332</pmid><doi>10.1158/0008-5472.CAN-03-3253</doi><tpages>3</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 2004-03, Vol.64 (6), p.1972-1974 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Antineoplastic agents Biological and medical sciences China - epidemiology Chromosome Mapping Chromosomes, Human, Pair 3 - genetics Female Genes, Tumor Suppressor Genetic Linkage Genetic Predisposition to Disease Genotype Humans Lod Score Male Medical sciences Microsatellite Repeats Multigene Family Nasopharyngeal Neoplasms - genetics Pedigree Pharmacology. Drug treatments Tumors |
| title | A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma |
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