Human T Lymphocyte Genetic Modification with Naked DNA

Endowing T lymphocytes with novel functional attributes by genetic modification is under development for a broad range of clinical cellular immunotherapy applications. To circumvent many of the limitations associated with viral vector systems, a plasmid-based electroporation system that reliably gen...

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Veröffentlicht in:	Molecular therapy 2000-01, Vol.1 (1), p.49-55
Hauptverfasser:	Jensen, Michael C., Clarke, Patrick, Tan, Giselle, Wright, Christine, Chung-Chang, Wen, Clark, Teresa N., Zhang, Feiyu, Slovak, Marilyn L., Wu, Anna M., Forman, Stephen J., Raubitschek, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antigens CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Line Cells Clinical trials Clone Cells Cloning Electroporation Genetic Therapy - methods Genetic Vectors Humans Immunotherapy Immunotherapy - methods In Situ Hybridization, Fluorescence Kinases Lymphocytes Membrane Proteins - genetics Membrane Proteins - immunology plasmid vector Plasmids - genetics Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology T cells Vectors (Biology)
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