Hexosamines are unlikely to function as a nutrient-sensor in 3T3-L1 adipocytes: a comparison of UDP-hexosamine levels after increased glucose flux and glucosamine treatment

Whether the hexosamine biosynthesis pathway acts as a nutrient-sensing pathway is still unclear. Glucose is directed into this pathway by GFAT. Because the activity of GFAT is tightly regulated, we examined whether UDP-hexosamine levels can increase significantly and dose-dependently in response to...

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Veröffentlicht in:	Endocrine 2004-02, Vol.23 (1), p.17-24
Hauptverfasser:	Bosch, Remko R, Pouwels, Marie-José J M, Span, Paul N, Olthaar, André J, Tack, Cees J, Hermus, Ad R M M, Sweep, C G J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - metabolism Animals Deoxyglucose - metabolism Glucosamine - pharmacology Glucose - metabolism Hexosamines - metabolism Insulin - metabolism Insulin Resistance - physiology Mice Uridine Diphosphate Glucose - metabolism Uridine Diphosphate N-Acetylgalactosamine - metabolism Uridine Diphosphate N-Acetylglucosamine - metabolism
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