The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells

The transcription factor signal transducer and activator of transcription (Stat) 3 is activated through the interleukin-6 family of cytokines and by binding of growth factors to the epidermal growth factor (EGF) receptor. It plays an essential role in embryonic development and assumes specialized ta...

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Veröffentlicht in:	Molecular cancer research 2004-03, Vol.2 (3), p.170-182
Hauptverfasser:	Nagel-Wolfrum, Kerstin, Buerger, Claudia, Wittig, Ilka, Butz, Karin, Hoppe-Seyler, Felix, Groner, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects bcl-X Protein Caspase 3 Caspases - metabolism Cell Division - drug effects Cell Line, Tumor Dimerization DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Gene Expression Regulation, Neoplastic - drug effects Humans Mice Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Peptide Library Peptides - chemistry Peptides - metabolism Peptides - pharmacology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases Protein Binding Protein Structure, Tertiary Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction - drug effects STAT3 Transcription Factor Trans-Activators - chemistry Trans-Activators - metabolism Transcriptional Activation - drug effects
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