A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver

Recently, a novel inhibitor of inducible nitric oxide synthase, ONO-1714, was developed. We evaluated the effect of ONO-1714 on a critical warm I/R model of the pig liver. Pigs were subjected to 180 min of hepatic warm I/R under the extracorporeal circulation. We investigated the time course of chan...

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Veröffentlicht in:	Transplantation 2002-05, Vol.73 (9), p.1439-1446
Hauptverfasser:	MEGURO, Makoto, KATSURAMAKI, Tadashi, NAGAYAMA, Minoru, KIMURA, Hitoshi, ISOBE, Masato, KIMURA, Yasutoshi, MATSUNO, Takashi, NUI, Akihiro, HIRATA, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - pharmacology Animals Aspartate Aminotransferases - blood Biological and medical sciences Enzyme Inhibitors - pharmacology Female Heterocyclic Compounds, 2-Ring - pharmacology Hot Temperature Ischemia - pathology Ischemia - physiopathology L-Lactate Dehydrogenase - blood Liver - drug effects Liver - metabolism Liver - pathology Liver Circulation - drug effects Liver, biliary tract, pancreas, portal circulation, spleen Medical sciences Nitrates - blood Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Nitrites - blood Reperfusion Injury - pathology Reperfusion Injury - physiopathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival Analysis Swine Thrombosis - prevention & control Tissue Distribution Tyrosine - analogs & derivatives Tyrosine - metabolism
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