Effect of estrogen on exercise electrocardiograms in healthy postmenopausal women
Digoxin has been shown to produce a false-positive exercise electrocardiographic response (ST-segment depression) in about 25% of study subjects.1 Estrogen—which shares certain chemical similarities with digoxin including a steroid nucleus—has been implicated as a cause of a false-positive exercise...
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| Veröffentlicht in: | The American journal of cardiology 2000-08, Vol.86 (4), p.477-479 |
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| creator | Rovang, Karen S Arouni, Amy J Mohiuddin, Syed M Tejani, Aaron Hilleman, Daniel E |
| description | Digoxin has been shown to produce a false-positive exercise electrocardiographic response (ST-segment depression) in about 25% of study subjects.1 Estrogen—which shares certain chemical similarities with digoxin including a steroid nucleus—has been implicated as a cause of a false-positive exercise electrocardiographic response.2 This finding was based on a retrospective study that was not adequately designed to address the causal role of estrogen in producing false-positive stress tests. Age, history of smoking, hypercholesterolemia, diabetes, hypertension, obesity, drug therapy, exercise duration, peak exercise heart rate and blood pressure, concomitant use of progesterone, and prior use of hormone replacement therapy were not predictive of a positive electrocardiographic response. [...]we have demonstrated that approximately 20% of postmenopausal women with a normal baseline stress echocardiogram will have a false-positive exercise electrocardiographic response to oral exogenous estrogen therapy. |
| doi_str_mv | 10.1016/S0002-9149(00)00974-7 |
| format | Article |
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Age, history of smoking, hypercholesterolemia, diabetes, hypertension, obesity, drug therapy, exercise duration, peak exercise heart rate and blood pressure, concomitant use of progesterone, and prior use of hormone replacement therapy were not predictive of a positive electrocardiographic response. [...]we have demonstrated that approximately 20% of postmenopausal women with a normal baseline stress echocardiogram will have a false-positive exercise electrocardiographic response to oral exogenous estrogen therapy.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(00)00974-7</identifier><identifier>PMID: 10946052</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Age ; Aged ; Biological and medical sciences ; Cardiovascular disease ; Chemical fingerprinting ; Chemotherapy ; Coronary vessels ; Diabetes ; Drug Administration Schedule ; Echocardiography ; Electrocardiography ; Electrocardiography - drug effects ; Estrogens ; Estrogens, Conjugated (USP) - administration & dosage ; Estrogens, Conjugated (USP) - pharmacology ; Exercise Test ; False Positive Reactions ; Family medical history ; Female ; Health risk assessment ; Heart rate ; Hormone replacement therapy ; Hormones. Endocrine system ; Humans ; Hypertension ; Medical sciences ; Medroxyprogesterone - administration & dosage ; Medroxyprogesterone - pharmacology ; Menopause ; Middle Aged ; Organic chemistry ; Pharmacology. Drug treatments ; Post-menopause ; Postmenopause - physiology ; Progesterone Congeners - administration & dosage ; Progesterone Congeners - pharmacology ; Steroids ; Ultrasonic imaging ; Women</subject><ispartof>The American journal of cardiology, 2000-08, Vol.86 (4), p.477-479</ispartof><rights>2000 Excerpta Medica Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Age, history of smoking, hypercholesterolemia, diabetes, hypertension, obesity, drug therapy, exercise duration, peak exercise heart rate and blood pressure, concomitant use of progesterone, and prior use of hormone replacement therapy were not predictive of a positive electrocardiographic response. [...]we have demonstrated that approximately 20% of postmenopausal women with a normal baseline stress echocardiogram will have a false-positive exercise electrocardiographic response to oral exogenous estrogen therapy.</description><subject>Administration, Oral</subject><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Chemical fingerprinting</subject><subject>Chemotherapy</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Drug Administration Schedule</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Electrocardiography - drug effects</subject><subject>Estrogens</subject><subject>Estrogens, Conjugated (USP) - administration & dosage</subject><subject>Estrogens, Conjugated (USP) - pharmacology</subject><subject>Exercise Test</subject><subject>False Positive Reactions</subject><subject>Family medical history</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart rate</subject><subject>Hormone replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone - administration & dosage</subject><subject>Medroxyprogesterone - pharmacology</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Organic chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Post-menopause</subject><subject>Postmenopause - physiology</subject><subject>Progesterone Congeners - administration & dosage</subject><subject>Progesterone Congeners - pharmacology</subject><subject>Steroids</subject><subject>Ultrasonic imaging</subject><subject>Women</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkVFrFTEQhYNY7LX6E5SgIvVhdWY32b15Eim1FQoi6nPIJpM2ZXdzm-yq_ffm9l5UBPEpGeabw-Ecxp4gvEbA9s1nAKgrhUIdA7wCUJ2ountshetOVaiwuc9Wv5BD9jDn6zIiyvYBO0RQogVZr9inU-_Jzjx6TnlO8ZImHidOPyjZkInTULYpWpNciJfJjJmHiV-RGearW76JeR5pihuzZDPw77EMj9iBN0Omx_v3iH19f_rl5Ly6-Hj24eTdRWWFkHPlQWLXul4qb6ysWwIjpOu9gbamNSipwNG6R9E766yU5Q8GyAsrPEItmiP2cqe7SfFmKeb1GLKlYTATxSXrDjvZCLUFn_0FXsclTcWbrhtoZKdQFuj5PyEQrRQS262U3FE2xZwTeb1JYTTpViPobS36rha9zVwD6LtadFfunu7Vl34k98fVrocCvNgDJlsz-GSmEv9vTnRYyivY2x1GJdhvgZLONtBkyYVUetIuhv84-Qm_dajM</recordid><startdate>20000815</startdate><enddate>20000815</enddate><creator>Rovang, Karen S</creator><creator>Arouni, Amy J</creator><creator>Mohiuddin, Syed M</creator><creator>Tejani, Aaron</creator><creator>Hilleman, Daniel E</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000815</creationdate><title>Effect of estrogen on exercise electrocardiograms in healthy postmenopausal women</title><author>Rovang, Karen S ; Arouni, Amy J ; Mohiuddin, Syed M ; Tejani, Aaron ; Hilleman, Daniel E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-f05176db59fac526e0a45dbfa062e809590de8b14bdcdc55e8b0a0ef4c4f10243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Oral</topic><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Chemical fingerprinting</topic><topic>Chemotherapy</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Drug Administration Schedule</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Electrocardiography - drug effects</topic><topic>Estrogens</topic><topic>Estrogens, Conjugated (USP) - administration & dosage</topic><topic>Estrogens, Conjugated (USP) - pharmacology</topic><topic>Exercise Test</topic><topic>False Positive Reactions</topic><topic>Family medical history</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Heart rate</topic><topic>Hormone replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone - administration & dosage</topic><topic>Medroxyprogesterone - pharmacology</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Organic chemistry</topic><topic>Pharmacology. 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Age, history of smoking, hypercholesterolemia, diabetes, hypertension, obesity, drug therapy, exercise duration, peak exercise heart rate and blood pressure, concomitant use of progesterone, and prior use of hormone replacement therapy were not predictive of a positive electrocardiographic response. [...]we have demonstrated that approximately 20% of postmenopausal women with a normal baseline stress echocardiogram will have a false-positive exercise electrocardiographic response to oral exogenous estrogen therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10946052</pmid><doi>10.1016/S0002-9149(00)00974-7</doi><tpages>3</tpages></addata></record> |
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| subjects | Administration, Oral Age Aged Biological and medical sciences Cardiovascular disease Chemical fingerprinting Chemotherapy Coronary vessels Diabetes Drug Administration Schedule Echocardiography Electrocardiography Electrocardiography - drug effects Estrogens Estrogens, Conjugated (USP) - administration & dosage Estrogens, Conjugated (USP) - pharmacology Exercise Test False Positive Reactions Family medical history Female Health risk assessment Heart rate Hormone replacement therapy Hormones. Endocrine system Humans Hypertension Medical sciences Medroxyprogesterone - administration & dosage Medroxyprogesterone - pharmacology Menopause Middle Aged Organic chemistry Pharmacology. Drug treatments Post-menopause Postmenopause - physiology Progesterone Congeners - administration & dosage Progesterone Congeners - pharmacology Steroids Ultrasonic imaging Women |
| title | Effect of estrogen on exercise electrocardiograms in healthy postmenopausal women |
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