Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption
Objective: To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption. Design: A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia. Setting: A university...
Gespeichert in:
| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2004-03, Vol.113 (1), p.31-35 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 35 |
|---|---|
| container_issue | 1 |
| container_start_page | 31 |
| container_title | European journal of obstetrics & gynecology and reproductive biology |
| container_volume | 113 |
| creator | Anteby, Eyal Y. Musalam, Banan Milwidsky, Ariel Blumenfeld, Anat Gilis, Shmuel Valsky, Dan Hamani, Yaron |
| description | Objective: To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.
Design: A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.
Setting: A university hospital with 3700 deliveries per year.
Population: Seventy cases with severe preeclampsia, IUGR or placental abruption.
Methods: Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.
Main outcome measures: Gestational age at delivery, birth weight and early neonatal complications.
Results: Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.
Conclusions: Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity. |
| doi_str_mv | 10.1016/j.ejogrb.2003.05.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71753341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301211503004287</els_id><sourcerecordid>71753341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-f5054ae97b18e4f964efd256b428ac977513fdd2aa102054acbda70467867e723</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVpabZp_0EpvrSn2tWn5b0USmjSQKBQmrMYS6OuFtlyJTuQf1-bXWhOmcsc5nlfhoeQ94w2jLL2y7HBY_qT-4ZTKhqqGkr5C7Jjnea1bpV8SXZUUFZzxtQFeVPKka4jxP41uWCKilZTvSP2GmeIVRgPmMOMrpoPOQ19mg4hBijrwccFR4vrAauCDxv2WCVfTRnRRhimEuBzdXt_86uC0VVTBIvj1gl9XqY5pPEteeUhFnx33pfk_vr776sf9d3Pm9urb3e1FV03115RJQH3umcdSr9vJXrHVdtL3oHda62Y8M5xAEb5htregaay1V2rUXNxST6deqec_i5YZjOEYjFGGDEtxWimlRCSraA8gTanUjJ6M-UwQH40jJpNrjmak1yzyTVUmVXuGvtw7l_6Ad3_0NnmCnw8A1AsRJ9htKE84ZSUSmxFX08crjYeAmZTbNgku5DRzsal8Pwn_wBvWJp5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71753341</pqid></control><display><type>article</type><title>Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Anteby, Eyal Y. ; Musalam, Banan ; Milwidsky, Ariel ; Blumenfeld, Anat ; Gilis, Shmuel ; Valsky, Dan ; Hamani, Yaron</creator><creatorcontrib>Anteby, Eyal Y. ; Musalam, Banan ; Milwidsky, Ariel ; Blumenfeld, Anat ; Gilis, Shmuel ; Valsky, Dan ; Hamani, Yaron</creatorcontrib><description>Objective: To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.
Design: A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.
Setting: A university hospital with 3700 deliveries per year.
Population: Seventy cases with severe preeclampsia, IUGR or placental abruption.
Methods: Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.
Main outcome measures: Gestational age at delivery, birth weight and early neonatal complications.
Results: Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.
Conclusions: Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2003.05.002</identifier><identifier>PMID: 15036707</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Abruptio Placentae - genetics ; Adult ; Biological and medical sciences ; Case-Control Studies ; Diseases of mother, fetus and pregnancy ; Factor V - genetics ; Female ; Fetal Diseases - genetics ; Fetal Growth Retardation - genetics ; Gynecology. Andrology. Obstetrics ; Hematologic and hematopoietic diseases ; Humans ; Intrauterine growth restriction ; Medical sciences ; Placental abruption ; Platelet diseases and coagulopathies ; Pre-Eclampsia - genetics ; Preeclampsia ; Pregnancy ; Pregnancy Complications ; Pregnancy. Fetus. Placenta ; Severity of Illness Index ; Thrombophilia ; Thrombophilia - genetics</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2004-03, Vol.113 (1), p.31-35</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-f5054ae97b18e4f964efd256b428ac977513fdd2aa102054acbda70467867e723</citedby><cites>FETCH-LOGICAL-c388t-f5054ae97b18e4f964efd256b428ac977513fdd2aa102054acbda70467867e723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211503004287$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15544532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15036707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anteby, Eyal Y.</creatorcontrib><creatorcontrib>Musalam, Banan</creatorcontrib><creatorcontrib>Milwidsky, Ariel</creatorcontrib><creatorcontrib>Blumenfeld, Anat</creatorcontrib><creatorcontrib>Gilis, Shmuel</creatorcontrib><creatorcontrib>Valsky, Dan</creatorcontrib><creatorcontrib>Hamani, Yaron</creatorcontrib><title>Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Objective: To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.
Design: A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.
Setting: A university hospital with 3700 deliveries per year.
Population: Seventy cases with severe preeclampsia, IUGR or placental abruption.
Methods: Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.
Main outcome measures: Gestational age at delivery, birth weight and early neonatal complications.
Results: Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.
Conclusions: Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity.</description><subject>Abruptio Placentae - genetics</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Fetal Diseases - genetics</subject><subject>Fetal Growth Retardation - genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Intrauterine growth restriction</subject><subject>Medical sciences</subject><subject>Placental abruption</subject><subject>Platelet diseases and coagulopathies</subject><subject>Pre-Eclampsia - genetics</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Severity of Illness Index</subject><subject>Thrombophilia</subject><subject>Thrombophilia - genetics</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpabZp_0EpvrSn2tWn5b0USmjSQKBQmrMYS6OuFtlyJTuQf1-bXWhOmcsc5nlfhoeQ94w2jLL2y7HBY_qT-4ZTKhqqGkr5C7Jjnea1bpV8SXZUUFZzxtQFeVPKka4jxP41uWCKilZTvSP2GmeIVRgPmMOMrpoPOQ19mg4hBijrwccFR4vrAauCDxv2WCVfTRnRRhimEuBzdXt_86uC0VVTBIvj1gl9XqY5pPEteeUhFnx33pfk_vr776sf9d3Pm9urb3e1FV03115RJQH3umcdSr9vJXrHVdtL3oHda62Y8M5xAEb5htregaay1V2rUXNxST6deqec_i5YZjOEYjFGGDEtxWimlRCSraA8gTanUjJ6M-UwQH40jJpNrjmak1yzyTVUmVXuGvtw7l_6Ad3_0NnmCnw8A1AsRJ9htKE84ZSUSmxFX08crjYeAmZTbNgku5DRzsal8Pwn_wBvWJp5</recordid><startdate>20040315</startdate><enddate>20040315</enddate><creator>Anteby, Eyal Y.</creator><creator>Musalam, Banan</creator><creator>Milwidsky, Ariel</creator><creator>Blumenfeld, Anat</creator><creator>Gilis, Shmuel</creator><creator>Valsky, Dan</creator><creator>Hamani, Yaron</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040315</creationdate><title>Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption</title><author>Anteby, Eyal Y. ; Musalam, Banan ; Milwidsky, Ariel ; Blumenfeld, Anat ; Gilis, Shmuel ; Valsky, Dan ; Hamani, Yaron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-f5054ae97b18e4f964efd256b428ac977513fdd2aa102054acbda70467867e723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abruptio Placentae - genetics</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Fetal Diseases - genetics</topic><topic>Fetal Growth Retardation - genetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Intrauterine growth restriction</topic><topic>Medical sciences</topic><topic>Placental abruption</topic><topic>Platelet diseases and coagulopathies</topic><topic>Pre-Eclampsia - genetics</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Severity of Illness Index</topic><topic>Thrombophilia</topic><topic>Thrombophilia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anteby, Eyal Y.</creatorcontrib><creatorcontrib>Musalam, Banan</creatorcontrib><creatorcontrib>Milwidsky, Ariel</creatorcontrib><creatorcontrib>Blumenfeld, Anat</creatorcontrib><creatorcontrib>Gilis, Shmuel</creatorcontrib><creatorcontrib>Valsky, Dan</creatorcontrib><creatorcontrib>Hamani, Yaron</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anteby, Eyal Y.</au><au>Musalam, Banan</au><au>Milwidsky, Ariel</au><au>Blumenfeld, Anat</au><au>Gilis, Shmuel</au><au>Valsky, Dan</au><au>Hamani, Yaron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2004-03-15</date><risdate>2004</risdate><volume>113</volume><issue>1</issue><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Objective: To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.
Design: A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.
Setting: A university hospital with 3700 deliveries per year.
Population: Seventy cases with severe preeclampsia, IUGR or placental abruption.
Methods: Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.
Main outcome measures: Gestational age at delivery, birth weight and early neonatal complications.
Results: Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.
Conclusions: Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15036707</pmid><doi>10.1016/j.ejogrb.2003.05.002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-2115 |
| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2004-03, Vol.113 (1), p.31-35 |
| issn | 0301-2115 1872-7654 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71753341 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abruptio Placentae - genetics Adult Biological and medical sciences Case-Control Studies Diseases of mother, fetus and pregnancy Factor V - genetics Female Fetal Diseases - genetics Fetal Growth Retardation - genetics Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases Humans Intrauterine growth restriction Medical sciences Placental abruption Platelet diseases and coagulopathies Pre-Eclampsia - genetics Preeclampsia Pregnancy Pregnancy Complications Pregnancy. Fetus. Placenta Severity of Illness Index Thrombophilia Thrombophilia - genetics |
| title | Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T19%3A06%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fetal%20inherited%20thrombophilias%20influence%20the%20severity%20of%20preeclampsia,%20IUGR%20and%20placental%20abruption&rft.jtitle=European%20journal%20of%20obstetrics%20&%20gynecology%20and%20reproductive%20biology&rft.au=Anteby,%20Eyal%20Y.&rft.date=2004-03-15&rft.volume=113&rft.issue=1&rft.spage=31&rft.epage=35&rft.pages=31-35&rft.issn=0301-2115&rft.eissn=1872-7654&rft.coden=EOGRAL&rft_id=info:doi/10.1016/j.ejogrb.2003.05.002&rft_dat=%3Cproquest_cross%3E71753341%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71753341&rft_id=info:pmid/15036707&rft_els_id=S0301211503004287&rfr_iscdi=true |