Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non–q-wave acute myocardial infarction
Inflammation and chronic infections may be important features in the pathogenesis of acute coronary syndromes. We describe 6 systemic markers of inflammation in patients with unstable angina or non–Q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infect...
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| Veröffentlicht in: | The American journal of cardiology 2000-08, Vol.86 (4), p.379-384 |
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| creator | Choussat, Rémi Montalescot, Gilles Collet, Jean-Philippe Jardel, Claude Ankri, Annick Fillet, Anne-Marie Thomas, Danielle Raymond, Josette Bastard, Jean-Philippe Drobinski, Gérard Orfila, Jeanne Agut, Henri Thomas, Daniel |
| description | Inflammation and chronic infections may be important features in the pathogenesis of acute coronary syndromes. We describe 6 systemic markers of inflammation in patients with unstable angina or non–Q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infections, and prognosis. C-reactive protein (CRP), serum amyloid A protein (SAA), fibrinogen, interleukin-6 (IL-6), neopterin, procalcitonin, and serum antibody levels to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus were measured on admission and 48 hours later. One-year clinical follow-up was performed. Plasma levels of acute phase reactants were all elevated on admission and increased further at 48 hours: CRP from 10.1 ± 2.1 mg/L at baseline to 26.6 ± 5.1 mg/L at 48 hours (p |
| doi_str_mv | 10.1016/S0002-9149(00)00950-4 |
| format | Article |
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We describe 6 systemic markers of inflammation in patients with unstable angina or non–Q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infections, and prognosis. C-reactive protein (CRP), serum amyloid A protein (SAA), fibrinogen, interleukin-6 (IL-6), neopterin, procalcitonin, and serum antibody levels to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus were measured on admission and 48 hours later. One-year clinical follow-up was performed. Plasma levels of acute phase reactants were all elevated on admission and increased further at 48 hours: CRP from 10.1 ± 2.1 mg/L at baseline to 26.6 ± 5.1 mg/L at 48 hours (p <0.001); SAA from 27.3 ± 8.5 to 93.1 ± 23.2 mg/dl (p <0.005); fibrinogen from 3.2 ± 0.1 to 3.8 ± 0.1 g/L (p <0.0001); whereas initial high levels of IL-6 tended also to increase from 9.8 ± 2 to 15.3 ± 3.1 pg/ml (p = NS). In contrast, neopterin and procalcitonin remained unchanged. We found no association between levels of each inflammatory marker and the serologic status. Furthermore, levels of inflammatory proteins in patients seronegative to all 3 agents were comparable to those of patients seropositive to 2 or 3 infectious agents. The composite end points of death, myocardial infarction, recurrent angina, or revascularization at 1-year follow-up did not differ according to the serologic status. Thus, in patients with acute coronary syndromes, the acute phase proteins increased over the first 2 days of hospitalization. This initial inflammatory reaction as well as the 1-year clinical outcome did not differ according to the initial serologic status of Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(00)00950-4</identifier><identifier>PMID: 10946028</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute phase proteins ; Acute-Phase Proteins - metabolism ; Aged ; Amyloid ; Angina ; Angina pectoris ; Angina, Unstable - blood ; Angina, Unstable - etiology ; Angioplasty ; Bacterial infections ; Biological and medical sciences ; Biomarkers - blood ; C-reactive protein ; Cardiology. Vascular system ; Cardiovascular disease ; Chlamydia ; Chlamydia Infections - blood ; Chlamydia Infections - complications ; Chlamydia pneumoniae ; Chlamydophila pneumoniae ; Coronary heart disease ; Coronary vessels ; Cytomegalovirus ; Cytomegalovirus Infections - blood ; Cytomegalovirus Infections - complications ; Disorders ; Electrocardiography ; Enzymes ; Family medical history ; Female ; Fibrinogen ; Health risk assessment ; Heart ; Heart attacks ; Heart rate ; Helicobacter Infections - blood ; Helicobacter Infections - complications ; Helicobacter pylori ; Hemodynamics ; Humans ; Immunoglobulins ; Infection - complications ; Infections ; Inflammation ; Inflammation - blood ; Interleukin 6 ; Interleukins ; Linear Models ; Male ; Markers ; Medical prognosis ; Medical sciences ; Multivariate analysis ; Myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - etiology ; Neopterin ; Pain ; Pathogenesis ; Patients ; Plasma levels ; Procalcitonin ; Prognosis ; Prospective Studies ; Proteins ; Sexually transmitted diseases ; STD ; Viral infections</subject><ispartof>The American journal of cardiology, 2000-08, Vol.86 (4), p.379-384</ispartof><rights>2000 Excerpta Medica Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Aug 15, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-e33333de97881a10ec0c8f00143a46b60ff63d421ae805f431438f743e5fad1b3</citedby><cites>FETCH-LOGICAL-c418t-e33333de97881a10ec0c8f00143a46b60ff63d421ae805f431438f743e5fad1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9149(00)00950-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1470420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10946028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choussat, Rémi</creatorcontrib><creatorcontrib>Montalescot, Gilles</creatorcontrib><creatorcontrib>Collet, Jean-Philippe</creatorcontrib><creatorcontrib>Jardel, Claude</creatorcontrib><creatorcontrib>Ankri, Annick</creatorcontrib><creatorcontrib>Fillet, Anne-Marie</creatorcontrib><creatorcontrib>Thomas, Danielle</creatorcontrib><creatorcontrib>Raymond, Josette</creatorcontrib><creatorcontrib>Bastard, Jean-Philippe</creatorcontrib><creatorcontrib>Drobinski, Gérard</creatorcontrib><creatorcontrib>Orfila, Jeanne</creatorcontrib><creatorcontrib>Agut, Henri</creatorcontrib><creatorcontrib>Thomas, Daniel</creatorcontrib><title>Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non–q-wave acute myocardial infarction</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Inflammation and chronic infections may be important features in the pathogenesis of acute coronary syndromes. We describe 6 systemic markers of inflammation in patients with unstable angina or non–Q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infections, and prognosis. C-reactive protein (CRP), serum amyloid A protein (SAA), fibrinogen, interleukin-6 (IL-6), neopterin, procalcitonin, and serum antibody levels to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus were measured on admission and 48 hours later. One-year clinical follow-up was performed. Plasma levels of acute phase reactants were all elevated on admission and increased further at 48 hours: CRP from 10.1 ± 2.1 mg/L at baseline to 26.6 ± 5.1 mg/L at 48 hours (p <0.001); SAA from 27.3 ± 8.5 to 93.1 ± 23.2 mg/dl (p <0.005); fibrinogen from 3.2 ± 0.1 to 3.8 ± 0.1 g/L (p <0.0001); whereas initial high levels of IL-6 tended also to increase from 9.8 ± 2 to 15.3 ± 3.1 pg/ml (p = NS). In contrast, neopterin and procalcitonin remained unchanged. We found no association between levels of each inflammatory marker and the serologic status. Furthermore, levels of inflammatory proteins in patients seronegative to all 3 agents were comparable to those of patients seropositive to 2 or 3 infectious agents. The composite end points of death, myocardial infarction, recurrent angina, or revascularization at 1-year follow-up did not differ according to the serologic status. Thus, in patients with acute coronary syndromes, the acute phase proteins increased over the first 2 days of hospitalization. This initial inflammatory reaction as well as the 1-year clinical outcome did not differ according to the initial serologic status of Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus.</description><subject>Acute phase proteins</subject><subject>Acute-Phase Proteins - metabolism</subject><subject>Aged</subject><subject>Amyloid</subject><subject>Angina</subject><subject>Angina pectoris</subject><subject>Angina, Unstable - blood</subject><subject>Angina, Unstable - etiology</subject><subject>Angioplasty</subject><subject>Bacterial infections</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - blood</subject><subject>Chlamydia Infections - complications</subject><subject>Chlamydia pneumoniae</subject><subject>Chlamydophila pneumoniae</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - blood</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Disorders</subject><subject>Electrocardiography</subject><subject>Enzymes</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart rate</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infection - complications</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Linear Models</subject><subject>Male</subject><subject>Markers</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Multivariate analysis</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - etiology</subject><subject>Neopterin</subject><subject>Pain</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Plasma levels</subject><subject>Procalcitonin</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Viral infections</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks-KFDEQxhtR3HX1EZSAIgrbWplO_zuJDKsrLHhQzyGTrsxk6U5mk_SsffMdfEPxQayeGVS8mEsT6lf1fZ2vsuwxh1ccePX6EwAs8paL9gXAS4C2hFzcyU55U7c5b3lxNzv9jZxkD2K8pivnZXU_O-HQigoWzWn288IY1Il5w7bB-sDw69bHMSBLni03vRqmziq2dTgO3lmF5-wSe6v9SumEgW2n3gd7zqhTT8kPuFa939kwRuYdSxtkHa4D4ixgnaF5g0qWSsp1RGA-oaIpwa-djzbufRCALkV2a9OGjS4mteqRGtbWkRNyS4pxVnTe_fj2_Sa_VTuq6zEhGyavVSDL_Syngp7FHmb3jOojPjp-z7Iv7y4-Ly_zq4_vPyzfXuVa8CblWMynw7ZuGq44oAbdGHo0UShRrSowpio6seAKGyiNKKjQmFoUWBrV8VVxlj0_zKX_uRkxJjnYqLHvlUM_RlnzuiwWoibw6T_gtR-DI29yAaIqRQlVSVR5oHTwMQY0kiIaVJgkBzkvgdwvgZwTlgByvwRSUN-T4_RxNWD3V9chdQKeHQEVtepNUE7b-IcTNYgFEPbmgCG92c5ikFFTMho7GygF2Xn7Hye_AP1E1B0</recordid><startdate>20000815</startdate><enddate>20000815</enddate><creator>Choussat, Rémi</creator><creator>Montalescot, Gilles</creator><creator>Collet, Jean-Philippe</creator><creator>Jardel, Claude</creator><creator>Ankri, Annick</creator><creator>Fillet, Anne-Marie</creator><creator>Thomas, Danielle</creator><creator>Raymond, Josette</creator><creator>Bastard, Jean-Philippe</creator><creator>Drobinski, Gérard</creator><creator>Orfila, Jeanne</creator><creator>Agut, Henri</creator><creator>Thomas, Daniel</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000815</creationdate><title>Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non–q-wave acute myocardial infarction</title><author>Choussat, Rémi ; Montalescot, Gilles ; Collet, Jean-Philippe ; Jardel, Claude ; Ankri, Annick ; Fillet, Anne-Marie ; Thomas, Danielle ; Raymond, Josette ; Bastard, Jean-Philippe ; Drobinski, Gérard ; Orfila, Jeanne ; Agut, Henri ; Thomas, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e33333de97881a10ec0c8f00143a46b60ff63d421ae805f431438f743e5fad1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acute phase proteins</topic><topic>Acute-Phase Proteins - metabolism</topic><topic>Aged</topic><topic>Amyloid</topic><topic>Angina</topic><topic>Angina pectoris</topic><topic>Angina, Unstable - blood</topic><topic>Angina, Unstable - etiology</topic><topic>Angioplasty</topic><topic>Bacterial infections</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Chlamydia</topic><topic>Chlamydia Infections - blood</topic><topic>Chlamydia Infections - complications</topic><topic>Chlamydia pneumoniae</topic><topic>Chlamydophila pneumoniae</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - blood</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Disorders</topic><topic>Electrocardiography</topic><topic>Enzymes</topic><topic>Family medical history</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart rate</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infection - complications</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Linear Models</topic><topic>Male</topic><topic>Markers</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Multivariate analysis</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - etiology</topic><topic>Neopterin</topic><topic>Pain</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Plasma levels</topic><topic>Procalcitonin</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choussat, Rémi</creatorcontrib><creatorcontrib>Montalescot, Gilles</creatorcontrib><creatorcontrib>Collet, Jean-Philippe</creatorcontrib><creatorcontrib>Jardel, Claude</creatorcontrib><creatorcontrib>Ankri, Annick</creatorcontrib><creatorcontrib>Fillet, Anne-Marie</creatorcontrib><creatorcontrib>Thomas, Danielle</creatorcontrib><creatorcontrib>Raymond, Josette</creatorcontrib><creatorcontrib>Bastard, Jean-Philippe</creatorcontrib><creatorcontrib>Drobinski, Gérard</creatorcontrib><creatorcontrib>Orfila, Jeanne</creatorcontrib><creatorcontrib>Agut, Henri</creatorcontrib><creatorcontrib>Thomas, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choussat, Rémi</au><au>Montalescot, Gilles</au><au>Collet, Jean-Philippe</au><au>Jardel, Claude</au><au>Ankri, Annick</au><au>Fillet, Anne-Marie</au><au>Thomas, Danielle</au><au>Raymond, Josette</au><au>Bastard, Jean-Philippe</au><au>Drobinski, Gérard</au><au>Orfila, Jeanne</au><au>Agut, Henri</au><au>Thomas, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non–q-wave acute myocardial infarction</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2000-08-15</date><risdate>2000</risdate><volume>86</volume><issue>4</issue><spage>379</spage><epage>384</epage><pages>379-384</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Inflammation and chronic infections may be important features in the pathogenesis of acute coronary syndromes. We describe 6 systemic markers of inflammation in patients with unstable angina or non–Q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infections, and prognosis. C-reactive protein (CRP), serum amyloid A protein (SAA), fibrinogen, interleukin-6 (IL-6), neopterin, procalcitonin, and serum antibody levels to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus were measured on admission and 48 hours later. One-year clinical follow-up was performed. Plasma levels of acute phase reactants were all elevated on admission and increased further at 48 hours: CRP from 10.1 ± 2.1 mg/L at baseline to 26.6 ± 5.1 mg/L at 48 hours (p <0.001); SAA from 27.3 ± 8.5 to 93.1 ± 23.2 mg/dl (p <0.005); fibrinogen from 3.2 ± 0.1 to 3.8 ± 0.1 g/L (p <0.0001); whereas initial high levels of IL-6 tended also to increase from 9.8 ± 2 to 15.3 ± 3.1 pg/ml (p = NS). In contrast, neopterin and procalcitonin remained unchanged. We found no association between levels of each inflammatory marker and the serologic status. Furthermore, levels of inflammatory proteins in patients seronegative to all 3 agents were comparable to those of patients seropositive to 2 or 3 infectious agents. The composite end points of death, myocardial infarction, recurrent angina, or revascularization at 1-year follow-up did not differ according to the serologic status. Thus, in patients with acute coronary syndromes, the acute phase proteins increased over the first 2 days of hospitalization. This initial inflammatory reaction as well as the 1-year clinical outcome did not differ according to the initial serologic status of Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10946028</pmid><doi>10.1016/S0002-9149(00)00950-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 2000-08, Vol.86 (4), p.379-384 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acute phase proteins Acute-Phase Proteins - metabolism Aged Amyloid Angina Angina pectoris Angina, Unstable - blood Angina, Unstable - etiology Angioplasty Bacterial infections Biological and medical sciences Biomarkers - blood C-reactive protein Cardiology. Vascular system Cardiovascular disease Chlamydia Chlamydia Infections - blood Chlamydia Infections - complications Chlamydia pneumoniae Chlamydophila pneumoniae Coronary heart disease Coronary vessels Cytomegalovirus Cytomegalovirus Infections - blood Cytomegalovirus Infections - complications Disorders Electrocardiography Enzymes Family medical history Female Fibrinogen Health risk assessment Heart Heart attacks Heart rate Helicobacter Infections - blood Helicobacter Infections - complications Helicobacter pylori Hemodynamics Humans Immunoglobulins Infection - complications Infections Inflammation Inflammation - blood Interleukin 6 Interleukins Linear Models Male Markers Medical prognosis Medical sciences Multivariate analysis Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - etiology Neopterin Pain Pathogenesis Patients Plasma levels Procalcitonin Prognosis Prospective Studies Proteins Sexually transmitted diseases STD Viral infections |
| title | Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non–q-wave acute myocardial infarction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T05%3A13%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20prior%20exposure%20to%20Chlamydia%20pneumoniae,%20Helicobacter%20pylori,%20or%20cytomegalovirus%20on%20the%20degree%20of%20inflammation%20and%20one-year%20prognosis%20of%20patients%20with%20unstable%20angina%20pectoris%20or%20non%E2%80%93q-wave%20acute%20myocardial%20infarction&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Choussat,%20R%C3%A9mi&rft.date=2000-08-15&rft.volume=86&rft.issue=4&rft.spage=379&rft.epage=384&rft.pages=379-384&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/S0002-9149(00)00950-4&rft_dat=%3Cproquest_cross%3E71753247%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2046545065&rft_id=info:pmid/10946028&rft_els_id=S0002914900009504&rfr_iscdi=true |