How protozoan parasites evade the immune response
Protozoan pathogens such as Plasmodium, Leishmania, Trypanosoma and Entamoeba are responsible for several of the most widespread and lethal human diseases. Their successful survival depends mainly on evading the host immune system by, for example, penetrating and multiplying within cells, varying th...
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| Veröffentlicht in: | Trends in Parasitology 2002-06, Vol.18 (6), p.272-278 |
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| creator | Zambrano-Villa, Sergio Rosales-Borjas, Disney Carrero, Julio César Ortiz-Ortiz, Librado |
| description | Protozoan pathogens such as
Plasmodium,
Leishmania,
Trypanosoma and
Entamoeba are responsible for several of the most widespread and lethal human diseases. Their successful survival depends mainly on evading the host immune system by, for example, penetrating and multiplying within cells, varying their surface antigens, eliminating their protein coat, and modulating the host immune response. Immunosuppression is sometimes caused directly by parasite products and sometimes involves antigenic mimicry, which often appears in association with parasitic diseases. However, one of the most sophisticated mechanisms of evasion is the selective activation of a subset of T helper cells.
The present review describes mechanisms used by some protozoa pathogenic to humans to evade the host immune response. Relatively complex mechanisms by which protozoa penetrate, multiply within the cells and survive are discussed. |
| doi_str_mv | 10.1016/S1471-4922(02)02289-4 |
| format | Article |
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Plasmodium,
Leishmania,
Trypanosoma and
Entamoeba are responsible for several of the most widespread and lethal human diseases. Their successful survival depends mainly on evading the host immune system by, for example, penetrating and multiplying within cells, varying their surface antigens, eliminating their protein coat, and modulating the host immune response. Immunosuppression is sometimes caused directly by parasite products and sometimes involves antigenic mimicry, which often appears in association with parasitic diseases. However, one of the most sophisticated mechanisms of evasion is the selective activation of a subset of T helper cells.
The present review describes mechanisms used by some protozoa pathogenic to humans to evade the host immune response. Relatively complex mechanisms by which protozoa penetrate, multiply within the cells and survive are discussed.</description><identifier>ISSN: 1471-4922</identifier><identifier>EISSN: 1471-5007</identifier><identifier>DOI: 10.1016/S1471-4922(02)02289-4</identifier><identifier>PMID: 12036742</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amebiasis - immunology ; Animals ; Antigenic Variation ; Biological and medical sciences ; CD4 ; CD8 I ; Chagas Disease - immunology ; cytokines ; Entamoeba histolytica - immunology ; evasion ; Fundamental and applied biological sciences. Psychology ; Humans ; immune response ; immunosuppression ; Leishmania - immunology ; Leishmaniasis - immunology ; Life cycle. Host-agent relationship. Pathogenesis ; Malaria - immunology ; Plasmodium - immunology ; Protozoa ; Protozoan Infections - immunology ; T helper (Th) cells ; Trypanosoma - immunology ; Trypanosomiasis, African - immunology</subject><ispartof>Trends in Parasitology, 2002-06, Vol.18 (6), p.272-278</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-828a5abbb8079296a9a4172f80d156143002e7546d1f9cac2b761399b56967cb3</citedby><cites>FETCH-LOGICAL-c443t-828a5abbb8079296a9a4172f80d156143002e7546d1f9cac2b761399b56967cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1471-4922(02)02289-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3550,27922,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14186472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12036742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zambrano-Villa, Sergio</creatorcontrib><creatorcontrib>Rosales-Borjas, Disney</creatorcontrib><creatorcontrib>Carrero, Julio César</creatorcontrib><creatorcontrib>Ortiz-Ortiz, Librado</creatorcontrib><title>How protozoan parasites evade the immune response</title><title>Trends in Parasitology</title><addtitle>Trends Parasitol</addtitle><description>Protozoan pathogens such as
Plasmodium,
Leishmania,
Trypanosoma and
Entamoeba are responsible for several of the most widespread and lethal human diseases. Their successful survival depends mainly on evading the host immune system by, for example, penetrating and multiplying within cells, varying their surface antigens, eliminating their protein coat, and modulating the host immune response. Immunosuppression is sometimes caused directly by parasite products and sometimes involves antigenic mimicry, which often appears in association with parasitic diseases. However, one of the most sophisticated mechanisms of evasion is the selective activation of a subset of T helper cells.
The present review describes mechanisms used by some protozoa pathogenic to humans to evade the host immune response. Relatively complex mechanisms by which protozoa penetrate, multiply within the cells and survive are discussed.</description><subject>Amebiasis - immunology</subject><subject>Animals</subject><subject>Antigenic Variation</subject><subject>Biological and medical sciences</subject><subject>CD4</subject><subject>CD8 I</subject><subject>Chagas Disease - immunology</subject><subject>cytokines</subject><subject>Entamoeba histolytica - immunology</subject><subject>evasion</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>immune response</subject><subject>immunosuppression</subject><subject>Leishmania - immunology</subject><subject>Leishmaniasis - immunology</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Malaria - immunology</subject><subject>Plasmodium - immunology</subject><subject>Protozoa</subject><subject>Protozoan Infections - immunology</subject><subject>T helper (Th) cells</subject><subject>Trypanosoma - immunology</subject><subject>Trypanosomiasis, African - immunology</subject><issn>1471-4922</issn><issn>1471-5007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7rr6E5ReFD1UkzSP5iSy-IIFD-o5pOkUI32ZtCv66213C3sUBmYYvnnwIXRK8DXBRNy8EiZJzBSll5heYUpTFbM9NN-0OcZyf6pHZIaOQvjEmHAp1SGaEYoTIRmdI_LUfEetb7rmtzF11BpvgusgRLA2OUTdB0SuqvoaIg-hbeoAx-igMGWAkykv0PvD_dvyKV69PD4v71axZSzp4pSmhpssy1IsFVXCKMOIpEWKc8IFYQnGFCRnIieFssbSTAqSKJVxoYS0WbJAF9u9w3dfPYROVy5YKEtTQ9MHLYnkVKZ4APkWtL4JwUOhW-8q4380wXp0pTeu9ChC4zEGV5oNc2fTgT6rIN9NTXIG4HwCTLCmLLyprQs7jpFUMDlyt1sOBh1rB14H66C2kDsPttN54_555Q-weoPs</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Zambrano-Villa, Sergio</creator><creator>Rosales-Borjas, Disney</creator><creator>Carrero, Julio César</creator><creator>Ortiz-Ortiz, Librado</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>How protozoan parasites evade the immune response</title><author>Zambrano-Villa, Sergio ; Rosales-Borjas, Disney ; Carrero, Julio César ; Ortiz-Ortiz, Librado</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-828a5abbb8079296a9a4172f80d156143002e7546d1f9cac2b761399b56967cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amebiasis - immunology</topic><topic>Animals</topic><topic>Antigenic Variation</topic><topic>Biological and medical sciences</topic><topic>CD4</topic><topic>CD8 I</topic><topic>Chagas Disease - immunology</topic><topic>cytokines</topic><topic>Entamoeba histolytica - immunology</topic><topic>evasion</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>immune response</topic><topic>immunosuppression</topic><topic>Leishmania - immunology</topic><topic>Leishmaniasis - immunology</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>Malaria - immunology</topic><topic>Plasmodium - immunology</topic><topic>Protozoa</topic><topic>Protozoan Infections - immunology</topic><topic>T helper (Th) cells</topic><topic>Trypanosoma - immunology</topic><topic>Trypanosomiasis, African - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zambrano-Villa, Sergio</creatorcontrib><creatorcontrib>Rosales-Borjas, Disney</creatorcontrib><creatorcontrib>Carrero, Julio César</creatorcontrib><creatorcontrib>Ortiz-Ortiz, Librado</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zambrano-Villa, Sergio</au><au>Rosales-Borjas, Disney</au><au>Carrero, Julio César</au><au>Ortiz-Ortiz, Librado</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How protozoan parasites evade the immune response</atitle><jtitle>Trends in Parasitology</jtitle><addtitle>Trends Parasitol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>18</volume><issue>6</issue><spage>272</spage><epage>278</epage><pages>272-278</pages><issn>1471-4922</issn><eissn>1471-5007</eissn><abstract>Protozoan pathogens such as
Plasmodium,
Leishmania,
Trypanosoma and
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The present review describes mechanisms used by some protozoa pathogenic to humans to evade the host immune response. Relatively complex mechanisms by which protozoa penetrate, multiply within the cells and survive are discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12036742</pmid><doi>10.1016/S1471-4922(02)02289-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Trends in Parasitology, 2002-06, Vol.18 (6), p.272-278 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amebiasis - immunology Animals Antigenic Variation Biological and medical sciences CD4 CD8 I Chagas Disease - immunology cytokines Entamoeba histolytica - immunology evasion Fundamental and applied biological sciences. Psychology Humans immune response immunosuppression Leishmania - immunology Leishmaniasis - immunology Life cycle. Host-agent relationship. Pathogenesis Malaria - immunology Plasmodium - immunology Protozoa Protozoan Infections - immunology T helper (Th) cells Trypanosoma - immunology Trypanosomiasis, African - immunology |
| title | How protozoan parasites evade the immune response |
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