Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells

During B-cell development the surrogate light (SL) chain is selectively expressed in progenitor and precursor B cells during the developmental stages of D(H) to J(H) and V(H) to D(H)J(H) rearrangements. Approximately half of all muH chains produced by these rearrangements cannot pair with SL chains...

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Veröffentlicht in:	Immunological reviews 2000-06, Vol.175 (1), p.33-46
Hauptverfasser:	Melchers, F, ten Boekel, E, Seidl, T, Kong, X C, Yamagami, T, Onishi, K, Shimizu, T, Rolink, A G, Andersson, J
Format:	Artikel
Sprache:	eng
Schlagworte:	AB-cell receptor Alleles B-Lymphocytes - immunology Cell Differentiation Cell Lineage Gene Rearrangement, B-Lymphocyte, Heavy Chain Gene Rearrangement, B-Lymphocyte, Light Chain Genes, Immunoglobulin Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - metabolism Immunoglobulin Light Chains, Surrogate Immunoglobulin M - metabolism Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism Ligands Membrane Glycoproteins - metabolism Models, Biological Receptors, Antigen, B-Cell - immunology Receptors, Antigen, B-Cell - metabolism
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