Importance of gas-phase proton affinities in determining the electrospray ionization response for analytes and solvents
The effect of gas‐phase proton transfer reactions on the mass spectral response of solvents and analytes with known gas‐phase proton affinities was evaluated. Methanol, ethanol, propanol and water mixtures were employed to probe the effect of gas‐phase proton transfer reactions on the abundance of p...
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| Veröffentlicht in: | Journal of mass spectrometry. 2000-07, Vol.35 (7), p.784-789 |
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| container_title | Journal of mass spectrometry. |
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| creator | Amad, Ma'an H. Cech, Nadja B. Jackson, George S. Enke, Christie G. |
| description | The effect of gas‐phase proton transfer reactions on the mass spectral response of solvents and analytes with known gas‐phase proton affinities was evaluated. Methanol, ethanol, propanol and water mixtures were employed to probe the effect of gas‐phase proton transfer reactions on the abundance of protonated solvent ions. Ion–molecule reactions were carried out either in an atmospheric pressure electrospray ionization source or in the central quadrupole of a triple‐quadrupole mass spectrometer. The introduction of solvent vapor with higher gas‐phase proton affinity than the solvent being electrosprayed caused protons to transfer to the gas‐phase solvent molecules. In mixed solvents, protonated solvent clusters of the solvent with higher gas‐phase proton affinity dominated the resulting mass spectra. The effect of solvent gas‐phase proton affinity on analyte response was also investigated, and the analyte response was suppressed or eliminated in solvents with gas‐phase proton affinities higher than that of the analyte. Copyright © 2000 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/1096-9888(200007)35:7<784::AID-JMS17>3.0.CO;2-Q |
| format | Article |
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Methanol, ethanol, propanol and water mixtures were employed to probe the effect of gas‐phase proton transfer reactions on the abundance of protonated solvent ions. Ion–molecule reactions were carried out either in an atmospheric pressure electrospray ionization source or in the central quadrupole of a triple‐quadrupole mass spectrometer. The introduction of solvent vapor with higher gas‐phase proton affinity than the solvent being electrosprayed caused protons to transfer to the gas‐phase solvent molecules. In mixed solvents, protonated solvent clusters of the solvent with higher gas‐phase proton affinity dominated the resulting mass spectra. The effect of solvent gas‐phase proton affinity on analyte response was also investigated, and the analyte response was suppressed or eliminated in solvents with gas‐phase proton affinities higher than that of the analyte. 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Mass Spectrom</addtitle><description>The effect of gas‐phase proton transfer reactions on the mass spectral response of solvents and analytes with known gas‐phase proton affinities was evaluated. Methanol, ethanol, propanol and water mixtures were employed to probe the effect of gas‐phase proton transfer reactions on the abundance of protonated solvent ions. Ion–molecule reactions were carried out either in an atmospheric pressure electrospray ionization source or in the central quadrupole of a triple‐quadrupole mass spectrometer. The introduction of solvent vapor with higher gas‐phase proton affinity than the solvent being electrosprayed caused protons to transfer to the gas‐phase solvent molecules. In mixed solvents, protonated solvent clusters of the solvent with higher gas‐phase proton affinity dominated the resulting mass spectra. The effect of solvent gas‐phase proton affinity on analyte response was also investigated, and the analyte response was suppressed or eliminated in solvents with gas‐phase proton affinities higher than that of the analyte. Copyright © 2000 John Wiley & Sons, Ltd.</description><subject>Atmospheric Pressure</subject><subject>electrospray ionization mass spectrometry</subject><subject>gas-phase proton reactions</subject><subject>Gases</subject><subject>ion-molecule reactions</subject><subject>Mass Spectrometry - methods</subject><subject>Protons</subject><subject>Solvents</subject><issn>1076-5174</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv1DAQhSMEou3CX0A-IThkseMkdhaE1C5QFrUsK0BwG3mdcZuStYPtpSy_Hi-pKg5c8GWs0ZtvNO9lmWB0yigtnjHa1HkjpXxS0PTEU17NxAshy9nsePEqf3f-kYmXfEqn8-XzIl_dyQ5vJ-7u_6LOKybKg-wohKsEaJqyvp8dJBEvS14cZteLzeB8VFYjcYZcqJAPlyogGbyLzhJlTGe72GEgnSUtRvSb1LAXJF4iwR519C4MXu1I52z3S8VUiMcwOJsoxnmirOp3MQGUbUlw_Q-0MTzI7hnVB3x4UyfZ5zevP83f5mfL08X8-CzXZSVErqnmaGptjFRNpalUpmaS0XWrBWuQSmN0K0qD6SCxTh4JxVpasqJtVVXhmk-yxyM33fN9iyHCpgsa-15ZdNsAgomKyTQ9yZajUKd7gkcDg-82yu-AUdhnAXtnYe8sjFkAr0BAygIgZQF_sgAOFOZLKGCViI9uVm_XG2z_4o3mJ8FqFFx3Pe7-Y9-_1o2NxMxHZhci_rxlKv8NasFFBV_en8LXk0bSD_wcav4b-RK0Wg</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Amad, Ma'an H.</creator><creator>Cech, Nadja B.</creator><creator>Jackson, George S.</creator><creator>Enke, Christie G.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>Importance of gas-phase proton affinities in determining the electrospray ionization response for analytes and solvents</title><author>Amad, Ma'an H. ; Cech, Nadja B. ; Jackson, George S. ; Enke, Christie G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4577-c0c3ef6cff8a95c08af61810bdc719e08ffcd74fe0937b2007a1d0412dda55eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Atmospheric Pressure</topic><topic>electrospray ionization mass spectrometry</topic><topic>gas-phase proton reactions</topic><topic>Gases</topic><topic>ion-molecule reactions</topic><topic>Mass Spectrometry - methods</topic><topic>Protons</topic><topic>Solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amad, Ma'an H.</creatorcontrib><creatorcontrib>Cech, Nadja B.</creatorcontrib><creatorcontrib>Jackson, George S.</creatorcontrib><creatorcontrib>Enke, Christie G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mass spectrometry.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amad, Ma'an H.</au><au>Cech, Nadja B.</au><au>Jackson, George S.</au><au>Enke, Christie G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Importance of gas-phase proton affinities in determining the electrospray ionization response for analytes and solvents</atitle><jtitle>Journal of mass spectrometry.</jtitle><addtitle>J. Mass Spectrom</addtitle><date>2000-07</date><risdate>2000</risdate><volume>35</volume><issue>7</issue><spage>784</spage><epage>789</epage><pages>784-789</pages><issn>1076-5174</issn><eissn>1096-9888</eissn><abstract>The effect of gas‐phase proton transfer reactions on the mass spectral response of solvents and analytes with known gas‐phase proton affinities was evaluated. Methanol, ethanol, propanol and water mixtures were employed to probe the effect of gas‐phase proton transfer reactions on the abundance of protonated solvent ions. Ion–molecule reactions were carried out either in an atmospheric pressure electrospray ionization source or in the central quadrupole of a triple‐quadrupole mass spectrometer. The introduction of solvent vapor with higher gas‐phase proton affinity than the solvent being electrosprayed caused protons to transfer to the gas‐phase solvent molecules. In mixed solvents, protonated solvent clusters of the solvent with higher gas‐phase proton affinity dominated the resulting mass spectra. The effect of solvent gas‐phase proton affinity on analyte response was also investigated, and the analyte response was suppressed or eliminated in solvents with gas‐phase proton affinities higher than that of the analyte. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10934432</pmid><doi>10.1002/1096-9888(200007)35:7<784::AID-JMS17>3.0.CO;2-Q</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of mass spectrometry., 2000-07, Vol.35 (7), p.784-789 |
| issn | 1076-5174 1096-9888 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Atmospheric Pressure electrospray ionization mass spectrometry gas-phase proton reactions Gases ion-molecule reactions Mass Spectrometry - methods Protons Solvents |
| title | Importance of gas-phase proton affinities in determining the electrospray ionization response for analytes and solvents |
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