Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study

Inhaled corticosteroids are currently the cornerstone of asthma treatment. Some studies of high-dose fluticasone propionate in patients with no or mild asthma have, however, suggested substantial systemic absorption. We investigated the pharmacokinetics of fluticasone propionate in patients with ast...

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Veröffentlicht in:	The Lancet (British edition) 2000-08, Vol.356 (9229), p.556-561
Hauptverfasser:	Brutsche, Martin H, Brutsche, Ingrid Carlen, Munawar, Mohamed, Langley, Stephen J, Masterson, Catherine M, Daley-Yates, Peter T, Brown, Ronan, Custovic, Adnan, Woodcock, Ashley
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Topical Adult Aged Androstadienes - administration & dosage Androstadienes - pharmacokinetics Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - pharmacokinetics Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Area Under Curve Asthma Asthma - drug therapy Asthma - metabolism Asthma - physiopathology Bioavailability Biological and medical sciences Biological Availability Chemiluminescence Chronic obstructive pulmonary disease, asthma Corticoids Cross-Over Studies Double-Blind Method Female Fluticasone Humans Hydrocortisone - metabolism Inhalation Kinetics Male Mass spectrometry Medical research Medical sciences Middle Aged Pharmacokinetics Pharmacology Pneumology Respiratory Mechanics - drug effects Steroids Systematic review
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