A Stable System for the High-Titer Production of Multiply Attenuated Lentiviral Vectors

Lentiviral vectors open exciting perspectives for the genetic treatment of a wide array of inherited and acquired diseases, owing to their ability to govern the efficient delivery, integration, and long-term expression of transgenes into nondividing cells both in vitro and in vivo. The genomic compl...

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular therapy 2000-08, Vol.2 (2), p.170-176
Hauptverfasser:	Klages, Natacha, Zufferey, Romain, Trono, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Blotting, Western Cell Line Cell Separation Cloning Cytomegalovirus Enzymes Experiments Flow Cytometry Gene therapy Genetic Therapy - methods Genetic Vectors Genomes HeLa Cells HIV HIV - genetics HIV-based vectors Human immunodeficiency virus Humans Kinetics lentiviral vectors Lentivirus - genetics Membrane Glycoproteins nondividing cells packaging cell line Pathogenesis Plasmids Plasmids - metabolism Proteins retroviral vectors RNA-Directed DNA Polymerase - metabolism Time Factors transduction Transduction, Genetic Transfection Vectors (Biology) Viral Envelope Proteins - genetics Virulence Viruses VSV G pseudotypes
Online-Zugang:	Volltext
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