Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients
A series of randomized, controlled and masked field studies was conducted in veterinary patients to evaluate the efficacy of selamectin, a novel avermectin, in the treatment of naturally occurring Sarcoptes scabiei infestations on dogs and Otodectes cynotis infestations on dogs and cats. A total of...
Gespeichert in:
| Veröffentlicht in: | Veterinary parasitology 2000-08, Vol.91 (3), p.291-309 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 309 |
|---|---|
| container_issue | 3 |
| container_start_page | 291 |
| container_title | Veterinary parasitology |
| container_volume | 91 |
| creator | Six, R.H Clemence, R.G Thomas, C.A Behan, S Boy, M.G Watson, P Benchaoui, H.A Clements, P.J.M Rowan, T.G Jernigan, A.D |
| description | A series of randomized, controlled and masked field studies was conducted in veterinary patients to evaluate the efficacy of selamectin, a novel avermectin, in the treatment of naturally occurring
Sarcoptes scabiei infestations on dogs and
Otodectes cynotis infestations on dogs and cats. A total of 342 dogs and 237 cats participated in these studies, which were conducted at 40 veterinary practices in the USA and Europe. Animals were randomly assigned to treatment with selamectin or a positive-control product (existing approved products). Selamectin was administered as a unit dose providing a minimum of 6
mg
kg
−1 (range: 6–12
mg
kg
−1) in a topical preparation applied to the skin in a single spot on day 0 (
O. cynotis in cats,
n=144), or on days 0 and 30 (
O. cynotis and
S. scabiei in dogs,
n=83 and
n=122, respectively). The presence of parasites was assessed before treatment and at 30 days (for all studies) and 60 days (for
O. cynotis and
S. scabiei dog studies) after first treatment. The animals were also evaluated clinically at each assessment period. Based on skin scrapings, the efficacy of selamectin against
S. scabiei infestations on dogs was >95% by day 30, and 100% by day 60. Against
O. cynotis, selamectin eliminated mites in 94–100% of cats by day 30, and in 90% of dogs by day 60. The positive-control products achieved similar results. Thus, selamectin was safe and effective against ear mites in dogs and cats and sarcoptic mange in dogs when used in field (veterinary patient) studies in dogs and cats of a wide variety of ages and breeds. |
| doi_str_mv | 10.1016/S0304-4017(00)00300-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71751074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304401700003009</els_id><sourcerecordid>17807987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-c43047c85450790951f03ec152299ff520b35de2a0a7935a5165ed918cf5b71c3</originalsourceid><addsrcrecordid>eNqFkc9uEzEQxi0EoiHwCCCfEBwWxrvrOD6hqip_pEo9FM6WMx5XRsl68TiV8gy8NG5SITj1ZNnzG38z3yfEawUfFKjVxxsYYOxGUOYdwHtoN-jsE7FQazN0vdbwVCz-ImfiBfNPABhhZZ6LMwV2BD3AQvy-jDGhx4P0U5DsI9WDzFEybf2OsKZJ-lufJq7yxhfMcyWWjH6TKMk8yZBv-dh6XXNofKviYco18X9V9JXlXIhpqhSkZ3lHlUqafDnI2dfU3vmleBb9lunVw7kUPz5ffr_42l1df_l2cX7VoVZQOxzbWgbXetRgLFitIgyESve9tTHqHjaDDtR78MYO2mu10hSsWmPUG6NwWIq3p3_nkn_tiavbJUbabv1Eec_OKNOEzPgoqMy6TdAMXwp9ArFk5kLRzSXt2m5OgbuPyx3jcvdZOAB3jMvZ1vfmQWC_2VH4p-uUTwM-nQBqftwlKo6xeYUUUmluu5DTIxJ_ABU9pXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17807987</pqid></control><display><type>article</type><title>Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Six, R.H ; Clemence, R.G ; Thomas, C.A ; Behan, S ; Boy, M.G ; Watson, P ; Benchaoui, H.A ; Clements, P.J.M ; Rowan, T.G ; Jernigan, A.D</creator><creatorcontrib>Six, R.H ; Clemence, R.G ; Thomas, C.A ; Behan, S ; Boy, M.G ; Watson, P ; Benchaoui, H.A ; Clements, P.J.M ; Rowan, T.G ; Jernigan, A.D</creatorcontrib><description>A series of randomized, controlled and masked field studies was conducted in veterinary patients to evaluate the efficacy of selamectin, a novel avermectin, in the treatment of naturally occurring
Sarcoptes scabiei infestations on dogs and
Otodectes cynotis infestations on dogs and cats. A total of 342 dogs and 237 cats participated in these studies, which were conducted at 40 veterinary practices in the USA and Europe. Animals were randomly assigned to treatment with selamectin or a positive-control product (existing approved products). Selamectin was administered as a unit dose providing a minimum of 6
mg
kg
−1 (range: 6–12
mg
kg
−1) in a topical preparation applied to the skin in a single spot on day 0 (
O. cynotis in cats,
n=144), or on days 0 and 30 (
O. cynotis and
S. scabiei in dogs,
n=83 and
n=122, respectively). The presence of parasites was assessed before treatment and at 30 days (for all studies) and 60 days (for
O. cynotis and
S. scabiei dog studies) after first treatment. The animals were also evaluated clinically at each assessment period. Based on skin scrapings, the efficacy of selamectin against
S. scabiei infestations on dogs was >95% by day 30, and 100% by day 60. Against
O. cynotis, selamectin eliminated mites in 94–100% of cats by day 30, and in 90% of dogs by day 60. The positive-control products achieved similar results. Thus, selamectin was safe and effective against ear mites in dogs and cats and sarcoptic mange in dogs when used in field (veterinary patient) studies in dogs and cats of a wide variety of ages and breeds.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/S0304-4017(00)00300-9</identifier><identifier>PMID: 10940530</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Topical ; Animals ; Antiparasitic Agents - administration & dosage ; Antiparasitic Agents - therapeutic use ; Avermectin ; Canis familiaris ; Cat ; Cat Diseases - drug therapy ; Cats ; Dog ; Dog Diseases - drug therapy ; Dogs ; Ear mites ; Felis catus ; Female ; Italy ; Ivermectin - analogs & derivatives ; Ivermectin - therapeutic use ; Male ; Mange ; Mite Infestations - drug therapy ; Mite Infestations - veterinary ; Mites ; Otodectes cynotis ; Revolution ; Sarcoptes scabiei ; Sarcoptic mites ; Sarcoptidae ; Selamectin ; Stronghold ; United States</subject><ispartof>Veterinary parasitology, 2000-08, Vol.91 (3), p.291-309</ispartof><rights>2000 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-c43047c85450790951f03ec152299ff520b35de2a0a7935a5165ed918cf5b71c3</citedby><cites>FETCH-LOGICAL-c510t-c43047c85450790951f03ec152299ff520b35de2a0a7935a5165ed918cf5b71c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304401700003009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10940530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Six, R.H</creatorcontrib><creatorcontrib>Clemence, R.G</creatorcontrib><creatorcontrib>Thomas, C.A</creatorcontrib><creatorcontrib>Behan, S</creatorcontrib><creatorcontrib>Boy, M.G</creatorcontrib><creatorcontrib>Watson, P</creatorcontrib><creatorcontrib>Benchaoui, H.A</creatorcontrib><creatorcontrib>Clements, P.J.M</creatorcontrib><creatorcontrib>Rowan, T.G</creatorcontrib><creatorcontrib>Jernigan, A.D</creatorcontrib><title>Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>A series of randomized, controlled and masked field studies was conducted in veterinary patients to evaluate the efficacy of selamectin, a novel avermectin, in the treatment of naturally occurring
Sarcoptes scabiei infestations on dogs and
Otodectes cynotis infestations on dogs and cats. A total of 342 dogs and 237 cats participated in these studies, which were conducted at 40 veterinary practices in the USA and Europe. Animals were randomly assigned to treatment with selamectin or a positive-control product (existing approved products). Selamectin was administered as a unit dose providing a minimum of 6
mg
kg
−1 (range: 6–12
mg
kg
−1) in a topical preparation applied to the skin in a single spot on day 0 (
O. cynotis in cats,
n=144), or on days 0 and 30 (
O. cynotis and
S. scabiei in dogs,
n=83 and
n=122, respectively). The presence of parasites was assessed before treatment and at 30 days (for all studies) and 60 days (for
O. cynotis and
S. scabiei dog studies) after first treatment. The animals were also evaluated clinically at each assessment period. Based on skin scrapings, the efficacy of selamectin against
S. scabiei infestations on dogs was >95% by day 30, and 100% by day 60. Against
O. cynotis, selamectin eliminated mites in 94–100% of cats by day 30, and in 90% of dogs by day 60. The positive-control products achieved similar results. Thus, selamectin was safe and effective against ear mites in dogs and cats and sarcoptic mange in dogs when used in field (veterinary patient) studies in dogs and cats of a wide variety of ages and breeds.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Antiparasitic Agents - administration & dosage</subject><subject>Antiparasitic Agents - therapeutic use</subject><subject>Avermectin</subject><subject>Canis familiaris</subject><subject>Cat</subject><subject>Cat Diseases - drug therapy</subject><subject>Cats</subject><subject>Dog</subject><subject>Dog Diseases - drug therapy</subject><subject>Dogs</subject><subject>Ear mites</subject><subject>Felis catus</subject><subject>Female</subject><subject>Italy</subject><subject>Ivermectin - analogs & derivatives</subject><subject>Ivermectin - therapeutic use</subject><subject>Male</subject><subject>Mange</subject><subject>Mite Infestations - drug therapy</subject><subject>Mite Infestations - veterinary</subject><subject>Mites</subject><subject>Otodectes cynotis</subject><subject>Revolution</subject><subject>Sarcoptes scabiei</subject><subject>Sarcoptic mites</subject><subject>Sarcoptidae</subject><subject>Selamectin</subject><subject>Stronghold</subject><subject>United States</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQxi0EoiHwCCCfEBwWxrvrOD6hqip_pEo9FM6WMx5XRsl68TiV8gy8NG5SITj1ZNnzG38z3yfEawUfFKjVxxsYYOxGUOYdwHtoN-jsE7FQazN0vdbwVCz-ImfiBfNPABhhZZ6LMwV2BD3AQvy-jDGhx4P0U5DsI9WDzFEybf2OsKZJ-lufJq7yxhfMcyWWjH6TKMk8yZBv-dh6XXNofKviYco18X9V9JXlXIhpqhSkZ3lHlUqafDnI2dfU3vmleBb9lunVw7kUPz5ffr_42l1df_l2cX7VoVZQOxzbWgbXetRgLFitIgyESve9tTHqHjaDDtR78MYO2mu10hSsWmPUG6NwWIq3p3_nkn_tiavbJUbabv1Eec_OKNOEzPgoqMy6TdAMXwp9ArFk5kLRzSXt2m5OgbuPyx3jcvdZOAB3jMvZ1vfmQWC_2VH4p-uUTwM-nQBqftwlKo6xeYUUUmluu5DTIxJ_ABU9pXQ</recordid><startdate>20000823</startdate><enddate>20000823</enddate><creator>Six, R.H</creator><creator>Clemence, R.G</creator><creator>Thomas, C.A</creator><creator>Behan, S</creator><creator>Boy, M.G</creator><creator>Watson, P</creator><creator>Benchaoui, H.A</creator><creator>Clements, P.J.M</creator><creator>Rowan, T.G</creator><creator>Jernigan, A.D</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20000823</creationdate><title>Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients</title><author>Six, R.H ; Clemence, R.G ; Thomas, C.A ; Behan, S ; Boy, M.G ; Watson, P ; Benchaoui, H.A ; Clements, P.J.M ; Rowan, T.G ; Jernigan, A.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-c43047c85450790951f03ec152299ff520b35de2a0a7935a5165ed918cf5b71c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Antiparasitic Agents - administration & dosage</topic><topic>Antiparasitic Agents - therapeutic use</topic><topic>Avermectin</topic><topic>Canis familiaris</topic><topic>Cat</topic><topic>Cat Diseases - drug therapy</topic><topic>Cats</topic><topic>Dog</topic><topic>Dog Diseases - drug therapy</topic><topic>Dogs</topic><topic>Ear mites</topic><topic>Felis catus</topic><topic>Female</topic><topic>Italy</topic><topic>Ivermectin - analogs & derivatives</topic><topic>Ivermectin - therapeutic use</topic><topic>Male</topic><topic>Mange</topic><topic>Mite Infestations - drug therapy</topic><topic>Mite Infestations - veterinary</topic><topic>Mites</topic><topic>Otodectes cynotis</topic><topic>Revolution</topic><topic>Sarcoptes scabiei</topic><topic>Sarcoptic mites</topic><topic>Sarcoptidae</topic><topic>Selamectin</topic><topic>Stronghold</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Six, R.H</creatorcontrib><creatorcontrib>Clemence, R.G</creatorcontrib><creatorcontrib>Thomas, C.A</creatorcontrib><creatorcontrib>Behan, S</creatorcontrib><creatorcontrib>Boy, M.G</creatorcontrib><creatorcontrib>Watson, P</creatorcontrib><creatorcontrib>Benchaoui, H.A</creatorcontrib><creatorcontrib>Clements, P.J.M</creatorcontrib><creatorcontrib>Rowan, T.G</creatorcontrib><creatorcontrib>Jernigan, A.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Six, R.H</au><au>Clemence, R.G</au><au>Thomas, C.A</au><au>Behan, S</au><au>Boy, M.G</au><au>Watson, P</au><au>Benchaoui, H.A</au><au>Clements, P.J.M</au><au>Rowan, T.G</au><au>Jernigan, A.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2000-08-23</date><risdate>2000</risdate><volume>91</volume><issue>3</issue><spage>291</spage><epage>309</epage><pages>291-309</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>A series of randomized, controlled and masked field studies was conducted in veterinary patients to evaluate the efficacy of selamectin, a novel avermectin, in the treatment of naturally occurring
Sarcoptes scabiei infestations on dogs and
Otodectes cynotis infestations on dogs and cats. A total of 342 dogs and 237 cats participated in these studies, which were conducted at 40 veterinary practices in the USA and Europe. Animals were randomly assigned to treatment with selamectin or a positive-control product (existing approved products). Selamectin was administered as a unit dose providing a minimum of 6
mg
kg
−1 (range: 6–12
mg
kg
−1) in a topical preparation applied to the skin in a single spot on day 0 (
O. cynotis in cats,
n=144), or on days 0 and 30 (
O. cynotis and
S. scabiei in dogs,
n=83 and
n=122, respectively). The presence of parasites was assessed before treatment and at 30 days (for all studies) and 60 days (for
O. cynotis and
S. scabiei dog studies) after first treatment. The animals were also evaluated clinically at each assessment period. Based on skin scrapings, the efficacy of selamectin against
S. scabiei infestations on dogs was >95% by day 30, and 100% by day 60. Against
O. cynotis, selamectin eliminated mites in 94–100% of cats by day 30, and in 90% of dogs by day 60. The positive-control products achieved similar results. Thus, selamectin was safe and effective against ear mites in dogs and cats and sarcoptic mange in dogs when used in field (veterinary patient) studies in dogs and cats of a wide variety of ages and breeds.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10940530</pmid><doi>10.1016/S0304-4017(00)00300-9</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 2000-08, Vol.91 (3), p.291-309 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71751074 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Topical Animals Antiparasitic Agents - administration & dosage Antiparasitic Agents - therapeutic use Avermectin Canis familiaris Cat Cat Diseases - drug therapy Cats Dog Dog Diseases - drug therapy Dogs Ear mites Felis catus Female Italy Ivermectin - analogs & derivatives Ivermectin - therapeutic use Male Mange Mite Infestations - drug therapy Mite Infestations - veterinary Mites Otodectes cynotis Revolution Sarcoptes scabiei Sarcoptic mites Sarcoptidae Selamectin Stronghold United States |
| title | Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A20%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20and%20safety%20of%20selamectin%20against%20Sarcoptes%20scabiei%20on%20dogs%20and%20Otodectes%20cynotis%20on%20dogs%20and%20cats%20presented%20as%20veterinary%20patients&rft.jtitle=Veterinary%20parasitology&rft.au=Six,%20R.H&rft.date=2000-08-23&rft.volume=91&rft.issue=3&rft.spage=291&rft.epage=309&rft.pages=291-309&rft.issn=0304-4017&rft.eissn=1873-2550&rft_id=info:doi/10.1016/S0304-4017(00)00300-9&rft_dat=%3Cproquest_cross%3E17807987%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17807987&rft_id=info:pmid/10940530&rft_els_id=S0304401700003009&rfr_iscdi=true |