Neutralization epitopes on the antigenic domain II of the Orientia tsutsugamushi 56-kDa protein revealed by monoclonal antibodies

Monoclonal antibodies (MoAbs) reactive with the authentic Orientia tsutsugamushi 56-kDa protein were generated. MoAb FS10 and FS15 showed in vitro, as well as, in vivo neutralizing activity upon O. tsutsugamushi infection. Deletion mutants of the gene for 56-kDa protein of O. tsutsugamushi Boryong w...

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Veröffentlicht in:	Vaccine 2000-08, Vol.19 (1), p.2-9
Hauptverfasser:	Seong, S.Y., Kim, M.K., Lee, S.M., Odgerel, Z., Choi, M.S., Han, T.H., Kim, I.S., Kang, J.S., Lim, B.U.
Format:	Artikel
Sprache:	eng
Schlagworte:	56-kDa protein Amino Acid Sequence Animals Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Bacteriology Biological and medical sciences Disease Models, Animal Epitope Mapping Epitopes - immunology Fundamental and applied biological sciences. Psychology Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Molecular Weight Neutralization Neutralization Tests Orientia tsutsugamushi Orientia tsutsugamushi - immunology Scrub Typhus - immunology Scrub Typhus - mortality Scrub Typhus - prevention & control Sequence Homology, Amino Acid Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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