Fetal response to maternally administered morphine
Objective: We sought to determine the effects of maternally administered morphine on fetal response. Study Design: Singleton pregnancies requiring fetal blood sampling were enrolled. Only study patients were given morphine intramuscularly. Maternal vital signs, fetal heart rate, biophysical profile...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2000-08, Vol.183 (2), p.424-430 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 183 |
| creator | Kopecky, Ernest A. Ryan, Mary Lou Barrett, Jon F.R. Seaward, P.Gareth R. Ryan, Greg Koren, Gideon Amankwah, Kofi |
| description | Objective: We sought to determine the effects of maternally administered morphine on fetal response. Study Design: Singleton pregnancies requiring fetal blood sampling were enrolled. Only study patients were given morphine intramuscularly. Maternal vital signs, fetal heart rate, biophysical profile score, and umbilical artery Doppler indices (systolic/diastolic ratio, resistance index, and pulsatility index) were completed before and after fetal blood sampling. Maternal and cord blood morphine concentrations were measured. Results: Ten study and 6 control patients were enrolled. A significantly lower biophysical profile score was observed in study patients (P =.001) as a result of absent fetal breathing movements and nonreactive nonstress tests. Gross and fine fetal movements were unaffected. A significant correlation was measured between the biophase morphine concentration and each of the Doppler indices. Conclusion: Morphine administered to the mother causes a significant decrease in the biophysical profile score. Correlation between the biophase morphine concentration and the Doppler indices was calculated. These results suggest that morphine acts as a vasoconstrictor of the placental vasculature but do not support the use of intramuscular morphine to suppress fetal movement. (Am J Obstet Gynecol 2000;183:424-30.) |
| doi_str_mv | 10.1067/mob.2000.105746 |
| format | Article |
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Study Design: Singleton pregnancies requiring fetal blood sampling were enrolled. Only study patients were given morphine intramuscularly. Maternal vital signs, fetal heart rate, biophysical profile score, and umbilical artery Doppler indices (systolic/diastolic ratio, resistance index, and pulsatility index) were completed before and after fetal blood sampling. Maternal and cord blood morphine concentrations were measured. Results: Ten study and 6 control patients were enrolled. A significantly lower biophysical profile score was observed in study patients (P =.001) as a result of absent fetal breathing movements and nonreactive nonstress tests. Gross and fine fetal movements were unaffected. A significant correlation was measured between the biophase morphine concentration and each of the Doppler indices. Conclusion: Morphine administered to the mother causes a significant decrease in the biophysical profile score. Correlation between the biophase morphine concentration and the Doppler indices was calculated. These results suggest that morphine acts as a vasoconstrictor of the placental vasculature but do not support the use of intramuscular morphine to suppress fetal movement. (Am J Obstet Gynecol 2000;183:424-30.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/mob.2000.105746</identifier><identifier>PMID: 10942481</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analgesics, Opioid - blood ; Analgesics, Opioid - therapeutic use ; biophysical profile ; Doppler ; Female ; Fetal Blood ; fetal blood sampling ; Fetal Movement - drug effects ; Fetus ; Fetus - drug effects ; Humans ; Injections, Intramuscular ; Maternal-Fetal Exchange ; morphine ; Morphine - blood ; Morphine - therapeutic use ; Osmolar Concentration ; Pregnancy ; Specimen Handling</subject><ispartof>American journal of obstetrics and gynecology, 2000-08, Vol.183 (2), p.424-430</ispartof><rights>2000 Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-932147d49bad70db9111cd9f7cd1eba8fe9c270c635154e82adaa7adf9b572393</citedby><cites>FETCH-LOGICAL-c343t-932147d49bad70db9111cd9f7cd1eba8fe9c270c635154e82adaa7adf9b572393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mob.2000.105746$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10942481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kopecky, Ernest A.</creatorcontrib><creatorcontrib>Ryan, Mary Lou</creatorcontrib><creatorcontrib>Barrett, Jon F.R.</creatorcontrib><creatorcontrib>Seaward, P.Gareth R.</creatorcontrib><creatorcontrib>Ryan, Greg</creatorcontrib><creatorcontrib>Koren, Gideon</creatorcontrib><creatorcontrib>Amankwah, Kofi</creatorcontrib><title>Fetal response to maternally administered morphine</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: We sought to determine the effects of maternally administered morphine on fetal response. Study Design: Singleton pregnancies requiring fetal blood sampling were enrolled. Only study patients were given morphine intramuscularly. Maternal vital signs, fetal heart rate, biophysical profile score, and umbilical artery Doppler indices (systolic/diastolic ratio, resistance index, and pulsatility index) were completed before and after fetal blood sampling. Maternal and cord blood morphine concentrations were measured. Results: Ten study and 6 control patients were enrolled. A significantly lower biophysical profile score was observed in study patients (P =.001) as a result of absent fetal breathing movements and nonreactive nonstress tests. Gross and fine fetal movements were unaffected. A significant correlation was measured between the biophase morphine concentration and each of the Doppler indices. Conclusion: Morphine administered to the mother causes a significant decrease in the biophysical profile score. Correlation between the biophase morphine concentration and the Doppler indices was calculated. These results suggest that morphine acts as a vasoconstrictor of the placental vasculature but do not support the use of intramuscular morphine to suppress fetal movement. (Am J Obstet Gynecol 2000;183:424-30.)</description><subject>Analgesics, Opioid - blood</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>biophysical profile</subject><subject>Doppler</subject><subject>Female</subject><subject>Fetal Blood</subject><subject>fetal blood sampling</subject><subject>Fetal Movement - drug effects</subject><subject>Fetus</subject><subject>Fetus - drug effects</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Maternal-Fetal Exchange</subject><subject>morphine</subject><subject>Morphine - blood</subject><subject>Morphine - therapeutic use</subject><subject>Osmolar Concentration</subject><subject>Pregnancy</subject><subject>Specimen Handling</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDFPwzAQRi0EoqUws6FMbGltx4njEVUUkCqxwGw59kUYxXGwU6T-exylQxem06d7_k5-CN0TvCa44hvnmzXFeEolZ9UFWhIseF7VVX2JlmlBc1HweoFuYvyeIhX0Gi0SxCiryRLRHYyqywLEwfcRstFnTo0QetV1x0wZZ3sbUwaTOR-GL9vDLbpqVRfh7jRX6HP3_LF9zffvL2_bp32uC1aM6S4ljBsmGmU4No0ghGgjWq4NgUbVLQhNOdZVUZKSQU2VUYor04qm5LQQxQo9zr1D8D8HiKN0NmroOtWDP0TJCWcinUjgZgZ18DEGaOUQrFPhKAmWkyaZNMlJk5w1pRcPp-pD48Cc8bOXBIgZgPTBXwtBRm2h12BsAD1K4-2_5X-uNnaB</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Kopecky, Ernest A.</creator><creator>Ryan, Mary Lou</creator><creator>Barrett, Jon F.R.</creator><creator>Seaward, P.Gareth R.</creator><creator>Ryan, Greg</creator><creator>Koren, Gideon</creator><creator>Amankwah, Kofi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>Fetal response to maternally administered morphine</title><author>Kopecky, Ernest A. ; Ryan, Mary Lou ; Barrett, Jon F.R. ; Seaward, P.Gareth R. ; Ryan, Greg ; Koren, Gideon ; Amankwah, Kofi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-932147d49bad70db9111cd9f7cd1eba8fe9c270c635154e82adaa7adf9b572393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analgesics, Opioid - blood</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>biophysical profile</topic><topic>Doppler</topic><topic>Female</topic><topic>Fetal Blood</topic><topic>fetal blood sampling</topic><topic>Fetal Movement - drug effects</topic><topic>Fetus</topic><topic>Fetus - drug effects</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Maternal-Fetal Exchange</topic><topic>morphine</topic><topic>Morphine - blood</topic><topic>Morphine - therapeutic use</topic><topic>Osmolar Concentration</topic><topic>Pregnancy</topic><topic>Specimen Handling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kopecky, Ernest A.</creatorcontrib><creatorcontrib>Ryan, Mary Lou</creatorcontrib><creatorcontrib>Barrett, Jon F.R.</creatorcontrib><creatorcontrib>Seaward, P.Gareth R.</creatorcontrib><creatorcontrib>Ryan, Greg</creatorcontrib><creatorcontrib>Koren, Gideon</creatorcontrib><creatorcontrib>Amankwah, Kofi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kopecky, Ernest A.</au><au>Ryan, Mary Lou</au><au>Barrett, Jon F.R.</au><au>Seaward, P.Gareth R.</au><au>Ryan, Greg</au><au>Koren, Gideon</au><au>Amankwah, Kofi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal response to maternally administered morphine</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>183</volume><issue>2</issue><spage>424</spage><epage>430</epage><pages>424-430</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Objective: We sought to determine the effects of maternally administered morphine on fetal response. Study Design: Singleton pregnancies requiring fetal blood sampling were enrolled. Only study patients were given morphine intramuscularly. Maternal vital signs, fetal heart rate, biophysical profile score, and umbilical artery Doppler indices (systolic/diastolic ratio, resistance index, and pulsatility index) were completed before and after fetal blood sampling. Maternal and cord blood morphine concentrations were measured. Results: Ten study and 6 control patients were enrolled. A significantly lower biophysical profile score was observed in study patients (P =.001) as a result of absent fetal breathing movements and nonreactive nonstress tests. Gross and fine fetal movements were unaffected. A significant correlation was measured between the biophase morphine concentration and each of the Doppler indices. Conclusion: Morphine administered to the mother causes a significant decrease in the biophysical profile score. Correlation between the biophase morphine concentration and the Doppler indices was calculated. These results suggest that morphine acts as a vasoconstrictor of the placental vasculature but do not support the use of intramuscular morphine to suppress fetal movement. (Am J Obstet Gynecol 2000;183:424-30.)</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10942481</pmid><doi>10.1067/mob.2000.105746</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analgesics, Opioid - blood Analgesics, Opioid - therapeutic use biophysical profile Doppler Female Fetal Blood fetal blood sampling Fetal Movement - drug effects Fetus Fetus - drug effects Humans Injections, Intramuscular Maternal-Fetal Exchange morphine Morphine - blood Morphine - therapeutic use Osmolar Concentration Pregnancy Specimen Handling |
| title | Fetal response to maternally administered morphine |
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