Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage– colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses

Cell vaccines engineered to express immunomodulators have shown feasibility in eliminating leukemia in murine models. Vectors for efficient gene delivery to primary human leukemia cells are required to translate this approach to clinical trials. In this study, second-generation lentiviral vectors de...

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Veröffentlicht in:	Blood 2000-08, Vol.96 (4), p.1317-1326
Hauptverfasser:	Stripecke, Renata, Cardoso, Angelo A., Pepper, Karen A., Skelton, Dianne C., Yu, Xiao-Jin, Mascarenhas, Leo, Weinberg, Kenneth I., Nadler, Lee M., Kohn, Donald B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease AIDS/HIV Antineoplastic agents B7-1 Antigen - genetics B7-1 Antigen - immunology B7-1 Antigen - therapeutic use Biological and medical sciences Biotechnology Cytotoxicity, Immunologic - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Health. Pharmaceutical industry Humans Immunotherapy Industrial applications and implications. Economical aspects Lentivirus Leukemia, Myeloid - genetics Leukemia, Myeloid - immunology Leukemia, Myeloid - therapy Medical sciences Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Tumor Cells, Cultured
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