Comparison of manual versus ambulatory blood pressure measurements with pharmacokinetic‐pharmacodynamic modeling of antihypertensive compounds: Application to moxonidine

Objectives To compare the results of the pharmacokinetic‐pharmacodynamic analyses of 24‐hour ambulatory blood pressure measurements and manual blood pressure data in patients receiving moxonidine. Methods 32 patients with borderline to mild‐to‐moderate hypertension were enrolled in a double‐blind, p...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2000-07, Vol.68 (1), p.18-27
Hauptverfasser:	Trocóniz, Iñaki F., Alwis, Dinesh P., Tillmann, Christiane, Callies, Sophie, Mitchell, Malcolm, Schaefer, Hans G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antihypertensive agents Antihypertensive Agents - pharmacology Biological and medical sciences Blood Pressure - drug effects Blood Pressure Determination - instrumentation Blood Pressure Determination - methods Blood Pressure Monitoring, Ambulatory Cardiovascular system Double-Blind Method Drug Administration Schedule Female Humans Hypertension - drug therapy Imidazoles - administration & dosage Imidazoles - pharmacokinetics Imidazoles - pharmacology Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Models, Statistical Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pharmacology. Drug treatments Severity of Illness Index Time Factors
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