Amplification of Transgene Expression in Vitro and in Vivo Using a Novel Inhibitor of Histone Deacetylase

Enhancement of transgene expression is an important issue in human gene therapy. Here we describe a novel system for enhancing transgene expression by cointroduction of plasmid DNA with FR901228, a water-soluble histone deacetylase inhibitor. When a luciferase expression vector was cointroduced into...

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Veröffentlicht in:	Molecular therapy 2000-06, Vol.1 (6), p.574-580
Hauptverfasser:	Yamano, Tomoki, Ura, Kiyoe, Morishita, Ryuichi, Nakajima, Hidenori, Monden, Morito, Kaneda, Yasufumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Cell culture Cell cycle Cellulose acetate Cytomegalovirus Depsipeptides Drug dosages Enzyme Inhibitors - pharmacology Fibroblasts Gene expression Gene Expression - drug effects Gene therapy Genes, Reporter Genetic Therapy - methods histone deacetylase inhibitor Histone Deacetylase Inhibitors Humans Laboratories Lipids Luciferases - genetics Male Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Peptides, Cyclic Pore size Sucrose transcription Transcription factors Transfection Tumor Cells, Cultured
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