Purification and preliminary characterization of a plasma kallikrein inhibitor isolated from sea hares Aplysia dactylomela Rang, 1828

An inhibitor active against pancreatic trypsin was found in the crude extract from the sea hares Aplysia dactylomelaRang, 1828. A stronger inhibitory activity against human plasma kallikrein was detectable after treating this extract at 60 °C, for 30 min. The plasma kallikrein inhibitor (AdKI) purif...

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Veröffentlicht in:	Toxicon (Oxford) 2004-02, Vol.43 (2), p.219-223
Hauptverfasser:	González, Y, Araujo, M.S, Oliva, M.L.V, Sampaio, C.A.M, Chávez, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Aplysia - chemistry Aplysia dactylomela Biological and medical sciences Blood Coagulation - drug effects Chemical Fractionation Chromatography, Gel Humans kallikrein Medical sciences Mollusca Plasma Kallikrein - antagonists & inhibitors Proteinase inhibitor Serine proteinase Time Factors Toxicology
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