Beta‐glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation

Metastases from renal cell carcinomas (RCC) are resistant to radiation and chemotherapy but are relatively immunogenic. We have investigated the possibility to eliminate human RCC micrometastases using MAb G250. G250 penetrates human micrometastases completely in a spheroid model and induces complem...

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Veröffentlicht in:	International journal of cancer 2004-05, Vol.109 (6), p.900-908
Hauptverfasser:	Sier, Cornelis F.M., Gelderman, Kyra A., Prins, Frans A., Gorter, Arko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antibody-Dependent Cell Cytotoxicity - immunology Antineoplastic agents Apoptosis Biological and medical sciences Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - secondary Carcinoma, Renal Cell - therapy CD3 Complex - immunology complement activation Complement Activation - immunology Complement System Proteins - physiology Cytotoxicity, Immunologic Enzyme-Linked Immunosorbent Assay Flow Cytometry Glucans - pharmacology Humans Immunotherapy Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kidney Neoplasms - therapy Medical sciences Microscopy, Fluorescence Pharmacology. Drug treatments renal cell carcinoma Spheroids, Cellular - immunology Spheroids, Cellular - metabolism Tumor Cells, Cultured β‐glucan
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