Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell‐mediated expansion

Brain tumors carry a poor prognosis, and newer approaches to their therapy are urgently needed. Natural killer T (NKT) cells are distinct innate lymphocytes with antitumor potentials. Defects in NKT cell function have been observed in patients with other forms of cancer. Here we show that both the f...

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Veröffentlicht in:	International journal of cancer 2004-05, Vol.109 (6), p.893-899
Hauptverfasser:	Dhodapkar, Kavita M., Cirignano, Barbara, Chamian, Francesca, Zagzag, David, Miller, Douglas C., Finlay, Jonathan L., Steinman, Ralph M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD1 - metabolism Antigens, CD1d Antineoplastic agents Biological and medical sciences Brain Neoplasms - immunology Brain Neoplasms - pathology CD1d Cytotoxicity, Immunologic Dendritic Cells - immunology Endothelium, Vascular - metabolism Enzyme-Linked Immunosorbent Assay Female Galactosylceramides - immunology Galactosylceramides - metabolism glioma Glioma - immunology Glioma - pathology Humans Immunotherapy innate immunity Interferon-gamma - biosynthesis interferon‐γ Killer Cells, Natural - immunology Ligands Male Medical sciences Middle Aged Pharmacology. Drug treatments T-Lymphocytes - immunology
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